摘要：【摘要】 Objectives- Thrombin interacts with platelets via the protease-activated receptors (PARs) 1 and 4, and via glycoprotein Ib (GPIb )。 Recently, it was shown that platelets are able to ...

摘要：ResultsTranslocating Platelets Undergo a Distinct Series of Morphological Changes in Response to Increased Wall Shear StressTo investigate the effects of shear on platelet morphology during surface...

摘要：Carotid IMT and CRP performed poorly compared with CPA and CCS。Carotid plaque area was more sensitive, specific, and had a higher negative predictive value than coronary calcium, C-reactive protei...

摘要：【摘要】 Objective- The relationship between Chlamydia pneumoniae ( Cpn ) infection and arterial measures of preclinical atherosclerosis has remained controversial。 Because atherogenesis begi...

摘要：【摘要】 Background- Lipoprotein lipase (LPL) is associated with coronary artery disease (CAD) risk, but prospective population data are lacking。 Serum LPL concentration was lower in cases co...

摘要：Occupational StatusInformation about occupation was retrieved by data linkage with the national census investigations performed in 1970, 1980, and 1985, which are total registers of the Swedish pop...

摘要：Measures of AtherosclerosisUltrasonography of both carotid arteries was performed with a 7。

摘要：Rosiglitazone had direct effects on inflammatory markers and adipokines in the absence of favorable lipid effects。 Rosiglitazone raises HDL-C levels from 3% to 13。 Rosiglitazone has been shown to...

摘要：Methods and Results- Circulating CD4 + /CD31 + cells were reduced in AAA patients (n=80, 8。 Exclusion of the aneurysm by an endoprothesis did not affect CD31 + T cell values。 Reduction of blood C...

摘要：【摘要】 Objective- Metformin may benefit the macrovascular complications of diabetes independently of its conventional hypoglycemic effects。Methods and Results- Metformin dose-dependently in...

摘要：Methods and Results- Pravastatin downregulated LOX-1 expression in cultured human M s and in cultured human aortic SMCs。 Pravastatin was kindly provided by Bristol-Myers Squibb, TNF- was purchased...

摘要：Conclusions- Loci were identified for atherosclerosis susceptibility in a strain intercross study。 Atherosclerosis QTLsFigure 2。

摘要：Results18 F-FCH Macroscopically Visualizes Murine Atherosclerotic PlaquesEn face analysis of atherosclerotic plaques revealed a strong and selective uptake of 18 F-FCH ( Figure 1 A)。18 F-FDG Visua...

摘要：【摘要】 Objective- We investigated the associations between plasma very-low-density lipoprotein (VLDL)-apolipoprotein (apo)C-III and apoA-V concentrations and the kinetics of VLDL-apoB-100 an...

摘要：【摘要】 Objective- Immune complexes containing oxidatively modified low-density lipoprotein (oxLDL) particles are deposited in human atherosclerotic lesions during atherogenesis。 Here we stu...

摘要：Ultrastructure of Aortic Media in 5/6 Nephrectomized Mice With Advanced AtherosclerosisTo further evaluate the structural characteristics of the media in NX apoE -/- mice, we examined proximal aort...

摘要：【摘要】 Objective- Transglutaminase 2 (TG2), a broadly expressed regulator of protein cross-linking, wound healing, and tissue fibrosis, mediates apoptotic cell ingestion and transforming gro...

摘要：Atherosclerosis could not be analyzed in apoE -/- mice expressing low levels of TF because of premature death of these mice。 Atherosclerosis within the arterial tree and aortic root were similar i...

摘要：Hepatic lipase (HL) hydrolyzes triglycerides and phospholipids and is involved in processing chylomicron remnants, intermediate-density lipoprotein and HDL。Effects of Hepatic Lipase Deficiency on ...

摘要：【摘要】 Objectives- Cholesterol efflux is achieved by several mechanisms。 This study examines contributions of these pathways to efflux to human serum。Methods and Results- Human fibroblasts...

摘要：【摘要】 Objective- To study the acceptor specificity for human ABCG1 (hABCG1)-mediated cholesterol efflux。Methods and Results- Cells overexpressing hABCG1 were created in Chinese Hamster Ova...

摘要：Identification of cAMP-Responsive Regions in the ABCA1 GeneTo identify cAMP response elements (CRE) in the mouse ABCA1 gene, a bioinformatics approach was tried but was not successful (data not sho...

摘要：LDI and Reactive HyperemiaMouse feet were scanned with a laser Doppler imager (MLDI 5063。 1Differences in preexistent collateral vasculature can strongly impact the milieu for growing collaterals ...

摘要：1-4 Elevated plasma levels of nonesterified fatty acids (NEFA) are commonly present in individuals with insulin resistance or type 2 diabetes, and it has been suggested that these chronically eleva...

摘要：ResultsTime- and Dose-Dependent Increase in Monocyte Adhesion to Hcy-Incubated ECsIncubation of EA。Stereospecific Effect of L-Hcy on Monocyte Adhesion to ECsTo examine whether the effect of Hcy is...

摘要：Protein tyrosine phosphatases (PTPs) are thought to play an important role as counter-regulatory agents that attenuate or terminate signaling induced by activation of receptor tyrosine kinases。 Pr...

摘要：Enzymatic Scavengers of ROS Inhibit lysoPC EffectsTo confirm the role of ROS in the regulation of proteoglycan synthesis, several compounds were tested for their ability to modulate the lysoPC resp...

摘要：6-8Thromboxane A 2 (TXA 2 ) is an unstable metabolite of arachidonic acid formed through the cyclooxygenase pathway。 Thromboxane A2 signalling in humans: a 。 Thromboxane A2 receptor agonists anta...

摘要：【摘要】 Objective- Brain expresses abundant lipocalin-type prostaglandin (PG) D 2 (PGD 2 ) synthase but the role of PGD 2 and its metabolite, 15-deoxy- 12,14 PGJ 2 (15d-PGJ 2 ) in brain prote...

摘要：Because tumor necrosis factor- (TNF- ) is reportedly expressed during ischemia and can induce vascular inflammation leading to endothelial dysfunction, we hypothesized that this inflammatory cytoki...

摘要：3Endothelial cells (ECs) in the adult maintain their asymmetrical arteriovenous expression of ephrinB2 and EphB4, 9,10 suggesting that the EphB/ephrinB system may play a role in controlling vascula...

摘要：Materials and MethodsEC Isolation and CultureHuman saphenous veins ECs (HSVECs) and foreskin microvascular endothelial cells were prepared and cultured as described。ResultsComparison of Efficiency...

摘要：【摘要】 Tissue factor (TF) encryption is the post-translational suppression of TF procoagulant activity (PCA) on the cell surface。 There is emerging evidence of encrypted TF in normal blood ...

摘要：【摘要】 The cAMP response element binding protein (CREB) is a ubiquitously expressed nuclear transcription factor that is activated by various extracellular stimuli。The cAMP response element...

摘要：【摘要】 After receptor-mediated endocytosis, the intracellular fate of triglyceride-rich lipoproteins (TRLs) is far more complex than the classical degradation pathway of low-density lipoprot...

摘要：6,8 Nanotechnology seeks to develop and combine new materials by precisely engineering atoms and molecules to yield new molecular assemblies on the scale of individual cells, organelles, or even sm...