摘要：Pulmonary endothelium forms a semiselective barrier for macromolecules and cell elements regulated by contractile and tethering forces generated by interaction of cytoskeletal elements and cell adh...

摘要：Western Blotting Analysis of the Activation State of MAPK and the Levels of HO-1HUVECs were cultured in serum-containing medium until 50 to 70% confluency and then made quiescent by incubating with...

摘要：【摘要】 We previously documented protein kinase CK2 involvement in retinal neovascularization。 Here we describe retinal CK2 expression and combined effects of CK2 inhibitors with the somatos...

摘要：25 Murine BM cells were obtained as described26 from flk1/lacZ-positive mice and transgene-negative littermates as controls。 Murine MNCs were isolated by density centrifugation over Lympholyte-M (...

摘要：Growth of the cell lines is stimulated by EGF in vitro and blocked by antagonists of the EGFR。Analysis of EGFR+p75+ Cells from Perinatal NervesWe dissected sciatic nerves from individual mouse P0 ...

摘要：Doxycycline is a broad spectrum matrix metalloproteinase inhibitor that is under investigation for the treatment of acute coronary syndromes and aneurysms。 Doxycycline treatment dramatically incre...

摘要：Gene Expression ProfilingWe used methodologies recommended by the Expression Analysis Technical Manual published by Affymetrix (Santa Clara, CA)。Quantitative Analysis of OPN Expression by Real-Tim...

摘要：Salivary Glands Phenotype of K5-tet-on/tet-o-K-rasMiceSalivary Gland PhenotypeSubmaxillary glands were affected in all cases, displaying the wider range of pathological alterations。 【参考...

摘要：Apoptosis AssayA mechanically dissociated cutaneous melanoma metastasis preserved in liquid nitrogen was thawed in serum-free lymphocyte medium (AIMV。ResultsExpression of gal-3 and gal-1 in Human ...

摘要：【摘要】 Myxoid/round cell liposarcoma (MLS/RCLS) is the most common subtype of liposarcoma。 Most MLS/RCLS carry a t(12。 We investigated the role of the FUS-DDIT3 fusion in the development o...

摘要：Here we describe constitutive expression of the protein tyrosine kinase Brk in a large proportion of cutaneous T-cell lymphomas and other transformed T- and B-cell populations。 Brk expression was ...

摘要：【摘要】 Gangliosides participate in various cellular events of the central nervous system and have been closely implicated in many neuronal diseases。 Gangliosides rapidly altered the cell su...

摘要：8,9Manganese superoxide dismutase (MnSOD) is a homotetramer consisting of identical 24-kd subunits。Increased Nitration of MnSOD in APP/PS-1 MiceMnSOD is susceptible to peroxynitrite-induced inacti...

摘要：ResultsrTg4510 Brain Suffers Dramatic Neuron Loss with Regional VulnerabilityIn a previous study, marked atrophy of the rTg4510 brain was noted along with neuronal loss in the hippocampal CA1 regio...

摘要：【摘要】 The six chains of type IV collagen are organized into three networks: 1/2, 3/4/5, and 1/2/5/6。 In conclusion, testis can serve as a model system to study the sequence of type IV col...

摘要：【摘要】 Uncoupling protein 2 (UCP2) is a member of the mitochondrial transporter superfamily that is expressed in many tissues, including immune cells。 Brain 2001, 124:1927-1938Fleury C, Nev...

摘要：【摘要】 Metastasis from the primary tumor to distant sites involves an array of molecules that function in an integrated manner。--------------------------------------------------------------...

摘要：8-10 Macrophage-tropic SIV is the predominant virus found in the CNS of macaques with SIVE。 Longitudinal peripheral blood counts for CD4+ lymphocytes (a), CD8+ lymphocytes (b), and monocytes (c) o...

摘要：p21C/C Mice Have a Significant Decrease in Inflammatory Monocytes in Circulation and in Monocyte Precursors in Bone MarrowBecause there is a severe reduction in the number of macrophages in p21C/C ...

摘要：Coxsackievirus B3 (CVB3) infections are one of the most frequent causes of human myocarditis。 【参考文献】 Mason JW: Myocarditis and dilated cardiomyopathy: an inflammatory link。 Med Mic...

摘要：Cytoplasmic lysates for both NCH and LCH (100 µ。Cytoplasmic sequestration of Map53 protein is a characteristic feature of the phenotype of LCH,10 and Map53 and Mamot are often concentrated ne...

摘要：Am J Pathol 1994, 145:375-383Michalopoulos GK, Bowen WC, Mule K, Lopez-Talavera JC, Mars W: Hepatocytes undergo phenotypic transformation to biliary epithelium in organoid cultures。 Science 1997, ...

摘要：Matriptase was also expressed in keratinizing oral epithelium, where it was required for oral barrier function, and in thymic epithelium。16Matriptase was identified in part through its consistent ...

摘要：29 Cadherin-mediated cell-to-cell contacts, however, are not static。Plasmids and Generation of L-Cell-Cadherin-11 Stable TransfectantsThe human cadherin-11 cDNA or E-cadherin cDNA was inserted int...

摘要：Liver Transpl 2002, 8:415-423Yamagami K, Yamamoto Y, Kume M, Kimoto S, Yamamoto H, Ozaki N, Yamamoto M, Shimahara Y, Toyokuni S, Yamaoka Y: Heat shock preconditioning ameliorates liver injury follo...

摘要：【摘要】 Hypoxic stress activates various signal transduction pathways including posttranslational modification with the ubiquitin-like SUMO protein (SUMOylation)。 However, the molecular mech...

摘要：【摘要】 Interferon- (IFN) is a pleiotropic cytokine that plays an important role in many inflammatory processes, including autoimmune diseases such as multiple sclerosis (MS)。 Accordingly, i...

摘要：Mitochondrial superoxide and hydrogen peroxide levels were also markedly decreased in the DZ-treated injury group compared with the untreated group。 These studies indicate for the first time that ...

摘要：【摘要】 Fatty acid ethyl esters (FAEEs), nonoxidative metabolites of ethanol, have been implicated in ethanol-induced heart injury。 To assess the in vivo production of FAEEs by myocardial ti...

摘要：Lipopolysaccharide from Salmonella abortus equi S-form was purchased from Alexis Corp。Airway Inflammation Is Sensitive to the Dose of Intranasal Antigen ChallengeBecause our initial experiments sh...

摘要：【关键词】 attenuation acid-induced inflammatory platelet-activating receptor-deficient Materials and MethodsReagentsFolic acid was obtained from Sigma Chemical Co。ResultsAttenuation of Renal D...