摘要：【摘要】 Human atherosclerotic plaques express the metalloprotease tumor necrosis factor (TNF)- converting enzyme (TACE/ADAM-17), which cleaves several transmembrane proteins including TNF and...

摘要：Serum apelin-12 (Phoenix Pharmaceuticals, Belmont, CA) or monocyte chemoattractant protein-1 (MCP-1) (R&D Systems, Minneapolis, MN) were measured by enzyme-linked immunosorbent assay。

摘要：--------------------------------------------------------------------------------Endothelial cells (ECs) line the inner wall of arteries and play a central role in atherogenesis。Quantification of e...

摘要：【摘要】 The present study examined the effects of cartilage oligometric matrix protein angiopoietin-1 (COMP-Ang1) on the revascularization of mice skin grafts。 Full-thickness skin grafts wer...

摘要：3-5 Modification of thiols in Trx1 interrupts signaling mechanisms involved in cell growth, proliferation, and apoptosis。14Determination of Modifications of Trx1 by Western Blotting under Native C...

摘要：【摘要】 ß。-2-Glycoprotein 1, an abundant plasma glycoprotein, binds anionic cell surfaces and functions as a regulator of thrombosis。 Collectively, these data indicate that plasmin-cle...

摘要：Proteomic reverse phase arrays were also performed on protein extracts of bladder cancer cell lines of known TP53 status。 Mol Carcinog 2000, 28:12-22Nishizuka S, Charboneau L, Young L, Major S, Re...

摘要：【摘要】 Snai2, encoded by the SNAI2 gene, has been shown to modulate epithelial-mesenchymal transformation (EMT), the conversion of sessile epithelial cells attached to adjacent cells and to ...

摘要：【摘要】 Both tumor cell proliferation and metastasis are dependent on myosin II。 Because UNC-45 is required to chaperone the assembly of a functional myosin II motor, we examined the express...

摘要：Caveolin-1 therefore has the potential to be a marker of tumor vasculature maturity that may help adjusting anticancer therapies。 Tumor slices or cells were examined with an Axioskop microscope (Z...

摘要：ADAM12 has previously been shown to alleviate the pathology of young dystrophin-deficient mdx mice, a model for Duchenne muscular dystrophy。 The observed effect of ADAM12 was suggested to be media...

摘要：--------------------------------------------------------------------------------Colorectal cancer is one of the most common causes of cancer death in Western countries。Liver Metastases Represent a...

摘要：Targeting Inflammatory Demyelinating Lesions to Sites of Axonal Damage in Mice Infected with TMEVThree weeks after intracerebral infection, mice were divided into three groups and received i) no tr...

摘要：Similarities of function and surface markers have been established between Tck cells and a population of T cells that are abundant in RA synovia。 Co-culture times were between 24 and 72 hours depe...

摘要：6 hamsters and mdx mice), we found that Na+/H+ exchanger (NHE) inhibitors prevented muscle degeneration。 NHE activity was constitutively enhanced in BIO myotubes, as evidenced by the elevated intr...

摘要：IARC Monogr Eval Carcinog Risks Hum 1997, 69:1-631Yoon BI, Hirabayashi Y, Kawasaki Y, Kodama Y, Kaneko T, Kanno J, Kim DY, Fujii-Kuriyama Y, Inoue T: Aryl hydrocarbon receptor mediates benzene-indu...

摘要：【摘要】 CCL21 is a homeostatic lymphoid chemokine instrumental in the recruitment and organization of T cells and dendritic cells into lymphoid T areas。 In human secondary lymphoid organs (S...

摘要：Isolation of Oval Cells for Northern Blot AnalysisIsolation of oval cells was performed using control liver, and animals were treated according to the AAF/PHx protocol (18 mg/kg/day) and sacrificed...

摘要：【摘要】 Trefoil factor family 2 (TFF2) is up-regulated in Helicobacter spp。-infected gastric tissues of both humans and mice。 To ascertain the biological effects of TFF2 in vivo, TFF2C/C C5...

摘要：【摘要】 Fas-Fas ligand (FasL) interaction and apoptosis are important in the mechanism of allograft rejection。 However, the interaction between donor and recipient cells, specifically focusi...

摘要：【摘要】 Cables is a cyclin-dependent kinase-binding nuclear protein that maps to chromosome 18q11-12。 Here, we assessed Cables expression in 160 colorectal cancers (CRCs), its role in colon ...

摘要：7,10-12 Survivin has been implicated in binding of the microtubules of the mitotic spindle, centromeres, kinetochores, and intracellular midbodies, enabling coordinated cellular division。13,14 Sur...

摘要：【摘要】 Clusterin is a secreted glycoprotein with stress-induced expression in various diseased and aged tissues。-----------------------------------------------------------------------------...

摘要：【摘要】 Pancreatic secretory trypsin inhibitor (PSTI) is a serine protease inhibitor, expressed in gut mucosa, whose function is unclear。-----------------------------------------------------...

摘要：【摘要】 Decorin, a proteoglycan that inhibits active transforming growth factor-ß。, is increased in diabetic nephropathy。 Decorin gene dose had no effect on severity of diabetes。 howe...

摘要：【关键词】 ultraviolet irradiation hyaluronic down-regulation hyaluronic synthases Materials and MethodsUV Irradiation of MiceCL57/BL6 mice were housed according to standard procedures。UV Irrad...

摘要：【摘要】 Increased expression of Goodpasture antigen-binding protein (GPBP), a protein that binds and phosphorylates basement membrane collagen, has been associated with immune complex-mediate...

摘要：【摘要】 Fibroblast growth factor-2 (FGF2, bFGF) has been proposed to regulate wound healing and angiogenesis, but skin wound healing in FGF2-knockout (FGF2-KO) animals is only slightly delaye...

摘要：--------------------------------------------------------------------------------Valve interstitial cells (VICs) are the most prevalent cells in the heart valve and are found in all three layers of ...