摘要：seThe innate immune defense is ready to combat invading microbes whenever they invade our inner territories。 Innate immunity consists of soluble molecules and cell-bound receptors, all of which ar...

摘要：inflammation •。 CD40 ligand •。 endothelial progenitor cellsAtherosclerosis is a chronic inflammatory process that affects arteries selectively and results from imbalance between injury ...

摘要：ukC-reactive protein (CRP) and cardiovascular disease is a very hot topic at present。1See page 1225Shortly after its discovery in 1929 as “the acute phase protein,“ increased production of CRP w...

摘要：In the Helsinki Heart Study (HHS), a 5-year, double-blind, placebo-controlled trial of the effects of gemfibrozil in 4081 men aged 40 to 55 years who were free of clinically manifest CHD at entry t...

摘要：From the Wallenberg Laboratory, University of G。teborg, Sahlgrenska University Hospital, G。teborg, Sweden。Correspondence to Sven-Olof Olofsson, Wallenberg Laboratory, University of G。

摘要：From the Atherosclerosis Research Unit, King Gustaf V Research Institute, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden。Correspondence to Profess...

摘要：From the Departments of Cardiovascular Medicine and Cell Biology and Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic Foundation, Cleveland, Ohio。 Hazen, MD, PhD, Cleveland C...

摘要：RaderNovel Approaches to the Treatment of DyslipidemiaATVB in FocusPrevious Brief Reviews in this Series:。 Much has been learned from mice with gene deletions for either ACAT1 or ACAT2。 Deletion ...

摘要：com AbstractExtracellular proteolysis plays a key role in many pathophysiologic processes including cancer, inflammatory diseases, and cardiovascular conditions such as atherosclerosis and restenos...

摘要：au AbstractAlthough vascular bypass grafting remains the mainstay for revascularization for ischemic heart disease and peripheral vascular disease, many patients do not have healthy vessels suitabl...

摘要：jp AbstractThe Krüppel-like factor (KLF) family is a recently highlighted group of zinc finger transcription factors given their important biological roles which include the vasculature。The Krüp...

摘要：Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase。 Reactive oxygen species mediate the activation of ...

摘要：edu AbstractObjective— Angiotensin II (Ang II) promotes vascular inflammation and remodeling via activation of nuclear factor B (NF-B)–mediated transcription of proinflammatory genes such as inte...

摘要：10 Cell adhesion to the ECM results in differentiation, proliferation, and suppression of apoptosis。 MethodsCell CultureHuman umbilical vein ECs (HUVECs。 Cells were plated on gelatin-coated plate...

摘要：Transcriptional regulation of inflammatory secreted phospholipases A2。 Transcriptional regulation of the rat type IIA phospholipase A2 gene by cAMP and interleukin-1beta in vascular smooth muscle ...

摘要：jp AbstractObjective— Vascular endothelial growth factor (VEGF) plays an important role in inducing angiogenesis。Vascular endothelial growth factor (VEGF) is a strong therapeutic reagent for trea...

摘要：de AbstractObjective— Endothelial dysfunction is an early event in the natural progression of heart failure。 A substudy of the Studies of Left Ventricular Dysfunction (SOLVD)。 Endothelial dysfun...

摘要：Activation of ABCA1 by oxysterols and retinoic acid was preserved in SW13 cells even in the absence of SWI/SNF chromatin remodeling activity (Figures 1, 3, and 4), a result observed previously in t...

摘要：Apolipoprotein A5 has recently been identified as a crucial determinant of plasma triglyceride levels。 ResultsROR1 and ROR4 Proteins Specifically Bind to a DR1 Site in the Human APOA5 Gene Promote...

摘要：Methods and Results— Fenofibric acid was examined for the effect of increase of ABCA1 activity。Conclusions— Fenofibric acid increased transcription of ABCA1 gene in a liver X receptor–dependent...

摘要：ResultsIncreased cholesterol deposition and lipid filled vesicles in Abca1-deficient macrophages。 Increased cholesterol deposition in Abca1-deficient macrophages incubated in the presence of eithe...

摘要：Oxidized LDLs induce EGFR activation and subsequent MMP-2 activation。1–3 Oxidized LDLs (oxLDLs) trigger cell signaling pathways involved in cellular responses, such as proliferation, inflammation...

摘要：Receptors involved in the Ox-PAPC-mediated synthesis of IL-8: A role for toll-like receptor 4 and a GPI anchored protein。

摘要：Adipocyte fatty acid–binding protein (aP2) is present in macrophages and has an important role in atherosclerotic plaque development。 Fatty acid regulation of gene expression。 Fatty acids are in...

摘要：C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for system...

摘要：Statins were obtained from a commercial source and dissolved in ethanol or H2O (ethanol 100% for atorvastatin, 10% for simvastatin and H2O for pravastatin)。 ResultsStatins Reduce IL-6–Induced CRP...

摘要：Serum CRP levels increased with age, were higher in women than in men, and were positively related to obesity and hyperglycemia。 Serum CRP 10 mg/L was associated with more extensive gross raised l...

摘要：Materials and MethodsTreatment of MiceLow-density lipoprotein receptor (LDLR)-deficient and CD40L-deficient mice (C57Bl/6) were obtained from Jackson Laboratories (Bar Harbor, Me)。 ResultsThe Deve...

摘要：se AbstractBackground— Immune responses against oxidized low-density lipoprotein (LDL) play an important role in atherosclerosis。Immune responses against oxidized low-density lipoprotein (LDL) ar...

摘要：be AbstractObjective— Apoptotic cell death has been demonstrated in advanced human atherosclerotic plaques。 Apoptotic cells (ACs) should be rapidly removed by macrophages, otherwise secondary nec...

摘要：Polymorphonuclear leukocytes (PMNs) are ubiquitous effector cells in numerous inflammatory conditions。Endothelium–Polymorphonuclear Leukocytes InteractionIn this study, we tried to link the forea...

摘要：Interleukin-18 (IL-18) is a pleiotropic proinflammatory cytokine with important regulatory functions in the innate immune response。 Spearman Rank Correlation of Metabolic Syndrome Traits and Infla...

摘要：Conclusion— High SFA caused deterioration in FMD compared with high PUFA, MUFA, or CARB diets。 Dietary Intake Estimated From 3-Day Food RecordsUltrasonographic AssessmentFlow-Mediated DilatationS...

摘要：se AbstractObjective— Gas6 is a member of the vitamin K-dependent protein family。 Gas6-deficient mice were found to be resistant to thrombosis because of defective platelet function。 Mouse Gas6 ...

摘要：Materials and Results— To search for these genes, we conducted a genome-wide scan using 21 Spanish families from the Genetic Analysis of Idiopathic Thrombophila (GAIT) Project。11 Recently, as par...

摘要：fr AbstractObjective— Platelet activation occurs in response to adhesion receptors for von Willebrand factor (GPIb-V-IX) and collagen (GPVI and 2。 platelet thrombosis IntroductionPhospholipase C ...

摘要：de AbstractBackground— Platelets play a key role in atherogenesis and thromboembolic complications in patients with type 2 diabetes。 Platelet activation was assessed with the use of immunologic m...

摘要：ReferencesNational Cholesterol Education Program。 Report of the Expert Panel on Population Strategies for Blood Cholesterol Reduction: executive summary。Executive Summary of The Third Report of T...

摘要：Complex stenoses are at a higher risk of rapid progression than smooth lesions,2 and we have recently shown that markers of both inflammation and macrophage activation predict rapid coronary artery...