摘要:Methods and Results- A variety of enzyme-linked immunosorbent assays (ELISAs) were evaluated for their preferential reactivity toward TAFI before and after activation, and toward the recombinantly ...
08-12-28摘要:Insulin inhibits Ca 2+ mobilization in platelets by interfering with P2y 12 -mediated cAMP suppression。 【关键词】 Py receptor Ca + regulation clopidogrel protein kinase B/Akt IRS Int...
08-12-28摘要:【摘要】 Objective- To examine the association of socioeconomic factors with progression of carotid intimal-medial thickness (IMT) in middle-aged adults。 It is unclear whether these factors a...
08-12-28摘要:【摘要】 Background- Both the metabolic syndrome and an increased apolipoprotein B/AI (apoB/AI) ratio are powerful risk factors for cardiovascular events。 We hypothesized that the apoB/AI rat...
08-12-28摘要:Elevated levels of sICAM-1 were also associated with an increased risk of type 2 diabetes。 【关键词】 endothelial dysfunction type diabetes adhesion molecules von Willebrand factor In...
08-12-28摘要:11 Genes implicated in rare Mendelian forms of HDL deficiency include apolipoprotein A-I and lecithin cholesterol acyltransferase。Materials and MethodsSubjectsA total of 13 multigenerational Frenc...
08-12-28摘要:Hormonal replacement therapy (HRT) affects plasma HDL cholesterol levels, with estrogen increasing HDL cholesterol levels and progestins blunting this effect。Materials and Methods- HDL apolipoprot...
08-12-28摘要:MethodsStudy PopulationPatients in the present study participated in the QUinapril On Vascular Ace and Determinants of Ischemia Study (QUO VADIS)。 The glomerular filtration rate (GFR) was estimate...
08-12-28摘要:ResultsCholesterol Loading by Ac-LDL and ACAT Inhibitor Induces Membrane Ruffles and Stimulates Cell SpreadingTo load cell membranes with cholesterol, we treated J774 macrophages with 50 µ。In...
08-12-28摘要:Arginase I was identified as a new candidate gene of atherosclerosis resistance using suppression subtractive hybridization in macrophages of rabbits with low and high atherosclerotic response。 Se...
08-12-28摘要:【摘要】 Objective- Apolipoprotein E (apoE) and apolipoprotein B100 (apoB) are both involved in receptor-mediated uptake of atherogenic lipoproteins by the liver。Conclusions- Increased apolip...
08-12-28摘要:Cells expressing TK can metabolize the nucleoside analog ganciclovir (GCV) into toxic triphosphated GCV that, by blocking DNA elongation, kills dividing cells。 Cells were analyzed with a FACSCalib...
08-12-28摘要:Atherosclerotic Lesions, VV Neovascularization, and InflammationMicro-CT analysis data are presented in Table。 Vasa vasorum in atherosclerotic coronary arteries: responses to vasoactive stimuli an...
08-12-28摘要:【摘要】 Background- Matrix metalloproteinase-9 (MMP-9) is involved in atherosclerosis and elevated MMP-9 activity has been found in unstable plaques, suggesting a crucial role in plaque ruptu...
08-12-28摘要:Methods and Results- We examined basal and NAD(P)H oxidase-mediated superoxide (O 2 ·。 NAD(P)H oxidase subunits and xanthine oxidase expression were measured。 Superoxide production was grea...
08-12-28摘要:Conclusions- Medial atrophy is prevalent in restenotic lesions and stable plaques compared with mildly stenotic plaques and erosions。 Intimal SMCs of all situations exhibit a phenotypic profile, s...
08-12-28摘要:Expression profiles of whole plaque and plaque subcomponents (media。 Expression in the fibrous cap was contrasted with expression in normal carotid media, adjacent nonatherosclerotic intima, and t...
08-12-28摘要:The objective of this study was to determine the relative contributions of blood cell-associated versus endothelium-associated AT1a-R to these hypercholesterolemia-induced microvascular alterations...
08-12-28摘要:3-5 Conjugated linoleic acid (CLA) is a naturally occurring fatty acid and is found in dairy products and meat from ruminants。 Conjugated Linoleic Acids (CLA): Are they Ambrosia or Merely a Panace...
08-12-28摘要:Conclusions- Hepatic PON1 and CYP7A1 mRNA expression is repressed by bile acids via FXR-mediated induction of FGF15。ResultsTLR4 Function Is Not Involved in the Resistance of C3H/HeJ Mice to Diet-I...
08-12-28摘要:Interleukin-18/interleukin-18 binding protein signaling modulates atherosclerotic lesion development and stability。 Interleukin-18 enhances atherosclerosis in apolipoprotein E(-/-) mice through re...
08-12-28摘要:【摘要】 Objective- Endothelial dysfunction and vascular dysregulation contribute to the pathological effects of radiation on tissues。Conclusions- Radiation induces acute microvascular dysfun...
08-12-28摘要:Arterial SP Cell Phenotyping for Stem/Progenitor MarkersTo further characterize arterial SP and MP cells, expression levels of stem or progenitor cell markers were evaluated at their surface by flo...
08-12-28摘要:【摘要】 Objective- Tumor necrosis factor- (TNF- ) has been linked to obesity-related insulin resistance and impaired endothelium-dependent vasodilatation, but the mechanisms have not been elu...
08-12-28摘要:Endothelial Protection and Permissive SignalingNO is a reactive molecule that can rapidly diffuse throughout the cell。 Right, Endothelial activation。 Nitric oxide control of the dorsal aorta and ...
08-12-28摘要:Atherogenesis: The Pivotal Influence of Risk Factors on the EndotheliumDespite intense research efforts, the underlying molecular mechanisms of atherosclerosis are still incompletely understood。EP...
08-12-28摘要:【摘要】 Smoking causes up to 11% of total global cardiovascular deaths。 Smoking has numerous effects that may promote atherosclerosis through vascular inflammation and oxidative stress, but ...
08-12-28摘要:【摘要】 Lipid-enriched diets are often used to induce or accelerate the rate of atherosclerotic lesion development in murine models of atherosclerosis。 It appears that the induction of persi...
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