摘要：The Adult Treatment Panel III (ATP III) of the National Cholesterol Education Program (NCEP) issued an evidence-based set of guidelines on cholesterol management in 2001。 Recent clinical trials su...

摘要：Aortic valve diseases are debilitating cardiovascular disorders associated with significant morbidity and mortality。 Although there continue to be major efforts to improve the longevity of replace...

摘要：13How Do NARC-1 Mutations Cause Familial ADH。 However, this is less likely because the prosegment cleavage site has been indirectly but not conclusively identified at leucine 82 in NARC-1, and all...

摘要：Apart from serendipity, genetics is perhaps our best route to discoveries that elude our intuition。 Genetics establishes a relationship between a gene and a phenotype, but does not necessarily pro...

摘要：CohenATVB In FocusDiabetic Vascular Disease: Pathophysiological Mechanisms in the Diabetic Milieu and Therapeutic ImplicationsABSTRACTReceptor for AGE (RAGE) is a multi-ligand member of the immunog...

摘要：ABSTRACTThe 2 major general concepts about the cell biology of atherogenesis, growth of smooth muscle cells, and lipid accumulation in macrophages, ie, foam cell formation, have not been able to sa...

摘要：ABSTRACTAtherosclerosis is an inflammatory disease characterized by extensive remodeling of the extracellular matrix architecture of the arterial wall。Atherosclerosis is an inflammatory disease ch...

摘要：ABSTRACTBlood vessels express 3 isoforms of superoxide dismutase (SOD): cytosolic or copper-zinc SOD (CuZn-SOD), manganese SOD (Mn-SOD) localized in mitochondria, and an extracellular form of CuZn-...

摘要：Since that time, there has been steady progress in our understanding of coagulation and inflammation, but it is only in the past few decades that the molecular mechanisms linking these 2 biologic s...

摘要：From the Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, Gunma, Japan。ABSTRACTObjective— Transforming growth factor-。1 (TGF。1) and fibroblast growth...

摘要：Smad2, Smad3, and Smad4 proteins are signaling molecules by which TGF-。 during lesion progression in humans by examining the expression of Smads in relation to TGF-。Methods and Results— Immunohi...

摘要：DiscussionVASP Promotes Vascular SMC Proliferation Induced by Serum Only When It Can Be Phosphorylated at Serine157Our data obtained with SMCs from 2 species (mouse and rat) and 2 different express...

摘要：17 Graft function was evaluated by daily palpation。Graft HarvestCardiac allografts of combinations of B/6 and Bm12 (class II mismatch) functioned normally for at least 8 weeks without immunosuppre...

摘要：ABSTRACTObjective— Based on our previous observations on the expression of Tenascin-C (Tn-C) in human atherosclerotic plaques and its colocalization with macrophages, we explored whether Tn-C unde...

摘要：Here, we show that LRP1B, a member of LRs, modulates the migration of smooth muscle cells (SMCs) by increasing the degradation of membrane receptors, urokinase-type plasminogen activator receptor (...

摘要：ABSTRACTObjective— Oxidized low-density lipoprotein (Ox-LDL)is implicated in the pathogenesis of atherosclerosis。 Circulating oxidation-specific epitopes on plasma Ox-LDL has been linked with cor...

摘要：Effects of ramipril and vitamin E on atherosclerosis: the study to evaluate carotid ultrasound changes in patients treated with ramipril and vitamin E (SECURE)。

摘要：MedicationsLarge Artery Stiffness and MMP-9 GenotypeCAD patients that carried a T-allele had significantly higher aortic stiffness as assessed by both input impedance (P=0。Blood Pressure and MMP-9...

摘要：Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes - IL-10 and IL-4 suppress cytokine synthesis by different mechanisms。 Interleukin-10 blocks atheroscl...

摘要：ABSTRACTObjective— Fas ligand (FasL) can induce apoptosis in cells bearing the Fas receptor。 The role of FasL in the vasculature with regard to atherosclerosis is controversial。 This study exami...

摘要：ABSTRACTObjective— Apolipoprotein E (apoE) reduces mouse atherosclerosis progression independent of plasma cholesterol level effects。Methods and Results— ApoE-deficient (apoE–/–), wild-type (W...

摘要：The NARC-1 gene, PCSK9, has been identified recently as the third locus implicated in autosomal dominant hypercholesterolemia (ADH)。 Human, mouse, and rat PCSK9 promoters contain 2 typical conserv...

摘要：), and Vascular Diseases (F。 Incidence of cardiac events showed similar relations with the number of elevated ISPs in obese men。 A cardiac event was defined as nonfatal myocardial infarction (cod...

摘要：modelingIntroductionApolipoprotein B100 (apoB100) plays a central role in intracellular assembly and secretion of triglyceride (TG)-rich lipoproteins1 and is a ligand for low-density lipoprotein re...

摘要：ABSTRACTObjective— Circulating endothelial progenitor cells (EPCs) contribute to postnatal angiogenesis。 The number of circulating EPCs has an inverse correlation with coronary risk scores。 Howe...

摘要：EC Culture and TransfectionHuman umbilical vein ECs (HUVECs。ResultsFunctional Evaluation of Hsp90 Transfection Effects on Postischemic MyocardiumTo evaluate the functional impact of Hsp90 overexpr...

摘要：Endothelial cells native to the aortic valve may play an important role in mediating tissue responses to the complex fluid environment, and may therefore respond to fluid flow in a different manner...

摘要：ABSTRACTThe Adult Treatment Panel III (ATP III) of the National Cholesterol Education Program issued an evidence-based set of guidelines on cholesterol management in 2001。 coronary diseaseThe Exec...

摘要：Power shortage: clinical trials testing the “homocysteine hypothesis“ against a background of folic acid-fortified cereal grain flour。

摘要：Tatsuo YamadaDepartment of Neurology, Fukuoka University School of Medicine, Fukuoka, JapanTo the Editor:Alzheimer disease (AD) is the most common form of dementia, and the central pathogenic event...

摘要：pital de La Pitié-Salpetrière, FranceTo the Editor:In overweight subjects, an elevated supply of intracellular lipid stimulates the microsomal triglyceride transfer protein (MTP)-dependent assemb...

摘要：ABSTRACTObjective— Activated inflammation and activated blood coagulation are believed to increase the risk of coronary thrombosis and are related。 We therefore compared plasma IL-6 (a key cytoki...

摘要：Pravastatin-Induced Regression of Atherosclerotic Lesions in Abdominal AortaThere was no significant difference in the degrees of neointimal formation (intimal area and intima/media ratio) between ...

摘要：Effects of Conventional or Lower Doses of Hormone Replacement Therapy in Postmenopausal WomenResultsBaseline values before C-HRT or L-HRT treatment period were compared。Effects of Therapies on Lip...

摘要：From the Department of Medicine (S。S。A。, E。L。, K。T。, S。Y。), McMaster University, and Population Health Research Institute (S。S。A。, F。R。, Q。Y。, E。L。, K。T。, S。Y。), Hamilton Heal...

摘要：ABSTRACTObjective— To study the role of IL-8 in predicting future coronary artery disease (CAD) in apparently healthy men and women。 We measured baseline IL-8 concentrations among 785 apparently ...