摘要：Curtiss, Chair of the Leadership Committee of the ATVB Council We would like to congratulate the National Heart, Lung, and Blood Institute (NHLBI) on their appointment of Elizabeth G。 Nabel, MD, F...

摘要：Small, dense low-density lipoprotein particles as a predictor of risk of ischemic heart disease in men: prospective results from the Quebec Cardiovascular Study。 Small, dense LDL and elevated apol...

摘要：eduAortic stenosis (AS) is a relatively common cause of cardiac debility and death, increasing in frequency and severity with age。 Statins but not angiotensin-converting enzyme inhibitors delay pr...

摘要：2See page e22BP Measurement MethodsThe techniques for measuring BP in experimental animals have improved considerably over the past decade, and several methods are available that allow routine moni...

摘要：Given the large amount of interest and activity in this broad area, the editors of Arteriosclerosis, Thrombosis, and Vascular Biology elected to launch a new series of brief reviews entitled “Nove...

摘要：RaderNovel Approaches to the Treatment of DyslipidemiaATVB In Focus AbstractBecause the ability to make triglycerides is essential for the accumulation of adipose tissue, inhibition of triglyceride...

摘要：CohenDiabetic Vascular Disease: Pathophysiological Mechanisms in the Diabetic Milieu and Therapeutic ImplicationsATVB In FocusPrevious Brief Reviews in this Series:。 Overview of PKC Isoform–Speci...

摘要：es AbstractLDL receptor–related protein 1 (LRP1) is highly expressed in the vascular wall and is mainly associated with macrophages and vascular smooth muscle cells (VSMCs)。 Our group has contrib...

摘要：2–4 Estrogens act via at least 2 receptors that are expressed in the vessel wall (ER and ER。Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinghoff E, for the Heart and Estrogen/...

摘要：edu AbstractObjective— Vascular endothelial growth factor (VEGF) is one of the most important pro-angiogenic cytokines。 reactive oxygen species IntroductionVascular endothelial growth factor (VEG...

摘要：ca AbstractObjective— We tested the hypothesis that p47phox associates with the actin cytoskeleton, enabling site-directed activation of NAD(P)H oxidase, and assessed whether these actions influen...

摘要：de AbstractBackground— Human urotensin II (hU-II) is a potent vasoactive peptide possibly involved in pulmonary hypertension。 Because the signaling mechanisms activated by this peptide in the pul...

摘要：From the Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine (R。D。, R。E。, A。I。), Tel Aviv University, Israel。 and the Whitaker Cardiova...

摘要：Vascular injury is also associated with infiltration of inflammatory cells such as leukocytes。 Smooth muscle migration in atherosclerosis and restenosis。

摘要：Glucose upregulated COX-2 protein expression, which was associated with the induction of prostaglandin (PG) E2 (PGE2), caspase-3 activity, and apoptosis。 Glucose-induced activation of PI3K resulte...

摘要：de AbstractObjectives— Sphingosine 1-phosphate (S1P) is a bioactive phospholipid acting both as a ligand for the G protein–coupled receptors S1P1-5 and as a second messenger。Stable silencing by ...

摘要：Lipoprotein and cholesterol metabolism in diet-induced coronary artery atherosclerosis in primates。

摘要：Plasma Lipids and Lipoprotein Fraction PreparationBlood was collected in tubes containing EDTA。 Calculated apoB Pool Size and FCR for Each Lipoprotein FractionThe FCRs for apoB within each lipopro...

摘要：se Abstract Objective— We investigated the role of ADP ribosylation factor 1 (ARF1) in the assembly of very-low-density lipoproteins (VLDLs)。Key Words: ADP ribosylation factor 1 。 Consistent wit...

摘要：Anti-ubiquitin antibody was from Stressgen (Victoria, BC, Canada)。 ResultsGlucosamine-Induced Grp94 and Grp78 Expression Results in a Dose-Dependent Decrease in Cellular and Secreted ApoB100 in He...

摘要：triglyceride IntroductionLipoprotein profiles are well accepted as predictors of risk for coronary heart disease (CHD)。 Clinical Characteristics, Lipid, and Lipoprotein Profiles of 62 MenAnalytica...

摘要：ResultsFF and GF Regulate ApoA-I Differently in HumansTo compare the effects of FF and GF on plasma lipids and apoA-I, 234 patients with combined hyperlipidemia were treated with FF (n=116) or GF (...

摘要：Statins inhibited calcific nodule formation (P0。Conclusions— Statins inhibit calcification in AVMFs by inhibiting the cholesterol biosynthetic pathway, independent of protein prenylation, but par...

摘要：Conclusions— Rosuvastatin attenuates inflammatory processes associated with cerebrovascular disease。 Rosuvastatin was supplied by AstraZeneca, UK。 ResultsEffects of Rosuvastatin on Physiological...

摘要：Uncoupling protein 2 (UCP2) reduces mitochondrial ROS generation and protects against the disease in animal models。-cell function may also affect UCP2 gene expression in cells of the arterial wall...

摘要：Carotid lesions were bilaterally evaluated for plaque composition and plaque morphology。 Plaque composition and morphology differed significantly between the ethno-racial groups。 Carotid lesions ...

摘要：jp AbstractObjective— Growth hormone (GH)–insulin-like growth factor (IGF)-1 axis regulates growth and survival of vascular cells and cardiomyocytes。 Circulating IGF-1 and IGFBP-3 may be stimula...

摘要：org AbstractObjective— Liver X–activated receptor (LXR) regulates multiple genes controlling cholesterol metabolism and transport。 To clarify its role in atherogenesis, we established a monoclon...

摘要：edu AbstractObjective— CD1d-restricted natural killer T (NKT) cells are reported to play a proatherogenic role in the development of atherosclerosis。Methods and Results— We measured lesion size ...

摘要：Conclusion— Oxidized phospholipids contribute to vascular inflammation in murine arteries in vivo, initiating atherogenic chemokine expression that leads to monocyte adhesion。Oxidized phospholipi...

摘要：8,9 Two separate caspase-dependent apoptotic pathways have been implicated in oxLDL-induced apoptosis。Time Course of the Effects of oxLDLs on the Calcium-Dependent Mitochondrial Apoptotic Pathway ...

摘要：Circadian rhythms are the overt expression of an internal timing mechanism measuring daily time, with the fundamental adaptive function of providing optimal temporal organization of physiological p...

摘要：4We examined prospective relationships of adiponectin to vascular disease in a case–control series selected from the Strong Heart Study (SHS)。 Adiponectin showed no significant association with l...

摘要：College of Dental Medicine (E。V。K。), Nova Southeastern University, Fort Lauderdale, Fla。 Center for Molecular Microbiology (E。V。K。, B。R。D。, W。A。D。, A。P。-F。), Department of Oral Biol...

摘要：Innsbruck Medical University, Innsbruck, AustriaTo the Editor:Doggen et al report that low HDL cholesterol and high triglyceride levels are associated with an increased risk for venous thrombosis i...

摘要：Department of Geriatrics and Metabolic Diseases, Second University of Naples, ItalyTo the Editor:We read with interest the articles about the effect of exercise training on C-reactive protein (CRP)...

摘要：Part 2: Blood Pressure Measurement in Experimental Animals。 A Statement for Professionals From the Subcommittee of Professional and Public Education of the American Heart Association Council on Hi...