摘要:Beginning in 2005, three new investigators will be honored each year for their outstanding papers in Arteriosclerosis, Thrombosis, and Vascular Biology。 The first authors of one original paper eac...
07-05-18摘要:We believe that Arteriosclerosis, Thrombosis, and Vascular Biology is recognized as an appropriate forum for publication of excellent papers related to atherosclerosis, lipoproteins, vascular biolo...
07-05-18摘要:Plasma plant sterols cannot be synthesized endogenously and are completely derived from the diet。 Plant sterol levels are not associated with atherosclerosis in mice and men。
07-05-18摘要:1,2 Cholesterol from modified lipoproteins is taken up and either stored in intracellular lipid droplets or delivered to extracellular cholesterol acceptors。 Cellular free cholesterol can be expor...
07-05-18摘要:From the Howard Hughes Medical Institute and the Department of Pathology and Laboratory Medicine, University of California, Los Angeles。Correspondence to Peter Tontonoz MD, PhD, Howard Hughes Medi...
07-05-18摘要:In this issue of Arteriosclerosis, Thrombosis, and Vascular Biology, Jonsson-Rylander and her colleagues show us that ADAMTS1, a member of another family of proteases, is also involved。4 Descendan...
07-05-18摘要:eduStudies of the large families of seven transmembrane receptors have focused on their signal transduction pathways initiated by their interaction with GTP activated proteins。 Angiotensin II (Ang...
07-05-18摘要:and the Atherosclerosis Research Center and the Division of Cardiology (P。 Hansson AbstractA number of studies have shown activation of the immune system throughout various stages of atheroscleros...
07-05-18摘要:Oxidative stress is the unifying mechanism for many CVD risk factors, which additionally supports its central role in CVD。Oxidative Stress and AtherosclerosisOxygen is an abundant molecule in biol...
07-05-18摘要:uk AbstractVitamin D is generally associated with calcium metabolism, especially in the context of uptake in the intestine and the formation and maintenance of bone。 Vitamin D is likely to have a ...
07-05-18摘要:edu AbstractHow does tissue factor (TF), whose principle role is to support clotting factor VIIa (FVIIa) in triggering the coagulation cascade, affect various pathophysiological processes。 One of ...
07-05-18摘要:Methods and Results— Here we show that the cytoplasmatic carboxy-terminal of the angiotensin AT2 receptor (AT2R) acts independently as an endoplasmic reticulum–export signal。 Using a yeast two-h...
07-05-18摘要:Physiological DataEffect of ACE Inhibition on Postischemic Neovascularization in Hind Limb: MicroangiographyAs expected, blood vessel growth was impaired in diabetic mice compared with control anim...
07-05-18摘要:From the Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology (M。P。, M。B。, E。T。, D。L。, C。U。, A。B。, R。R。, S。N。, E。M。, H。S。, M。C。, G。A。...
07-05-18摘要:ResultsPeriostin Expression Is Increased After Arterial InjurySuppressive subtractive hybridization was conducted on cDNA derived from 8-day balloon-injured rat carotid arteries and control vessels...
07-05-18摘要:5,6 Vasodilatory prostaglandins such as PGI2 and PG E2 (PGE2) mediate various functions in vascular biology including regulation of vascular tone, thrombocyte function, and inflammatory responses。...
07-05-18摘要:Ceramide Produces Endothelial Dysfunction in Nontransgenic MiceIn nontransgenic mice, ACh produced concentration-dependent relaxation of carotid arteries precontracted with U46619 (Figures 2 and 3 ...
07-05-18摘要:Loss of the redox-sensitive domain blocked the ability of Ref-1 to reduce p50。1–3 Work from our group and others has demonstrated that Redox factor 1 (Ref-1) regulates DNA binding of multiple tra...
07-05-18摘要:Methods and Results— Spiral arteries were dissected from nonplacental bed biopsies obtained at Caesarean section, and a novel model was used to mimic in vivo events。 This was blocked by caspase i...
07-05-18摘要:8Adenosine Uptake in Isolated ErythrocytesIn 6 additional healthy volunteers, erythrocytes were isolated for in vitro experiments。 Adenosine recovery of the intramuscular and intravascular probes ...
