摘要:Inflammation in atherosclerosis。 Immune mechanisms in atherosclerosis。 Immune modulation of metalloproteinase production in human macrophages。
08-12-28摘要:Dietary Fatty Acids and Biomarkers of InflammationTable 2 summarizes the role of dietary fatty acids in modulating biomarkers of inflammation in human subjects。 Summary of Randomized Clinical Tria...
08-12-28摘要:PPAR- : A Regulator of the Inflammatory ResponseAtherosclerosis is considered as an inflammatory disease。Cellular and Molecular Mechanisms of the Hepatic Antiinflammatory Action of PPAR-Several st...
08-12-28摘要:【摘要】 Obesity is becoming a global epidemic in both children and adults, and it is associated with numerous co-morbidities such as cardiovascular diseases (CVD), type 2 diabetes, hypertensi...
08-12-28摘要:KLF2 Inhibits NF- B Activation by ThrombinThrombin-mediated activation of NF- B is an important mechanism underlying its proinflammatory effects。KLF2 Inhibits Thrombin-Induced Proinflammation Thro...
08-12-28摘要:-specific agonist Am80, which is also an IL-6 inhibitor, can modulate macrophage lipid accumulation and foam cell formation。Methods and Results- Am80 suppressed IL-6 production induced by 12-myris...
08-12-28摘要:An excessive accumulation of extensively oxidized low-density lipoprotein (OxLDL) or free cholesterol (FC), both of which are believed to be major lipid components of macrophages in advanced lesion...
08-12-28摘要:7,8 Angiotensin II (Ang II), which participates in atherogenesis, 9 also upregulates the expression of LOX-1。 Angiotensin II is associated with activation of NF-kappaB-mediated genes and downregul...
08-12-28摘要:Preparation of LipoproteinPlasma was collected from healthy human volunteers and LDL was isolated by sequential ultracentrifugation as described in our previous publication。 Dysregulation of LDL r...
08-12-28摘要:Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure。 Advanced oxidation protein products as risk factors for atherosclerotic car...
08-12-28摘要:【摘要】 Objective- We quantified endothelial progenitor cell (EPC) engraftment into the endothelial layer as an index of progenitor-mediated endothelial repair。 Studies were conducted in C57...
08-12-28摘要:Celecoxib also decreased the incidence and severity of AAAs in nonhyperlipidemic mice。ResultsSelective COX-1 Inhibition Does Not Alter the Incidence or Severity of Ang II-Induced AAAs in ApoE-/- M...
08-12-28摘要:Small Animal NIR Fluorescence Imaging SystemDetails of the small animal NIR fluorescence imaging system have been described in detail。 14In Vivo ImagingThe lateral tail vein was injected with 0。T...
08-12-28摘要:【摘要】 Background- We aimed to establish a completely noninvasive technique to assess coronary artery atherosclerosis in living mice using proximal to middle left coronary artery (LCA) veloc...
08-12-28摘要:【摘要】 Objective- Although it has been reported that matrix metalloproteinase (MMP)-2 is a major proteinase in atherosclerotic plaque lesions, there is no direct evidence of the role of MMP-...
08-12-28摘要:【摘要】 Objective- Transforming growth factor (TGF)-ß。1 (TGF-ß。 Production and plasma levels of TGF-ß。1 are influenced by polymorphisms in the TGF-ß。
08-12-28摘要:Age-adjusted and gender-adjusted IMT increased with increasing low-density lipoprotein (LDL) cholesterol and decreased with increasing high-density lipoprotein (HDL) cholesterol。 By multivariate a...
08-12-28摘要:Methods and Results- Kinetics of triglyceride-rich lipoprotein (TRL) apoB-48 and very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and low-density lipoprotein (LDL) apoB-...
08-12-28摘要:【摘要】 Objective- The proprotein convertase subtilisin/kexin type 9 (PCSK9) gene encodes a proprotein convertase that causes degradation of cell surface low-density lipoprotein receptors (LD...
08-12-28摘要:Endothelial dysfunction and low-grade inflammation may explain, at least in part, the increased cardiovascular disease risk in type 2 diabetes (T2D)。 17Markers of Endothelial Dysfunction and Low-G...
08-12-28摘要:Arteries did calcify during incubation in rat, bovine, and human serum, and additional experiments were accordingly performed to compare the biochemical characteristics of the serum calcification f...
08-12-28摘要:4,19 Early LECs start to bud from the anterior cardinal vein at E10。ResultsFormation of Lymphatic Structures in Response to VEGF-C and VEGF-AWe recently showed that embryoid bodies placed in 3-dim...
08-12-28摘要:Adhesion Studies In VitroCultured EPCs, fibroblasts (negative control) and Jurkat, and leukemic T-lymphocytes (positive control) were labeled with DiI, and then 10 5 cells per well were incubated o...
08-12-28摘要:OxLDL and PDGF Modulate Genes and Molecular Pathways Involved in Atherosclerosis in SMCsSeveral families of genes that may be associated with atherosclerosis were also differentially regulated by O...
08-12-28摘要:Vasohibin-2 exhibited antiangiogenic activity。 Vasohibin-2 expression in cultured endothelial cells was low and not inducible by the stimulation that induced vasohibin-1。 Vasohibin-2 exhibited an...
08-12-28摘要:One of the transcription factors activated in the liver during hyperhomocysteinemia was cAMP-response element binding protein (CREB)。 CREB regulates the expression of many genes including those in...
08-12-28摘要:【摘要】 Objective- Expression of endothelial nitric oxide synthase (eNOS) is a critical determinant for vascular homeostasis。 We examined the effects of Beraprost sodium (BPS), a stable anal...
08-12-28摘要:【摘要】 Background- CD4-positive lymphocytes, the major T-cell population in human atheroma, mainly secrete Th-1-type proinflammatory cytokines, like interferon (IFN), tumor necrosis factor (...
08-12-28摘要:Discovery of Putative Circulating EPCsThe integrity of the endothelial lining of the vasculature is essential for vascular homeostasis and normal organ function。EPC Insufficiency as a Possible Cau...
08-12-28摘要:Reconstitution of these eNOS knockdown ECs with Golgi- and PM-targeted eNOS restored the ability of ECs to produce NO。To determine the functional significance of subcellular targeting in endotheli...
08-12-28摘要:【摘要】 Agonist-induced release of endothelial cell specific storage granules, designated Weibel-Palade bodies (WPBs), provides the endothelium with the ability to rapidly respond to changes ...
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