摘要：The importance of a healthy lifestyle in reducing the risk of CVD cannot be over-emphasized, with many guidelines offering recommendations on lifestyle issues such as smoking, diet, alcohol, and ph...

摘要：From the Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Canada。caIn humans, apolipoprotein E (apoE) is a polymorphic multifunctional protein。1 It is c...

摘要：Among hematopoietic stem cell–related populations, CD133+, CD34+, and VEGFR+ cells have received a great deal of attention。 To exclude differentiated circulating endothelial cells from a study po...

摘要：eduMuch interest has been generated recently concerning the role of reactive oxygen species (ROS) in vascular health and disease。6 Perhaps more importantly, ROS are essential to the normal functio...

摘要：Redox aspects of vascular response to injury。 Redox control of vascular smooth muscle proliferation。 Mechanisms underlying endothelial dysfunction in diabetes mellitus。 Redox regulation of prote...

摘要：Quantification of IsoPs in Biological FluidsIt is important to note that IsoPs can be quantified in tissues and in biological fluids such as blood and urine。23,30 F2-Isoprostanes as Index of Oxida...

摘要：edu AbstractThe 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A (CoA) reductase inhibitors (statins) have been shown to exhibit several vascular protective effects, including antithrombotic properties,...

摘要：Inward-rectifying K+ channels (KIR) in vascular smooth muscle differ from other vascular smooth muscle K+ channels (Ca2+-activated K+ channels, KCa, voltage-dependent K+ channels, KV, and ATP-sensi...

摘要：gov AbstractObjective— Endothelial progenitor cells (EPCs) that may repair vascular injury are reduced in patients with coronary artery disease (CAD)。 We reasoned that EPC number and function may...

摘要：Differences in gene expression were identified at baseline as well as during normal aging and longitudinal exposure to high-fat diet。 oxidative stress IntroductionMouse strains with different gene...

摘要：edu AbstractObjective— Previous studies suggested the zinc-finger transcription factor GATA-6 inhibits vascular smooth muscle cell (VSMC) proliferation and promotes the contractile VSMC phenotype。...

摘要：From the Institute for Translational Medicine and Therapeutics (B。) and the Department of Medicine, Gastroenterology Division (M。), University of Pennsylvania School of Medicine, Philadelphia。 F...

摘要：de AbstractObjective— Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs)。 cytochrome P450 IntroductionCytochrome P450 epoxygenases of the 2B, 2C, a...

摘要：Fluvastatin restored the decreased expression ratio, and the addition of mevalonate (100 μmol/L) suppressed this recovery。 Fluvastatin treatment also restored the decreased contractility, and the...

摘要：), and the Institute of Anatomy and Cell Biology (Y。Correspondence to Dr Yuh-Lien Chen, Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, No。tw AbstractObje...

摘要：Here we investigated whether c-Src plays a role in TGF-。1 induction of the SMC contractile protein SM22 gene expression was inhibited by PP1 (an inhibitor of Src family kinases) or by C-terminal S...

摘要：it AbstractObjectives— Clusterin is a heterodimeric glycoprotein which is implicated in several biological processes。Methods and Results— Clusterin expression was evaluated by immunohistochemist...

摘要：We recently demonstrated that the inositol 3-phosphatase PTEN is expressed in VSMCs and that its overexpression inhibits these cellular responses。 The purpose of this study was to determine the ef...

摘要：Effects of BSDL on HUVEC migration and motility。 Effects of BSDL on the capillary network formation of HUVECs on Matrigel and involvement of growth factors in proliferation。 C, Effects of antibod...

摘要：Effect of Genetic PAI-1 Deficiency on Aortic Remodeling and Cardiac FibrosisAng II significantly increased systolic blood pressure from 101。 Genetic PAI-1 deficiency protected against Ang II-induc...

摘要：Elastin is the main elastic component of the arterial wall and can be degraded by a number of enzymes, including matrix metalloproteinase-9 (MMP-9) and MMP-2。 Blood pressure, lipids, C-reactive pr...

摘要：Betaine (trimethylglycine) is obtained in small amounts from food6 or is generated from choline。Betaine (fasting and PML) was strongly and positively related to choline and DMG (r=0。Folate, Choli...

摘要：Conclusions— Asymptomatic atherosclerosis is associated with circulating C pneumoniae DNA independently of classical cardiovascular risk factors in normotensive subjects and those 70 years old。 G...

摘要：In the Seven Countries Study in the 1960s1 and in the World Health Organization Monitoring Trends Determinants in Cardiovascular Disease (WHO MONICA) project in the 1980s,2 eastern Finnish men were...

摘要：Effects of a high-fat meal on resistance vessel reactivity and on indicators of oxidative stress in healthy volunteers。 Acute elevations of plasma asymmetric dimethylarginine and impaired endothel...

摘要：Postprandial AUCs for intermediate-density lipoproteins (IDLs) and low-density lipoproteins (LDLs) were higher in group 1 than groups 2 and 3 (all P0。Conclusions— Postprandial clearance of trigly...

摘要：Because inactivation or hyperexpression of APOA5 gene, encoding apolipoprotein A-V (apoA-V), causes a marked increase or decrease of plasma triglycerides in mice, and because some common polymorphi...

摘要：This study was performed to test the reported association between the –565CT polymorphism and atherosclerosis severity and to investigate whether this variant per se had an effect on promoter acti...

摘要：Pitavastatin inhibits RLP-induced macrophage foam cell formation。 Pitavastatin inhibited RLP-induced macrophage foam cell formation, at least in part, via inhibition of apoB48R expression。 Method...

摘要：Macrophages were scattered in the intima but predominantly located on the endothelial surface and subendothelial space。 Granulocyte-macrophage colony stimulating factor (GM-CSF) modulates the expr...

摘要：foam cell IntroductionAtherosclerosis is a dynamic and reversible process。 Atherosclerosis was assessed in all 3 groups。 Atherosclerosis was quantified morphometrically by measuring the extent of...

摘要：From the Departments of Clinical Renal Regeneration and Internal Medicine (K。H。, T。F。), Division of Nephrology and Endocrinology, University of Tokyo, Japan。 and the Department of Pharmacology...

摘要：) and the Division of Nephrology and Hypertension (A。Experimental hypercholesterolemia and hypertension have been associated with metabolic and functional alterations, resembling early-stage cardi...

摘要：Conclusions— Exercise training suppresses the extent of ASIPA, probably by reducing vWF binding to platelets and P-selectin expression on platelets。 Training intensity was adjusted to 60% of VO2m...

摘要：Methods and Results— Factor Xa (FXa) bound to tissue factor pathway inhibitor and prothrombin fragments F1+2 (F1+2) were used as a measure for activated coagulation。 In AMI, tissue factor pathway...

摘要：ResultsCoated Platelets Lose Mitochondrial PotentialJC-1 is a fluorescent dye sensitive to mitochondria potential (m), and quiescent platelets labeled with JC-1 demonstrate an intense FL2 fluoresce...