摘要：Since the initial report of the Heart and Estrogen/Progestin Replacement Study (HERS) in 1998, the medical community has struggled to understand the unexpected findings from a series of randomized ...

摘要：From the Québec Heart Institute, Laval Hospital Research Center, Québec, CanadaAlthough epidemiological and clinical studies conducted over the last 40 years have identified variables which becam...

摘要：The initiation and progression of atherosclerosis appears driven by a combination of genetic and environmental factors。 Access to circulating lipoproteins or to molecules shed into the blood from ...

摘要：The development of atherosclerotic lesions is a complex process that requires monocyte recruitment to the vascular endothelium。 In response to oxidized lipid accumulation in the vessel wall, endot...

摘要：Hepatic lipase functions as a lipolytic enzyme that hydrolyzes triglycerides and phospholipids present in circulating plasma lipoproteins。 Hepatic lipase also serves as a ligand that facilitates l...

摘要：ABSTRACTHigh-density lipoproteins (HDL) protect against cardiovascular disease。 HDL removes and transports excess cholesterol from peripheral cells to the liver for removal from the body。 HDL als...

摘要：5 Genetic modulation of endothelial function may offer new opportunities to modify the course of common cardiovascular diseases such as hypertension, atherosclerosis, thrombosis, and ischemic arter...

摘要：11Techniques for Identification of Vulnerable PlaqueThe natural history of vulnerable plaques is obviously difficult to infer from autopsy studies, and angiography has its limitations。If Most Pati...

摘要：ABSTRACTObjective— Leukotriene B4 (LTB4), a product of the 5-lipoxygenase (5-LO) pathway of arachidonic acid metabolism, has been implicated in atherosclerosis。Leukotriene B4 (LTB4), a product of...

摘要：In advanced atherosclerotic lesions, lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is expressed in endothelial cells, macrophages, and smooth muscle cells (SMCs)。 In vitro, the e...

摘要：Methods and Results— In human umbilical vein endothelial cells (HUVECs), immunofluorescence revealed strong eNOS membrane staining at the cell–cell junction colocalizing with platelet/endothelial...

摘要：ABSTRACTObjective— Angiopoietin-2 (Ang-2) is a non-signal transducing ligand of the endothelial receptor tyrosine kinase Tie-2。11Expression profiling studies have identified endothelial cells as ...

摘要：ABSTRACTObjective— ADP plays an important role in platelet aggregation by activating P2Y12 receptors。Methods and Results— P2Y12 receptor mRNA was found to have a high expression among the P2 rec...

摘要：Effect of SAH on ADMA-Accelerated Senescence, NOx Synthesis, and Allantoin ProductionTo test whether SAH could attenuate the effect of ADMA (50 μmol/L) on cellular senescence, HUVEC were incubated...

摘要：Oxidized low-density lipoprotein regulates matrix metalloproteinase-9 and its tissue inhibitor in human monocyte-derived macrophages。

摘要：Methods and Results— The regulated in development and DNA damage response 2 (REDD2) gene was strongly upregulated as THP-1 macrophages are converted to foam cells。 Human REDD2 shares 86% amino ac...

摘要：In Vivo LPS MeasurementsAs determined by the limulus amebocyte lysate assay (Figure I, available online at http://atvb。Endothelial Genes Responsive to In Vivo LPS ExposureFigure 3。 Cardiac in sit...

摘要：ABSTRACTObjective— Rho-Kinase activity is increased in cardiovascular diseases and in patients with cardiovascular risk factors。 Activation of Akt and eNOS by HF was completely blocked by the pho...

摘要：ABSTRACTBackground— Carbon monoxide (CO) is postulated to protect tissues against several types of injuries。 We investigated the role of CO in amelioration of cardiac ischemia–reperfusion injury...

摘要：Systemic Characteristics, Single-Kidney Hemodynamics, Micro-CT Analysis, and Morphological Evaluation (Mean±SEM) of the Kidney in Normal, RAS, and Antioxidant-Supplemented RAS PigsCortical Microva...

