摘要：Caspases are a family of cysteinyl proteases。 Cell Types with Active Caspases in Physiological Functions Other Than ApoptosisThe Initiator and Effector Paradigm of Proteolytic Activation of Caspas...

摘要：Vascular endothelial growth factors (VEGFs) are considered powerful therapeutic tools for proangiogenic and prolymphangiogenic therapy in many settings。 【关键词】 vascular endothelial f...

摘要：D: Human normal serum diluted in blocking buffer was supplemented with increasing concentrations of hGBP-1-His (black circles), hGBP-3-His (squares), His-eGFP (triangles), and BSA (white circles) a...

摘要：Phosphorylation of serines 608/612 inhibits binding of E2F-1 to RB。6,7 Phosphorylation of RB is associated with functional inactivation8 and initiation of the E2F transcriptional program to enter ...

摘要：Cell extravasation of highly metastatic HT-29LMM and KM-12L4 cells into liver parenchyma was significantly higher compared to low metastatic cells (P 0。 Cell adhesion of circulating tumor cells o...

摘要：【摘要】 Experiments with amyloid-ß。 (Aß。 Neuropathological examination of patients vaccinated against purified Aß。 Our experiments suggest that although immunization disrupt...

摘要：3-5Complement activation, by any one of three pathways (classical, alternative, or lectin), converges at the cleavage of C3 by C3 convertases and then proceeds in a common pathway to form the termi...

摘要：Are the Vacuolated Cells Infected。 Oligodendrocytes expressing high levels of viral protein exhibited focal cytoplasmic vacuolation, whereas those cells with the most extreme cytopathic effects ap...

摘要：【摘要】 Combination therapy with multiple sclerosis (MS) therapeutics is gaining momentum over monotherapy for improving MS。 Lovastatin, an HMG-CoA reductase inhibitor (statin), was immunomo...

摘要：Microtubules consist of - and ß。Embryonic Neuronal CulturesEmbryonic neurons were cultured using an adapted protocol from Ransom and colleagues。Loss of YFP Fluorescence Correlates with Marke...

摘要：【摘要】 Receptor activator of nuclear factor-B (RANKL)-mediated osteoclastogenesis plays a pivotal role in inflammatory bone resorption。 The aim of this study was to identify the cellular so...

摘要：【摘要】 Preterm birth is a major contributor of adverse perinatal outcome。 Clinical data suggest that an inflammatory response is important in the process leading to preterm labor。 By using...

摘要：ResultsInfection with Two Isolates of RSV Exhibits Differences in Pathophysiological ResponsesPrevious studies with mouse models of RSV have identified divergent responses in AHR, mucus, and immune...

摘要：【摘要】 Systemic sclerosis (scleroderma) is an autoimmune disease characterized by excessive extracellular matrix deposition in the skin。 A direct role for B lymphocytes in disease developme...

摘要：We have studied this using an experimental co-infection model in C57BL/6 mice involving Schistosoma mansoni and Leishmania donovani, two important human pathogens affecting the liver。 mansoni infe...

摘要：【摘要】 Lysosomal acid lipase (LAL) hydrolyzes cholesteryl esters and triglycerides to generate free fatty acids and cholesterol in the cell。6,8Liver Extraction and Lysosomal Acid Lipase Act...

摘要：【摘要】 Molecular mechanisms mediating group A Streptococcus (GAS)-host interactions remain poorly understood but are crucial for diagnostic, therapeutic, and vaccine development。1 Substanti...

摘要：Bone-specific analyses included: new bone area using Image Pro Plus version 5。Increasing Bone Formation in Nell-1 Stimulated Calvarial DefectsTo analyze the ability of Nell-1 to induce bone regene...

摘要：Here, we show that JAB1 is a critical regulator of the TNF--mediated anti-apo-ptosis pathways in RA FLSs。 We found that knockdown of JAB1 using small interfering (si)RNA led to restoration of the ...

摘要：【摘要】 We investigated the expression of estrogen receptors (ERs), insulin-like growth factor 1 (IGF-1), and IGF-1R (receptor) in human cholangiocarcinoma and cholangiocarcinoma cell lines (...

摘要：【摘要】 Hepatic stellate cells (HSCs) are key cellular components of hepatic wound healing and fibrosis。 This study addresses the potential for the serotonin (5-HT) system to influence HSC b...

摘要：【摘要】 Insulin resistance induces nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH)。--------------------------------------------------------------------------------No...

摘要：【摘要】 Cellular senescence of biliary epithelial cells with p16INK4a and p21WAF1/Cip expression in damaged small bile ducts may be critical for progressive bile duct loss in primary biliary ...

摘要：【摘要】 Epidermal growth factor receptor (EGFR) is a critical mediator of several types of epithelial cancers。 Recent data indicate that in addition to cognate ligands, EGFR is activated by ...

摘要：【摘要】 Odontogenic keratocysts in humans are aggressive, noninflammatory jaw cysts that may harbor PTCH1 mutations, leading to constitutive activity of the embryonic Hedgehog (Hh) signaling ...

摘要：Isolation of Skin MCs90% skin MC)。ResultsET-1 Levels and Skin Inflammation Is Increased in UV-Irradiated SkinTo test whether ET-1, a potent promoter of UV-induced tanning, is also involved in earl...

摘要：【摘要】 Psoralen plus UVA (PUVA) is used as a very effective treatment modality for various diseases, including psoriasis and cutaneous T-cell lymphoma。--------------------------------------...

摘要：We hypothesized that Kupffer cells are the main source of monocyte chemoattractant protein-1 (MCP-1) production after trauma-hemorrhage, that administration of 17ß。 Prior Kupffer cell depleti...

摘要：Carbon monoxide is also endogenously produced throughout the body with important physiological functions including platelet aggregation, anti-inflammatory actions, and smooth muscle relaxation。Car...

摘要：【摘要】 Bcl-2-associated athanogene 3 (BAG3) is a member of a conserved family of cyto-protective proteins that bind to and regulate Hsp70 family molecular chaperones。 Here, we show that BAG...

摘要：4 Inhibition or loss of P- or E-selectins lead to a significant reduction in neutrophil rolling and acute emigration in many inflammatory models, such as the Arthus reaction, dermal inflammation, a...

摘要：【摘要】 Peroxisomal proliferator-activated receptor (PPAR)- is a ligand-activated transcriptional factor that regulates genes involved in lipid metabolism and energy homeostasis。------------...