摘要：Why Would Gluteal-Femoral Fat Be Cardioprotective。

摘要：), University Medical Center Leiden, The NetherlandsSecond generation thiazolidinediones (TZDs), synthetic ligands for the peroxisome proliferator activated receptor- (PPAR-), have recently been in...

摘要：24–26Imatinib is a tyrosine kinase inhibitor and blocks the activity of the PDGF receptor (PDGFR) and the BCR/ABL oncogene。 Imatinib treatment reduced the total plaque area in the entire aorta in...

摘要：Cell cycle-dependent regulation of smooth muscle cell activation。 Cell cycle inhibition preserves endothelial function in genetically engineered rabbit vein grafts。

摘要：Cholesterol levels and cholesterol turnover are affected in neurodegenerating disorders, and the capacity for cholesterol transport and recycling in the brain seems to be of importance for the deve...

摘要：From Overfeeding to Insulin Resistance: The Role of Oxidative StressThe most important tissues involved in the pathogenesis of insulin resistance are muscle and adipose tissue。38Oxidative Stress a...

摘要：Chemokine-Induced Leukocyte ActivationThe migration of leukocytes across the endothelium is mainly driven by a large family of extracellular ligands: the chemotactic cytokines, better known as chem...

摘要：Moreover, there are still many uncertainties about how cardiovascular risk factors alter CEP function。Endothelial Progenitor Cells: Part of the Inflammatory Response。25More recently, attention ha...

摘要：Cleavage can perturb the functions of FAK and alter its association with other focal adhesion proteins。Cell Adhesion AssayCell adhesion was evaluated as reported previously with slight modificatio...

摘要：MethodsCell CulturePrimary cultures of VSMCs were initiated by enzymatic dissociation from the aortae of 7- to 8-week-old male Sprague-Dawley rats (Charles River Breeding Laboratories, Sulzfeld, Ge...

摘要：ResultsHigh Glucose Increases Monocyte Binding to SEMThe effect of high glucose on monocyte binding to SEM was examined by incubating actively growing HAECs and BAECs in media containing normal (5 ...

摘要：ABSTRACTObjective— Uncoupling protein 2 (UCP2) belongs to the mitochondrial anion carrier family and regulates production of reactive oxygen species in macrophages。Methods and Results— UCP2 over...

摘要：Methods and Results— HDL3 (30 μg/mL) induced COX-2 expression in a time- and dose-dependent manner。 Transient transfection experiments showed that CRE is required for HDL-induced COX-2 transcrip...

摘要：ABSTRACTObjective— We have previously reported increased monocyte adhesion to human aortic endothelial cells (HAECs) cultured in 25 mmol/L glucose (HG) compared with normal glucose (NG) (5。 In th...

摘要：From the Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, 4-1, Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan。ABSTRACTObjective— Vascular endothelial...

摘要：Thalidomide, because of its potent antiinflammatory and immunomodulatory properties, is being re-evaluated in several clinical fields。 Thalidomide administration resulted in a significant reductio...

摘要：Coronary angiographic experiments stimulating vasoconstriction by intracoronary injections of serotonin plus U46619 showed exaggerated prolonged actions amplified by AD, but significant protection ...

摘要：Large artery properties were assessed locally at the level of the transverse aortic arch, globally as total systemic arterial compliance, and also in terms of the augmentation of central systolic p...

摘要：Arterial stiffness also independently predicts all-cause and cardiovascular mortality and may be involved in the process of atherosclerosis。Arterial stiffness is an independent predictor of all-ca...

摘要：From the Hemostasis and Thrombosis Research Centre, Department of Hematology, Leiden University Medical Centre, Leiden, the Netherlands。ABSTRACTObjective— It is generally assumed that C-reactive ...

摘要：Protein binding to the promoter was found to be mediated by an NF1 site between –158 and –145 bp upstream from the transcriptional start site。 Mutation of the NF1 site increased the GFP expressi...

摘要：Tissue inhibition of angiotensin-converting enzyme activity stimulates angiogenesis in vivo。

摘要：Ink PerfusionMice containing implants were anesthetized with Avertin and placed supine on a dissecting stage。

摘要：Effect of Glibenclamide on Resting Coronary ToneIntracoronary glibenclamide infusion at 40 μg/min was not associated with changes in heart rate (69±3 versus 68±3 bpm, P=NS), mean arterial pressu...

摘要：ABSTRACTObjective— Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects。 Humoral, Uri...

摘要：ABSTRACTObjective— Sudden cardiac death (SCD) still remains a serious problem。ResultsSerum Lipid Profiles and Composition of Isolated RLP in the SCD Patients and ControlsPlasma concentrations of ...

摘要：Regional (arms, legs, and trunk) fat tissue (FT) and lean soft tissue (LST) were measured by DXA。Conclusions— Regional body composition information is important for evaluating improvement of CHD ...

摘要：From the Coronary Artery Disease Research Unit (J。 Common carotid IMT together with fasting glucose, insulin, and lipid profile were measured at baseline and repeated after 24 and 48 weeks。 Rosig...

摘要：Imatinib treatment prevented the development of atherosclerotic lesions and diabetes-induced inflammatory cytokine overexpression in the aorta。Imatinib reduced the total lesion area in the diabeti...

摘要：Ceramide decreases transcriptionally active SREBP levels independently of intracellular cholesterol levels。Conclusions— Ceramide synthesis correlates with the generation of transcriptionally acti...

摘要：Cholesterol QuantificationCholesterol analysis was performed as described previously。25Protein QuantificationProtein concentrations were determined on homogenates (as mentioned) using the bicincho...