摘要：ABSTRACTObjective— NADPH, a substrate for the superoxide-producing enzyme NADPH oxidase, produces vasodilation in the cerebral circulation。 We used a peptide inhibitor of NADPH oxidase (gp91ds-ta...

摘要：Conclusions— Oral estrogen increased SAA and altered HDL composition to contain a higher level of SAA by a first-pass hepatic mechanism。 Oral estrogen increased SAA and altered HDL composition to...

摘要：From the Department of Pharmacology, Therapeutics, and Toxicology, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, United Kingdom。ABSTRACTObjective— Although C-r...

摘要：Conclusions— Exercise training with weight reduction disproportionately lowered CRP levels。16,17Exercise training is another therapy that can reduce weight and has protective effects against athe...

摘要：ABSTRACTObjective— The goal of this study is to determine whether C-reactive protein (CRP) gene variants affect baseline and training-induced changes in plasma CRP levels。Methods and Results— Si...

摘要：Mast cells and angiogenesis。 Mast cells accompany microvessels in human coronary atheromas: implications for intimal neovascularization and hemorrhage。 Human mast cell basic fibroblast growth fac...

摘要：6,7,15Gene Transfer Into Skeletal Muscles by In Vivo Electroporation7ND-pcDNA3 plasmid, which encodes 7ND, was constructed as described previously。 Total RNA was prepared with the use of Isogen re...

摘要：3Chemokines have been found to play a major role in neointimal hyperplasia after acute arterial injury。

摘要：hAI Expression Retarded the Size Progression of Atherosclerosis and Altered Lesion CharacteristicsIn the male animals studied here, at all time points, lesion area in the apoE–/– mice exceeded th...

摘要：ABSTRACTBackground— Inhibition of cholesteryl ester transfer protein (CETP) is an efficient way to increase high-density lipoprotein (HDL) levels in humans。 We investigated the effects of the inh...

摘要：ABSTRACTObjectives— Bone marrow-derived vascular progenitor cells (CD34+) are present in human and animal models of abdominal aortic aneurysm (AAA) disease。 CD34+ cells were identified throughout...

摘要：From the Departments of Medicine, Microbiology, Immunology, and Molecular Genetics, and Human Genetics (X。 With respect to atherosclerotic lesions and some lipid parameters, this chromosome 15 gen...

摘要：Sibships in the FCHL Quantitative Trait Locus AnalysesLipid MeasurementsThe lipid measurements were performed in the morning (8:00 AM to 11:00 AM) after an overnight fast (12 to 14 hours)。Linkage ...

摘要：Candidate LDL Size Loci or Related Traits Mapped to Regions Detected (lod3) or Suggested by This Study (lod2。 Lipoprotein distribution in the metabolic syndrome, type 2 diabetes mellitus, and fami...

摘要：Risk factors showing significant univariate correlations with IMT (listed above) were included in respective models for average IMT and each location。Segment-Specific Carotid IMTUnique to our stud...

摘要：7Fibrin D-dimer, a marker of cross-linked fibrin turnover, has also been associated with the risk of future IHD。 Fibrinogen was measured using heat precipitation nephelometry。 Fibrinogen was meas...

摘要：In this study, we analyzed the role of the phosphoinositide 3-kinase (PI3K)-Akt pathway in the activation of coagulation and the innate immune response in a mouse model of endotoxemia。Methods and ...

摘要：ABSTRACTObjective— Lipids, through effects on the coagulation and fibrinolytic systems, may contribute to the development of venous thrombosis。2,3 Risk factors for venous thrombosis may be geneti...

摘要：CorrectionIn the June 2004 issue of Arteriosclerosis, Thrombosis, and Vascular Biology, in the article entitled “Susceptibility to Early Atherosclerosis in Male Mice Is Mediated by Estrogen Recept...

摘要：7 Calcification was found preferentially in plaques with expansive (“positive“) arterial remodeling,10 known to be associated with an increased risk of rupture。 Vascular Calcification。 Mechanis...