07-05-18摘要:Hyperhomocysteinemia (HHcy) was defined as tHcy levels 15。 left ventricular ejection fraction IntroductionHyperhomocysteinemia (HHcy) might play a causative role in the development of coronary art...
07-05-18摘要:and the Institute of Human Nutrition (P。 Foam cells of smooth muscle origin are also found in human and animal atherosclerotic lesions。 Rat aortic smooth muscle cells (ASMCs) treated for 48 hours...
07-05-18摘要:Recent studies in our laboratory have shown that the deletion of the macrophage ACAT1 gene results in apoptosis and increased atherosclerotic lesion area in the aortas of hyperlipidemic mice。Metho...
07-05-18摘要:Macrophage and Collagen Content of Atherosclerotic Lesions in LDLR–/– Mice After LXR Agonist TreatmentLXR Regulation of Gene Expression in Atherosclerotic LesionsTo further evaluate the effects o...
07-05-18摘要:de AbstractObjective— High-density lipoprotein (HDL) cholesteryl esters (CE) are taken up by liver and adrenals selectively, ie, independent from particle internalization。 Class B type I scavenge...
07-05-18摘要:From the Section of Endocrinology and Metabolism (K。 Correspondence to Lawrence Chan, Division of Endocrinology Metabolism, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030。edu Ab...
07-05-18摘要:jp AbstractObjective— Heme oxygenase-1 (HO-1), the rate-limiting enzyme of heme degradation, has recently been considered to have protective roles against various pathophysiological conditions。1H...
07-05-18摘要:Conclusion— Low-dose atorvastatin cholesterol-dependently reduces lesion progression in the aortic root but shows antiinflammatory vascular activity and tends to retard atherogenesis in the aortic...
07-05-18摘要:18Lipoproteins were iodinated by the iodine monochloride method。Lipid Accumulation in MPM Cells Exposed to LipoproteinsMPM cells were collected, seeded, and incubated for 1 day as described above ...
07-05-18摘要:smooth muscle cell IntroductionApoptosis, also called programmed cell death, plays a critical role in tissue development and maintenance of homeostasis within multicellular organisms。11,12Macropha...
07-05-18摘要:lndal, Sweden。), Gothenburg, Sweden。, Sweden。lndal, Sweden。
07-05-18摘要:de AbstractObjective— C-Reactive protein (CRP) is the prototype acute phase protein and a cardiovascular risk factor。) and IL-6 stimulate CRP synthesis in hepatocytes。 We searched for additional...
07-05-18摘要:Elevated liver enzymes secondary to hepatic steatosis are frequent in subjects with the metabolic syndrome。19Elevated serum alanine aminotransferase (ALT) levels is the most common liver abnormali...
07-05-18摘要:Annexin V binding to human umbilical vein endothelial cells (HUVECs) as determined by flow cytometry after 24-hour culture with plasma was decreased when plasma from SLE cases was used (SLE cases v...
07-05-18摘要:Quantitative trait locus analysis was performed using 153 polymorphic microsatellite markers spanning the genome。 Quantitative PCR was performed using DyNAmo Hot Start SYBR Green qPCR kit (Finnzym...
07-05-18摘要:ResultsPhenotype of Heterozygous Carriers of LDLR Mutations Identified in the General PopulationThe W23X, W66G, and W556S mutations were identified in 6 of 9255 subjects in the general population (...
07-05-18摘要:Measurement of Lp-PLA2 Mass and ActivityLp-PLA2 mass was measured using a 2-site enzyme-linked immunoabsorbent assay (diaDexus Inc, South San Francisco, Calif) on serum samples stored at –70°C fo...
07-05-18摘要:6 Interleukin-1。 –511 Polymorphisms on IL-1。 GeneORs decreased with the genotypes in the following order: CC (OR=1) CT TT in univariate (P=0。 GeneThe association between the T allele and the ri...
07-05-18摘要:Virtanen, Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland。fi AbstractObjective— Mercury has been suggested to have negative effects on cardiovascular...
07-05-18摘要:Histology Processing and CriteriaCarotid endarterectomy specimens were fixed in 10% neutral-buffered formalin, decalcified, and embedded en bloc in paraffin。 Plaque component specificity ranged fr...
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