摘要:eduAlthough P-selectin had already been established as a vascular adhesion molecule critical in the inflammatory response, in 1992 Palabrica et al were the first to demonstrate that P-selectin also...
07-05-18摘要:edu IntroductionThe Receptor for advanced glycation endproducts (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules。 Soluble RAGE: Biomarker or Endogenous P...
07-05-18摘要:nlSince the recognition of basicfibroblast growth factor (bFGF, FGF-2) and acidic FGF (aFGF, FGF-1) as proliferation and maintenance factors for endothelial cells in culture,1,2 much interest has a...
07-05-18摘要:Moreover, VSMCs produce several different superoxide scavenger enzymes located in different areas of the cell: SOD1 (Cu/ZnSOD), which accounts for 50% to 80% of total SOD in blood vessels and is lo...
07-05-18摘要:and the Vascular Medicine and Atherosclerosis Unit (K。1,5,6 In this issue of Arteriosclerosis, Thrombosis, and Vascular Biology, Kim et al demonstrate that treatment of vascular endothelial cells ...
07-05-18摘要:frThe concept that blood pressure influences vessel wall composition and structure is well established。 Any alterations in stretch (caused by changes in blood pressure) solicit counteracting radia...
07-05-18摘要:edu AbstractThis review considers the role of macrophage cell death in formation of the necrotic core and in plaque progression, and lists many of the possible mediators of macrophage cell death。 ...
07-05-18摘要:NF-B Signaling PathwayThe transcriptional response in innate and adaptive immunity is dependent on the activation of various transcription factors。 Signaling to NF-kappaB。 Inhibition of Tumor Nec...
07-05-18摘要:Nitrite reduction to NO can occur via several routes involving enzymes, proteins, vitamins, or even simple protons。 Nitrite as a VasodilatorThe knowledge that inorganic nitrite can dilate vessels ...
07-05-18摘要:9 “Atherosclerosis-Specific“ Inflammatory PathwaysFrom the therapeutic standpoint, the challenge has been to identify an inflammatory pathway that is “atherosclerosis-specific,“ whereby therape...
07-05-18摘要:edu AbstractArterial stiffness is a growing epidemic associated with increased risk of cardiovascular events, dementia, and death。Arterial stiffness is an epidemic with increased risk。1–6 Arteri...
07-05-18摘要:vasculogenesis IntroductionFibroblast growth factors (FGF) constitute a family of at least 23 related heparin-binding growth factors with vital and broad functions in health and disease。 Fibroblas...
07-05-18摘要:Differential regulation of MAP kinases in SMC cell types。Constitutive Activation of the JAK/STAT Pathway in SOD2+/– SMCsExamination of MAP kinase activation provides a possible explanation for th...
07-05-18摘要:Surgical Off-Loading of Axial StrainAdult (body weight 3。 ResultsPartial Off-Loading of Axial Strain Induces Arterial TortuosityAxial strains of adult rabbit carotid arteries were off-loaded from ...
07-05-18摘要:Shear stress inhibited the SMC coculture-induced NF-B activation in ECs and monocytic THP-1 cell adhesion to ECs。 Shear stress inhibits these coculture-induced expressions。 Shear stress applied t...
07-05-18摘要:Shear stress elevated the c-Jun phosphorylation level in a time-dependent manner, similar to that of L-PGDS gene expression。Conclusions— Shear stress induces L-PGDS expression by transcriptional ...
07-05-18摘要:Sphingosine-1-phosphate (S1P) is a sphingolipid that binds to G protein-coupled receptors on endothelial cells (ECs)。Sphingosine-1-phosphate (S1P) is a biologically active sphingolipid in circulat...
07-05-18摘要:Cell death and apoptosis were determined after disruption of cadherins using several approaches (n3 per approach)。10 Cell–cell contacts can also inhibit apoptosis in some cell types11,12。Cell Cu...
07-05-18摘要:edu AbstractObjective— Free fatty acids (FFA) are commonly elevated in diabetes and obesity and have been shown to impair nitric oxide (NO) production by endothelial cells。Free fatty acids (FFA) ...
07-05-18摘要:From the Department of Medical Physiology (E。Q。, Y。R。, L。K。), Cardiovascular Research Institute, The Texas AM University System Health Science Center, College Station, Tex。 and Scott White ...
07-05-18摘要:be AbstractObjective— A potential role of growth arrest-specific gene 6 (Gas-6) in energy storage in adipose tissue was investigated in murine models of obesity。 Gas-6 is a ligand for the Axl, C-...
07-05-18摘要:1Connective tissue growth factor (CTGF), a potent angiogenic, chemotactic, and extracellular matrix–inducing growth factor, is produced by a wide variety of cells, including endothelial cells (ECs...
07-05-18摘要:Repopulation of apoE knockout mice with CCR2-deficient bone marrow progenitor cells demonstrates that hematopoietic CCR2 does not have a great effect on the progression of established atherosclerot...
07-05-18摘要:Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly。 Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine...
07-05-18摘要:nl AbstractObjective— Insulin resistance is associated with increased triglyceride levels, low high-density lipoprotein cholesterol, small dense low-density lipoprotein (LDL), and increased apolip...
07-05-18摘要:Methods and Results— Plasma levels of sRAGE were determined in 328 nondiabetic male patients with angiographically proved CAD and in 328 age-matched healthy controls。Soluble RAGE could prevent th...
07-05-18摘要:Serum uric acid values are associated with carotid plaque independently of other atherogenic risk factors in men without but not with metabolic syndrome or in women at all。 Between September 1994 ...
07-05-18摘要:es AbstractObjective— Nonalcoholic fatty liver disease (NAFLD) frequently coexists with obesity, diabetes, and dyslipidemia。 carotid ultrasound IntroductionNonalcoholic fatty liver disease (NAFLD...
07-05-18摘要:Measurement of CRP, Genotype, and Blood PressureCRP was assayed by a high-sensitivity immunonephelometric assay on a ProSpec protein analyzer (Dade-Behring) as described previously。 Blood samples ...
07-05-18摘要:ResultsEffects of Torcetrapib on HDL CompositionAs reported previously,16 CETP inhibition with torcetrapib significantly increased plasma concentrations of HDL-C and apoA-I in this study (Figure )。...
07-05-18摘要:Phosphatidylserine expression on monocytes is an important cofactor in the enzymatic reactions of coagulation。 Phosphatidylserine on the platelets was “cloaked“ by incubating the platelets with ...
07-05-18摘要:Platelet activation, which was increased in CHF, was reduced by treatment with rosuvastatin。16–18 Rosuvastatin increased vascular endothelial NO production and attenuated myocardial necrosis afte...
07-05-18摘要:Mevastatin attenuated IL-6–mediated increase of C/EBP protein in the nuclear extracts。 Mevastatin attenuated IL-6–mediated increase of C/EBP protein in the nuclear extracts。1 Plasminogen activa...
07-05-18摘要:Immune cells such as dendritic cells, mononuclear phagocytes, and T cells are present at the earliest stages of atherosclerosis, are key participants in all phases of development and destabilizatio...
07-05-18摘要:Surgical Professorial Unit, St Vincent’s Hospital, Sydney, AustraliaTo the Editor:Natural Killer T (NKT) cells comprise a heterogeneous subpopulation of T cells that coexpress T cell receptor (TCR...
07-05-18摘要:Departments of Nutritional Sciences, Laboratory Medicine, and Pathobiology, University of Toronto and Mount Sinai Hospital, Toronto, CanadaRobert ScraggSchool of Population Health, University of Au...
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