摘要：New Insights into the role of the adenosine triphosphate-binding cassette transporters in high-density lipoprotein metabolism and reverse cholesterol transport。

摘要：From the Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif。 Correspondence to Dr Mohamad Navab, Room 47-123 CHS, Division of Cardiology, Department of Medicine, D...

摘要：1 Despite these statistics, a national survey in 2003 by the American Heart Association (AHA) showed that less than half of all women know that CVD is their leading cause of death。 The expert pane...

摘要：1,2 Protection of the vascular endothelium against harmful influences of circulating substances including excessive levels of lipids has been a major therapeutic approach in prevention of atheroscl...

摘要：What Factors Might Trigger Suppression of TGF-。 Factors affecting the activation of TGF-。 Transforming growth factor-beta and the protection from cardiovascular injury hypothesis。 Transforming g...

摘要：69 Endothelial migration, in turn, was found to be associated with eNOS phosphorylation and activation by the protein kinase Akt。82,83Vascular Endothelial Growth FactorAs the important role of vas...

摘要：uk AbstractNitric oxide (NO), produced by endothelial nitric oxide synthase (eNOS), is a key signaling molecule in vascular homeostasis。 superoxide IntroductionNitric oxide (NO), produced by endot...

摘要：24Differentiating Between Prebeta-Migrating Discoidal HDL and Prebeta-Migrating, Monomolecular, Lipid-Poor ApaA-IBoth monomolecular, lipid-free/lipid-poor apoA-I and discoidal apoA-I-containing HDL...

摘要：ThompsonATVB In FocusAbdominal Aortic Aneurysms: Pathophysiological Mechanisms and Clinical ImplicationsPrevious Brief Reviews in this Series:。 Characteristics of Mouse Models of Abdominal Aortic ...

摘要：edu AbstractThe vascular insulin-like growth factor (IGF)-1 system includes the IGFs, the IGF-1 receptor (IGF-1R), and multiple binding proteins。 The effects of IGF-1 are mediated principally thro...

摘要：uk AbstractObjective— Increased production of reactive oxygen species and loss of endothelial nitric oxide (NO) bioactivity are key features of vascular disease states such as atherosclerosis。 Te...

摘要：uk AbstractObjective— Failure of saphenous vein grafts remains a major limitation of coronary bypass surgery。 The aims of the present study were to determine whether pressure distension of human ...

摘要：From the Vascular Health Research Centre (E。 Cummins, PhD, Vascular Health Research Centre, Faculty of Science and Health, Dublin City University, Glasnevin, Dublin 9, Ireland。 Cyclic strain also...

摘要：jp AbstractObjective— The region of the 110 kDa regulatory subunit (MYPT1) of smooth muscle myosin phosphatase involved in the regulation of contraction was determined under physiological conditio...

摘要：edu AbstractObjective— Vein graft disease involves neointimal smooth muscle cells, the origins of which are unclear。 This study sought to characterize and quantitate vein graft infiltration by ce...

摘要：Bone Marrow TransplantationFemurs of male or female, 8- to 12-week-old GFP-transgenic mice were dissected, and surrounding muscle tissue was removed by microscissors。 Bones were then left in Dulbe...

摘要：nl AbstractObjective— Plasmin activates several proinflammatory pathways at the cellular level in vitro。Tranexamic acid (Cyklokapron) is a synthetic antifibrinolytic substance, which acts by comp...

摘要：Conclusions— Orange juice fortified with plant sterols are effective in reducing LDL cholesterol and could easily be incorporated into the therapeutic lifestyle changes dietary regimen。 Plant ste...

摘要：Preparation of 3H- and 14C-Labeled LipoproteinsLabeled lipoproteins were prepared similarly to the method described previously。 Lipoprotein subfractions were obtained by sequential ultracentrifuga...

摘要：Dietary AnalysesThe baseline dietary intakes were calculated from 4-day food records using the Nutrica software (Social Insurance Institution, Helsinki, Finland) based on the Finnish nutrient datab...

