摘要：【关键词】 molecular epithelial regulation The Epithelial BarrierOne critical function of epithelial-lined surfaces is to define the interface between separate body compartments。Barrier Functio...

摘要：Here, we studied the effects of platelet-derived growth factor receptor-ß。 blockade in vivo using the platelet-derived growth factor receptor (PDGFR)-ß。 Using a collagen type I transgen...

摘要：【摘要】 Neutrophil gelatinase-associated lipocalin (NGAL) has recently emerged as an important modulator of cell homeostasis。-Induced NGAL and MMP-9 Expression in SMCsInduction of NGAL in SM...

摘要：【摘要】 Serum osteoprotegerin (OPG) is significantly increased in diabetic patients, prompting expanded investigation of the correlation between OPG production/release and glycemic levels。 S...

摘要：CD133+ cells were isolated from 30 human renal carcinomas and characterized as renal resident progenitor cells on the basis of the expression of renal embryonic and mesenchymal stem cell markers。 ...

摘要：To investigate potential roles for caveolin-1 (cav-1) in development, cav-1 and -1ß。 Cav-1 and -1ß。 Morphant phenotypes were rescued by injection of homotypic (cav-1/cav-1) but not hete...

摘要：Am J Pathol 2004, 165:1449-1460Tan JC, Rabkin R: Suppressors of cytokine signaling in health and disease。 Prostate 2002, 51:241-246Dey BR, Furlanetto RW, Nissley P: Suppressor of cytokine signalin...

摘要：【摘要】 Heme oxygenase-1 (HO-1), a cytoprotective enzyme, can be induced in tumors in response to anti-cancer therapies。 Overexpression of HO-1 after transduction with adenoviral vectors inc...

摘要：9Mammalian target of rapamycin (mTOR) is a serine-threonine protein kinase that belongs to the phosphoinositide 3-kinase (PI3K)-related kinase family。10,16,17 Activation of PI3K/AKT has been found...

摘要：Ablation of vitamin D from Fgf-23C/C mice resulted in further reduction of total bone mineral content and bone mineral density and reversed ectopic calcification of skeleton and soft tissues, sugge...

摘要：61Dystrophin- or dysferlinopathies share a common feature of pathophysiology involving sarcolemmal instability attributable to either the compromised cytoskeletal-extracellular linkage normally mai...

摘要：【摘要】 To understand better how diabetogenic CD4+ T cells induce islet ß。-cell death and cause diabetes, a transfer model of acute diabetes using the diabetogenic CD4+ BDC2。-cell deat...

摘要：【摘要】 Dendritic cells (DCs) can release microvesicles, but the latter。--------------------------------------------------------------------------------Dendritic cells (DCs) are antigen-pres...

摘要：Microgliosis and Macrophage Infiltration during EAEImmune-mediated myelin injury requires the involvement of microglia and macrophages as well as autoreactive T cells。

摘要：To accomplish this, we mated IL-13-inducible lung transgenic mice with mice deficient in eosinophil chemoattractant molecules (eotaxin-1, eotaxin-2, and their receptor CCR3) and with mice genetical...

摘要：31Organotypic Culture of Human Testis ExplantsThe protocol was approved by the local ethics committee of the University of Rennes, and informed consent was obtained from the donors。ResultsHIV Rece...

摘要：Proc Natl Acad Sci USA 1998, 95:2469-2474Beckman JS, Koppenol WH: Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly。 Circulation 2001, 103:18-21Schaffer MR, Efron PA, Thornt...

摘要：Oval cells in this case have been regarded as facultative liver stem cells capable of differentiating into both hepatocytes and bile duct epithelial cells。 Recombinant adenoviruses were enriched a...

摘要：【摘要】 Ectodysplasin (Eda) and its receptor (Edar) are required for normal development of several ectodermal derivatives including hair follicles (HFs)。 Here, we show that during the murine...

摘要：Growth of KM12SM cells implanted in the subcutis (ectopic site) of nude mice。 A and B: Expression of PDGF-Rß。 Med Clin North Am 2000, 84:1163-1182Ito M, Yoshida K, Kyo E, Ayhan A, Nakayama H...

摘要：【摘要】 Obesity and insulin resistance accelerate the progression of fibrosis during chronic liver disease。 Up-regulation of resistin during chronic liver damage was confirmed by immunohisto...

摘要：Mucins are found within the insoluble matrix of gallstones。10-12Mucins comprise membrane-bound mucins that are primarily located at the cell surface and gel-forming mucins that are secreted and re...

摘要：Angiogenic cytokine production has been reported to be elevated during IBD, possibly governing increased neovascularization during disease。3% Dextran Sodium Sulfate (DSS) and CD4+CD45RBhigh T-Cell...

摘要：Signal intensity was determined by densitometry and is shown as the mean 。 Signal intensity was determined by densitometry and is shown as the mean 。

摘要：Membrane potentials were measured in the current-clamp mode。ResultsK+ Currents and Membrane Capacitance of Isolated M。

摘要：It localized instead in the cytoplasm in a diffuse pattern without a distinct association with the Golgi apparatus。 When overexpressed, however, wild-type OPTN-green fluorescent protein (GFP) form...

摘要：Expression of ET-1 mRNA was corrected for ß。ResultsGb3 Receptor Expression in Differentiated Murine PodocytesIn line with previous studies in human podocytes,8 differentiated murine podocytes...

摘要：Mitochondrial DNA and mRNA LevelsThe mtDNA content in infected murine hearts was examined by Southern blot analysis。 Mol Aspects Med 2004, 25:211-220Turrens JF: Mitochondrial formation of reactive...

摘要：J Cell Sci 2001, 114:1613-1623Song QH, Gong H, Trinkaus-Randall V: Role of epidermal growth factor and epidermal growth factor receptor on hemidesmosome complex formation and integrin subunit beta4。

摘要：Galectin-3 was also detected for the first time in the centrosome/primary cilium, which has been implicated in diverse polycystic kidney disease。 Galectin-3 genotyping for samples on the 129sv and...

摘要：Dietary sources of -3 PUFAs include mainly fish oils rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid and vegetable (eg, soybean, canola, walnut, and flaxseed) oils rich in -linolenic a...