摘要:21APC/C Substrates Are Frequently Overexpressed in Malignant TumorsBecause the extent of misregulation of APC/C substrates in human neoplasms is largely unknown, we surveyed APC/C misregulation in ...
08-05-29摘要:Overexpression of Mig-7 increased 2 chain domain III fragments known to contain epidermal growth factor (EGF)-like repeats that can activate EGF receptor。 Carcinoma cell adhesion to laminins was s...
08-05-29摘要:【摘要】 Inflammation can play a regulatory role in cancer progression and metastasis。 Previously, we have shown that metastatic tumor cells entering the liver trigger a proinflammatory respo...
08-05-29摘要:【关键词】 histological expression existence hierarchy hepatocellular carcinoma Materials and MethodsHistological StudiesCase SelectionA total of 40 cases of normal liver, dysplastic nodules, an...
08-05-29摘要:Phenotypic Tumor Reversion with PI3K Inhibitor and or Dibutyryl-cAMPCells were seeded on Matrigel as described above, overlaid with 2。Phenotypic Tumor Reversion with Antibodies to ECM ProteinsCell...
08-05-29摘要:s disease (PD) and dementia with Lewy bodies (DLB) are both characterized pathologically by the presence of neuronal inclusions termed Lewy bodies (LBs)。 A common feature found in LBs are aggregat...
08-05-29摘要:Antibodies Used for Flow CytometryT-Cell ProliferationEight-week-old female C57BL/6 mice were immunized on each side at the base of the tail with 100 µ。Macrophage/Microglial Response in the D...
08-05-29摘要:Because Notch signaling regulates the differentiation of neuroectodermal cells during development, we examined the role of Notch signaling in Ewing sarcomas。 We found that Ewing sarcomas express N...
08-05-29摘要:CNS Fractalkine (CX3CL1) Expression by ELISA AssayWe followed the protocol outlined by Huang and colleagues。Neuronal Microglia Co-Culture PreparationNeuronal cultures were prepared as follows。Inc...
08-05-29摘要:【摘要】 There is convincing evidence that Runx2 could be a regulator of the anabolic action of parathyroid hormone (PTH) in bone。 We therefore decided to determine how Runx2 overexpression i...
08-05-29摘要:2,3Lithium is a potent inhibitor of GSK-3 and is commonly used for the treatment of bipolar disorder and seems to be well tolerated in humans。7-9Lithium holds great promise as a potential therapy ...
08-05-29摘要:5), the mouse Pomt1 gene is expressed in the tissues most severely affected in WWS, the muscle, eye, and brain。 In this study, we show that mPomt1 expression is maintained in the muscle and eye in...
08-05-29摘要:Thus, the loss of P- or E-selectin suppressed inflammatory responses during the chronic phase of the chronic models, whereas early-phase inflammatory responses were exacerbated by E-selectin blocka...
08-05-29摘要:【摘要】 Malaria pigment hemozoin was reported to activate the innate immunity by Toll-like receptor (TLR)-9 engagement。 Malaria pigment hemozoin from the Plasmodium falciparum parasite has r...
08-05-29摘要:Cells were then washed twice with PBS and immunoreacted with goat anti-mouse horseradish peroxidase-conjugated IgG (horseradish peroxidase) (Amersham Bioscience, London, UK) for 60 minutes at room ...
08-05-29摘要:In the pituitary, FGFR2 is expressed primarily as the IIIb isoform in normal adenohypophysial cells。 In contrast, FGFR2 is significantly down-regulated in mouse corticotroph AtT20 tumor cells wher...
08-05-29摘要:【摘要】 The infection of T cells by Epstein-Barr virus (EBV) may result in hemophagocytic syndrome (HPS) through enhanced cytokine secretion, particularly tumor necrosis factor- (TNF-), by EB...
08-05-29摘要:【摘要】 Homeobox genes control developmental patterning and are increasingly being found to be deregulated in tumors。12DLX4 is a member of the DLX family of mammalian homeobox genes that are...
08-05-29摘要:Dysregulation of Endogenous DNMT1 Correlated with MAD2 Overexpression and RB Pathway Inactivation in U2OS, MCF-7, HMECs, MCF-10A, PRECs, and HCT116 CellsTo correlate MAD2 expression with the impair...
08-05-29摘要:【摘要】 Tissue plasminogen activator (tPA) is overexpressed in pancreatic ductal carcinoma and is involved in tumor progression。 FASEB J 2004, 18:1398-1400Medina MG, Ledesma MD, Dominguez JE...
08-05-29摘要:These data suggest that in vivo luteogenic hormones, in part through a VEGF-dependent mechanism, stimulate selected integrin-matrix adhesive interactions that promote the motility and survival of G...
08-05-29摘要:Quantitation of Effects of ER-C/PgRC or ER-+/PgR+ Tumor-Derived Fibroblasts on Three-Dimensional Growth and Hormonal Responsiveness of Breast Cancer CellsThree-dimensional cultures were set up by m...
08-05-29摘要:【摘要】 Fibulin-2, an extracellular matrix protein expressed by normal epithelia, was found to be down-regulated in several breast cancer cell lines。 Fibulin-2 protein expression was also de...
08-05-29摘要:13 Proteins were revealed and quantified using Image J software (National Institutes of Health, version 1。 Protein lysates from placentas cultured under H/R in the presence or absence of vitamins ...
08-05-29摘要:【摘要】 Apoptosis is a teleologically beneficial form of cell death in acute pancreatitis。 Our previous work has demonstrated that induction of pancreatic acinar cell apoptosis by crambene p...
08-05-29摘要:【摘要】 In view of the possibility that ricin may be used as a bioweapon against human populations, we examined the pathological consequences that occur in mice after introduction of ricin in...
08-05-29摘要:CXCL16 is a recently discovered chemokine that is expressed as a transmembrane protein that is cleaved to form the active, soluble chemokine。 We analyzed the role of CXCL16 in the development of i...
08-05-29摘要:Evaluation of Glomerular Endothelial Charge BarrierThe endothelial cell surface coat (known as the glycocalyx), which is composed of negatively charged proteoglycans and glycosaminoglycan, has been...
08-05-29摘要:【摘要】 Smads are intracellular signaling proteins that transduce signals elicited by members of the transforming growth factor (TGF)-ß。 Smad5 and Smad1 are highly homologous, and they ...
08-05-29摘要:【摘要】 Sepsis remains a critical problem with significant morbidity and mortality even in the modern era of critical care management。 Multiple derangements exist in sepsis involving several...
08-05-29摘要:Secondary glioblastomas develop through progression from low-grade diffuse astrocytoma or anaplastic astrocytoma and manifest in younger patients。 Primary and secondary glioblastomas also differ s...
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