摘要：Methods and Results— Adipophilin mRNA expression was 3。 Adipophilin, or adipose differentiation-related protein (ADRP), a 50-kDa protein initially described in adipocytes,12 which is considered a...

摘要：12,13Cell cycle phases are coordinated by regulatory proteins denoted as cyclins and cyclin-dependent kinases (CDKs)。Cell Cultures and TransfectionsHuman endothelial cells (EC) were isolated and c...

摘要：and the Laboratory of Cellular Biochemistry (A。jp AbstractObjective— Release of cellular cholesterol and phospholipid mediated by helical apolipoprotein and ATP-binding cassette transporter (ABC)...

摘要：fr AbstractObjective— Hyperalphalipoproteinemia (HALP) is characterized by elevated plasma levels of high-density lipoprotein (HDL) particles with altered composition, metabolism, and function。 T...

摘要：17–24 Essential roles of MCP-1 and its interactions with its receptor (CCR2) in AngII-induced arteriosclerosis are shown in CCR2-deficient mice。 New Anti-Monocyte Chemoattractant Protein-1 Gene T...

摘要：Macrophages were identified by staining with a mouse anti-human CD68 antibody (Dako, Glostrup, Denmark)。 ResultsC-Peptide Deposits in Early ArterioscleroticLesions in Diabetic SubjectsTo examine t...

摘要：Telomere shortening has been shown to be associated with cell turnover。Methods and Results— Coronary endothelial cells were obtained from 11 patients with CAD who underwent autopsy and 22 patient...

摘要：and the Human Genetics Division (S。5 Cystatin C is a 13-kDa protein consisting of 120 amino acids and is encoded by a 7。 MethodsGene SequencingFour PCR fragments spanning the proximal promoter, t...

摘要：Methods and Results— Small dense LDL-C was measured by a direct homogenous LDL-C assay in the supernatant that remained after heparin-magnesium precipitation with density 1。 Clinically significan...

摘要：1Proteoglycans contain long carbohydrate side-chains of glycosaminoglycans, which are covalently attached to a core protein by a glycosidic linkage。

摘要：Conclusions— Oral CEE at a low dose of 0。 A, Effect of conjugated equine estrogen (CEE) at a dosage of 0。 B, Effect of conjugated equine estrogen (CEE) at a dosage of 0。 Effects of estrogen rep...

摘要：Stroke was defined as cases coded 430 (subarachnoid hemorrhage), 431 (intracerebral hemorrhage), 434 (ischemic stroke), or 436 (unspecified stroke) according the ICD。Mortality, Stroke, and Cardiac...

摘要：uk AbstractObjective— Inflammation markers and low birth weight each predict elevated risk of cardiovascular events and type 2 diabetes。 However, potential associations between the low-grade infl...

摘要：From MRC National Survey of Health and Development, University College London Medical School, Department of Epidemiology and Public Health, London, UK。Methods and Results— Lipid levels were obtai...

摘要：14 Platelets not only contain voltage-operated potassium channels (Kv channels)15 but also calcium-activated potassium channels (KCa channels), so they are potential targets of EETs。Endothelial Ce...

摘要：6,7 Heme oxygenases are the rate-limiting enzymes in the catabolism of heme into bilirubin, free iron, and CO and exist in different isoforms。 Vascular smooth muscle cells and, particularly, arter...

摘要：ResultsExpression of COX-1 and COX-2 in Human Megakaryocytes and Platelets Differentiated From CD34+ CellsCD41 was substantially expressed at day 8 after induction by TPO and KL。Involvement of TXA...

摘要：Collagen’s weak antigenicity makes it an attractive candidate for stent coatings or fabrication of vascular grafts。Methods and Results— Collagen was heparinized by crosslinking collagen with ext...

摘要：Centers for Disease Control and Prevention。 Therapy with hydroxymethylglutaryl coenzyme a reductase inhibitors (statins) and associated risk of incident cardiovascular events in older adults: evid...