摘要：These experiments identified the sialomucin CD34 as being exclusively expressed by LECs in human tumors but not in corresponding normal tissues。 CD34 is expressed by LYVE-1+/podoplanin+/Prox1+ tum...

摘要：Ex Vivo Study of Aneurysmal ThrombusMural thrombi collected during surgery were rapidly dissected into three layers: luminal, intermediate, and abluminal, as previously reported。 Thrombus areas we...

摘要：9-11Stem cells are self-renewable, pluripotent cells that in adult life proliferate by a characteristic asymmetric division in which one daughter cell is committed to differentiation whereas the ot...

摘要：Protein Microarray AnalysisExtraction, labeling, and analysis were based on the method supplied by BD Biosciences (Clontech)。 Expression of proteins considered to be deregulated and relevant to th...

摘要：Laminins are a family of -ß。6 Laminin 2 chain represents the 2 chain of laminin-21 。 Laminin 2 Chain-Positive Vessels in Atypical Carcinoid of the LungTable 2。 Laminin 2 Chain-Positive Vess...

摘要：【摘要】 The mouse mammary tumor virus (MMTV) provirus was found to target the Notch1 gene, producing insertional mutations in mammary tumors of MMTV/neu transgenic (Tg) mice。 In these mammar...

摘要：however, in the siRNA clones, large tumors failed to develop, and incidence of metastasis was significantly reduced, suggesting that c-Src activity is critical to tumor progression。 To examine thi...

摘要：【摘要】 Heat shock proteins (Hsps) facilitate refolding of denatured polypeptides, but there is limited understanding about their roles in neurodegenerative diseases characterized by misfolde...

摘要：【摘要】 Variant Creutzfeldt-Jakob disease (vCJD) differs from other human prion diseases in that the pathogenic prion protein PrPSc can be detected to a greater extent at extraneuronal sites ...

摘要：The cGFAP-CCP Ab as a Marker for Caspase-Mediated Cleavage of GFAP in the AD BrainAfter confirmation of the cGFAP-CCP Ab as a specific probe for the C-terminal caspase-cleavage fragment of GFAP, im...

摘要：Cardiovasc Drug Rev 1997, 15:157-173Altavilla D, Squadrito G, Minutoli L, Deodato B, Bova A, Sardella A, Seminara P, Passaniti M, Urna G, Venuti SF, Caputi AP, Squadrito F: Inhibition of nuclear fa...

摘要：34 Mice were engineered to lack most of exon 6 of the gene, including the part encoding the transmembrane domain at the C-terminal end of emerin。 【关键词】 emerin-lacking dysfunctions n...

摘要：14,15 Mice such as SAMP1, A/J, SJL/J, SM/J, and the congenic R1。 Mice were raised under specific pathogen-free conditions at 24 。19Evaluation of Maternal and Paternal TransmissionIn the first exp...

摘要：--------------------------------------------------------------------------------Glial fibrillary acidic protein (GFAP) is a member of the type III intermediate filament (IF) protein family and has ...

摘要：7-13 Markers of the G1/S transition, such as cyclin E and Cdc25A, were also found to be abnormally expressed in degenerating nerve cells。ResultsAnalysis of Cell-Cycle Protein ExpressionThe express...

摘要：【摘要】 Type IV collagen, a major component of the basement membrane (BM), is composed of six genetically distinct (IV) chains, 1(IV) to 6(IV)。 Their genes are paired on three different chro...

摘要：Discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase whose ligand is collagen, is expressed in vivo and contributes in vitro to leukocyte differentiation and nuclear factor (NF)-B activat...

摘要：Few CD4+ and CD8+ T cells expressed an activated phenotype (CD44hi, CD25+, CD69+, CD62Llo, CD45RBlo) at the sites of clonal expansion (lymph nodes, spleen, and blood)。 Additionally, the polarizati...

摘要：【摘要】 Perivascular macrophages are uniquely situated at the intersection between the nervous and immune systems。 Although combined myeloid marker detection differentiates perivascular from...

摘要：【摘要】 Basic fibroblast growth factor (bFGF, FGF-2) is a potent angiogenic factor and endothelial cell mitogen。 Basic fibroblast growth factor (bFGF, FGF-2) has been associated with tumor a...

摘要：Therefore, we examined the role of CD19, a B cell-specific surface molecule that defines signaling thresholds critical for B-cell responses and autoimmunity, on the development of EAE。 Following i...

摘要：【摘要】 Buruli ulcer is an emerging chronic painless skin disease found in the tropics and caused by Mycobacterium ulcerans。 Nerve invasion occurred in the perineurium and extended to the en...

摘要：Oligodendroglia were identified with anti-adenomatus ployposis coli mAb (Ab-7 Oncogene Research Products, Cambridge, MA) and visualized with peroxidase a NovaRED substrate kit (Vector Laboratories,...

摘要：In Vivo Depletion of CD4+ and CD8+ T Cells, NK Cells, and MacrophagesTo deplete CD4+ and CD8+ T cells, mice were injected intravenously with rat anti-mouse CD4 (YTS191。 Cells were overlaid on 24% ...

摘要：and the extent of apoptosis in gelsolin knockout (gsnC/C) versus wild-type mice (gsn+/+) after exposure to stimulatory Fas antibody Jo-2。 Gelsolin was expressed exclusively in sinusoidal lining ce...

摘要：13 Severely impaired wound-healing conditions in ob/ob mice were strongly improved by administration of leptin, where leptin mediated wound re-epithelialization in a direct manner but attenuated ch...

摘要：--------------------------------------------------------------------------------Tumor necrosis factor (TNF-) is a pleiotropic cytokine that plays an important role in immunity and inflammation。 A...

摘要：Human recombinant PRL was purchased from R&D Systems (Minneapolis, MN)。 Human pituitary gland sections were used as positive controls。 Human mammary gland sections served as positive control。Iso...

摘要：【摘要】 Connective tissue growth factor (CTGF), a downstream mediator of transforming growth factor-ß。--------------------------------------------------------------------------------Con...

摘要：Cardiac dysfunction was associated with selective increases in nonfocal infiltration of CD68+ cells and correlated with the extent of cardiac dysfunction。33Cardiac performance was assessed by echo...

摘要：【摘要】 Semicarbazide-sensitive amine oxidase (SSAO) resides on the vascular endothelium and smooth muscle cell surface and is capable of deaminating short chain aliphatic amines and producin...