摘要:Thus, inhibition of NADPH oxidase-derived ROS overproduction improves the angiogenic and vasculogenic processes and restores postischemic neovascularization in type 1 diabetic mice。Reactive oxygen...
08-05-29摘要:Genes Dev 2005, 19:397-410Saaristo A, Veikkola T, Tammela T, Enholm B, Karkkainen MJ, Pajusola K, Bueler H, Yla-Herttuala S, Alitalo K: Lymphangiogenic gene therapy with minimal blood vascular side...
08-05-29摘要:【摘要】 P-Selectin expressed on endothelial cells contributes to acute and chronic inflammation by promoting leukocyte tethering/rolling。 Despite increasing evidence of P-selectin expression...
08-05-29摘要:23,24 Androgen-dependent CWR22 xenografts responded initially to castration and then relapsed with androgen-independent tumors that were resistant to high-dose bicalutamide treatment and maintained...
08-05-29摘要:Nature 2001, 413:86-91Sotillo R, Garcia JF, Ortega S, Martin J, Dubus P, Barbacid M, Malumbres M: Invasive melanoma in Cdk4-targeted mice。 Nat Med 2002, 8:1276-1280Comoglio PM, Trusolino L: Invasi...
08-05-29摘要:Cells recovered from bone marrows and spleens, where there were no metastases, were as tumorigenic and metastatic as cells recovered from lungs and lymph nodes, which are the preferred sites of col...
08-05-29摘要:We show here that ID2, which can inactivate E2A and perhaps PAX5, is not detectable in normal B cells but is strongly and uniformly expressed in HRS cells of all cases of classical HL。 Recurrent c...
08-05-29摘要:【关键词】 increased melanoma metastasis spreading overexpressing placenta Materials and MethodsCell Culture and Growth FactorsB16-BL6 murine melanoma cell line was maintained in Dulbecco。 Huma...
08-05-29摘要:【摘要】 Signal transducers and activators of transcription (STAT)-3 is an oncogenic protein that is constitutively activated in many human cancers, including 30 to 60% of primary breast cance...
08-05-29摘要:6-8Relaxin and the relaxin-like INSL3 have been shown to activate cAMP-dependent signaling pathways by binding to either LGR7 or LGR8。14-17 Relaxin affects proliferation and differentiation of MCF...
08-05-29摘要:【摘要】 Tau transgenic mice are valuable models to investigate the role of tau protein in Alzheimer。s disease and other tauopathies。 However, motor dysfunction and dystonic posture interfer...
08-05-29摘要:Ciliary neurotrophic factor (CNTF) is a four -helix bundle cytokine initially identified as a survival factor for chick ciliary neurons。 Administration of high doses of CNTF was associated with re...
08-05-29摘要:Cerebral capillary permeability was tested by intraperitoneal injection of 2% Evans blue (Sigma, St。Arterial Blood GasesCerebral hemispheric ischemia/hypoxia was performed as described above。Prog...
08-05-29摘要:【摘要】 NUB1 is a potent down-regulator of the ubiquitin-like protein NEDD8, because it targets NEDD8 to the proteasome for proteolytic degradation。 From results in this study, we found that...
08-05-29摘要:Four months of continuous and diversified environmental stimulation resulted in a significant reduction of ß。-amyloid (Aß。 Neither human amyloid precursor protein (APP) mRNA/protein lev...
08-05-29摘要:6-8Spiral ganglion neurons (SGNs) express the neurotrophin receptors tropomyosin-related kinase (Trk) receptor tyrosine kinase and the p75 neurotrophin receptor (NTR), a member of the tumor necrosi...
08-05-29摘要:Matrilin-1 (also known as cartilage matrix protein) and matrilin-3 are abundant in cartilage,2-4 whereas matrilin-2 and matrilin-4 show a broader tissue distribution。12Matrilin-3 is the least comp...
08-05-29摘要:Deletion of the UBA Domain of p62 Potentiates RANKL-Mediated Osteoclast Formation and MultinucleationThe observed morphological increase in osteoclast size suggested that the UBA domain may play a ...
08-05-29摘要:【摘要】 Osteoarthritic (OA) chondrocytes are metabolically active, displaying increased synthesis of type II collagen。 Here, we show by immunohistochemistry and polymerase chain reaction tha...
08-05-29摘要:Elevated CYR61 caused down-regulation of transforming growth factor-ß。4-6 Aberrant expression of CCN genes is associated with several pathological states including fibrotic diseases and tumor...
08-05-29摘要:Muscle cells in these organs are responsive to stretch in their microenvironment。 Mechanotransduction in the heart and vessels involves growth factor release and activation of a number of signalin...
08-05-29摘要:ResultsComparison of JAK2 Mutation Status and Expression of Genes Involved in the Turnover of FibersThe overall frequency of V617F JAK2 mutations in the study group was 45% (9% homozygosity, 36% he...
08-05-29摘要:Isolation of Human NK CellsThe following studies using human donors were performed in accordance with the Osaka Dental University (Osaka, Japan) (protocol no。 Human CXCL12 (100 ng/ml) was diluted ...
08-05-29摘要:Sepsis is defined as a host systemic inflammatory response to infection and is complicated in severe sepsis with organ dysfunction, hypoperfusion, and coagulation abnormalities。PA ELISAAnthrax PA ...
08-05-29摘要:【摘要】 Connexins (Cxs) are transmembranous proteins that connect adjacent cells via channels known as gap junctions。Mutation AnalysisGenomic DNA was extracted from peripheral blood and used...
08-05-29摘要:【摘要】 CXCR4 is a major receptor for CXCL12 and is known to participate in multiple physiological systems。 The present study tested a second generation CXCR4 antagonist, AMD3465, for effect...
08-05-29摘要:Transforming growth factor (TGF)-ß。 Science 2004, 303:848-851Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G: Transforming growth factor-ß。
08-05-29摘要:Release was associated with increased apoptosis, confirmed by increased activation of caspase-3 on Western blotting, and immunolocalized to the syncytiotrophoblast。 Oxidative stress is a powerful ...
08-05-29摘要:Macrophage-Derived NO Is an Important Mediator of MDCK Cell Apoptosis but Is Not Implicated in the Inhibition of MDCK Cell ProliferationPrevious data indicate that macrophage-derived NO is involved...
08-05-29摘要:Chemokines, a major class of leukocyte chemoattractants, are particularly relevant in this regard and have been implicated in the pathogenesis of numerous fibrotic disorders。 CCR1 and CXCR2 peaked...
08-05-29摘要:Primers and Antibodies Used in This StudyGene Chip Microarray Assay and Real-Time PCR StudyHASMC was cultured until a subconfluent state was obtained。 When analyzing possible functions of these de...
08-05-29摘要:We examined the effects of continuous and intermittent 17ß。 Continuous E2 replacement (CE2) throughout 9 months prevented microalbuminuria and excess extracellular matrix accumulation in Ovx ...
08-05-29摘要:【摘要】 The recent prospective isolation of a wide variety of somatically derived stem cells has affirmed the notion that homeostatic maintenance of most tissues and organs is mediated by tis...
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