摘要：Endothelial nitric oxide synthase (eNOS) is one of three NOS isoforms that catalyze the formation of nitric oxide (NO) and L-citrulline by the oxidation of the guanido-nitrogen group of L-arginine。...

摘要：It is generally accepted that blockade of the Angiotensin (Ang) II type 1 receptor (AT1) preserves cardiac function after myocardial infarction, and the authors previously demonstrated that left ve...

摘要：6See page 677Redox Control by Each Nox Is Likely to Be LocalizedLocalization of ROS-producing oxidases influences the function of both the signaling mechanisms, which activate the specific oxidases...

摘要：From Centre for Cardiovascular Genetics (S。 and The Centre for Cardiovascular Disease Prevention (P。), Divisions of Cardiovascular Diseases and Preventive Medicine, Brigham and Women’s Hospital,...

摘要：Roles of ROR in the Vascular SystemROR has been shown to be involved in the differentiation of SMC, in the control of the vascular tone of small arteries, in ischemia-induced angiogenesis, in lipid...

摘要：and Center for Liver, Digestive, and Metabolic Diseases (F。 Steatosis occurs when “input“ exceeds the capacity for “output。Extrahepatic Causes of SteatosisA major cause of steatosis is increas...

摘要：Expansive remodeling (E) is then found present when: (vessel area R1+R2)/2 vessel area culprit lesion。 Expansive remodeling is often associated with the presence of atheroma and inflammatory cells...

摘要：Peroxisome proliferator-activated receptor negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-B and AP-1。 Peroxisome proliferator-act...

摘要：ABSTRACTObjective— Angiotensin II is critically involved in left ventricular remodeling after myocardial infarction。 Neovascularization has been thought to prevent the development of left ventric...

摘要：Dystrophin plays a role in flow (shear stress)-mediated endothelium-dependent dilation (FMD) in arteries。Conclusion— Dystrophin deficiency induces a selective defect in flow-dependent mechanotran...

摘要：Nox1 and Nox4, two homologues to the phagocytic NAD(P)H subunit gp91phox, both generate ROS in VSMC but differ in their response to growth factors。 We hypothesize that the opposing functions of No...

摘要：9 Increases in circulating cytokines, especially vascular endothelial growth factor (VEGF), have been shown to mobilize EPCs from bone marrow into the peripheral blood。Effects of Reversible Myocar...

摘要：ABSTRACTObjective— Endothelial differentiation is a fundamental process in angiogenesis and vasculogenesis with implications in development, normal physiology, and pathology。Methods and Results—...

摘要：Orphan nuclear receptors: from gene to function。

摘要：9,15,16 Coactivator associated arginine methyltransferase 1 (CARM-1) binds to the AD2 region of p160 coactivators and enhances gene activation by nuclear receptors synergistically with p160 coactiv...

摘要：Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is widely expressed in vascular cells。 Macrophage migration inhibitory factor is involved in the pathogenesis of col...

摘要：deABSTRACTObjective— CD40 ligand (CD154) expressed on activated T helper cells is a key costimulatory molecule for antigen-presenting cells expressing the corresponding receptor CD40。 Moreover, C...

摘要：cell proliferationIntroductionOxidized low-density lipoprotein (oxLDL) is believed to play a critical role in atherogenesis。 Lipoprotein-depleted serum was prepared as described by Auge et al。 Li...

摘要：Methods and Results— We conducted a prospective, randomized, double-blind, placebo-controlled pilot study of 6 months of SDD or placebo treatment to reduce inflammation and prevent plaque rupture ...

摘要：From the Department of Medicine and Therapeutics (G。N。T。, P。C。, M。Q。, K。S。W。), The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, Hong Kong, China。 Guangdong Prov...

摘要：Very low-density lipoprotein (VLDL) and LDL consist of distinct, physicochemically heterogenic subclasses。 Lipoprotein Profiles of VLDL1 and VLDL2 in Hyperlipidemic FCHL SubjectsLipid Profile of V...

摘要：CXCL16 is a recently discovered chemokine that is expressed in soluble and transmembrane forms, ligates CXCR6 chemokine receptor, and guides migration of activated Th1 and Tc1 cells。 It is identic...

摘要：ABSTRACTObjective— Expression of human apolipoprotein (h-apo) A-IV in apoE-deficient (apoE0) mice (h-apoA-IV/E0) reduces susceptibility to atherosclerosis。 Chronic infection mimicked by exposure ...

摘要：ABSTRACTObjective— By regulating the cellular cholesterol efflux from peripheral cells to high-density lipoprotein, the ABCA1 protein is suspected to play a key role in lipid homeostasis and ather...

摘要：ABSTRACTObjective— Cholesterol 7-hydroxylase (cyp7a1) catalyzes the rate-limiting step in conversion of cholesterol to bile acids。ResultsEffect of cyp7a1 Deficiency on Fecal Sterols and Plasma Li...

摘要：Genetic and environmental factors in the function and structure of the arterial wall。 Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat。 Nat Genet。...

摘要：ABSTRACTObjective— The platelet-derived growth factor (PDGF) family consists of four members, PDGF A, PDGF B, and 2 new members, PDGF C and PDGF D, which signal through the and 。 PDGF receptor (P...

摘要：ABSTRACTObjectives— Secretory phospholipase A2 (sPLA2) enzymes hydrolyze the sn-2 fatty acyl ester bond of phospholipids to produce a free fatty acid and a lysophospholid。 Group V sPLA2 is expres...