摘要:Genetic susceptibility to death from coronary heart disease in a study of twins。 Genetic variation at the human tissue-type plasminogen activator (tPA) locus: haplotypes and analysis of associatio...
08-12-28摘要:【摘要】 Objective- Homocysteine (Hcy) is a risk factor for thrombosis。 Fibrin clots composed of dense fiber networks have been found in survivors of myocardial infarction 50 years of age and...
08-12-28摘要:【摘要】 Objective- Plasma fibronectin (FN) is decreased in several clinical conditions。ResultsPlasma and Platelet FN, Whole Blood Clotting, and Bleeding Time in FN +/- MicepFN is an importan...
08-12-28摘要:【摘要】 Objective- Collateral artery development (arteriogenesis), a vital compensatory mechanism in patients with arterial obstructive disease, may be deregulated by vascular risk factors, e...
08-12-28摘要:【摘要】 Objective- Subjects with family history for coronary heart disease (CHD) may be more susceptible to the adverse effects of risk factors than subjects without family history。 We inves...
08-12-28摘要:【摘要】 Objectives- Lecithin:cholesterol acyltransferase deficiency (LCAT-def) is characterized by low levels of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) and the accum...
08-12-28摘要:【关键词】 adiponectin apoAI HDL cholesterol insulinresistance kinetic IntroductionAdiponectin is a peptide predominantly synthesized in the adipose tissue that plays an important role in carboh...
08-12-28摘要:Sample Processing, Laboratory Measurements, Analysis of Lipoprotein Production and Clearance Rates, and Statistical AnalysisPlease see the online data supplement, available at http://atvb。Effects ...
08-12-28摘要:【摘要】 Objective- Cholesteryl ester transfer protein (CETP) inhibition with torcetrapib not only increases high-density lipoprotein cholesterol levels but also significantly reduces plasma t...
08-12-28摘要:Exposure of HUVECs to pathophysiologic LDL concentrations has been shown to cause increased expression of ICAM-1 and VCAM-1 on the cell surface。Materials and MethodsLDL, High-Density Lipoprotein, ...
08-12-28摘要:【摘要】 Objective- Because culprit atherosclerotic plaques contain proteases, we hypothesized that the diminished heat shock protein 27 (HSP27) released by atherosclerotic plaques could be du...
08-12-28摘要:【摘要】 Objective- The cytokine transforming growth factor-ß。 (TGF-ß。 Despite such importance, the mechanisms underlying the regulation of apoE expression by TGF-ß。Methods a...
08-12-28摘要:Methods and Results- One hundred fifty patients referring to vascular diagnostic centers for suspected carotid atherosclerosis (at ultrasound examination: 110 positive, 40 negative) and controls (n...
08-12-28摘要:Replacement of the Di-Leucine Motif Alters DiI-AcLDL Uptake by CHO Cells Expressing SR-AIncubation with DiI-AcLDL (5 µ。Di-Leucine Motif-Mediated Endocytosis Is Not Associated With Clathrin-Co...
08-12-28摘要:【摘要】 Objectives- This study examines the ABCG1-mediated cholesterol efflux and intracellular cholesterol transport by studying the ABCG1 localization and function in macrophages。Methods a...
08-12-28摘要:Methods and Results- The left common carotid arteries of male apolipoprotein E (apoE)-deficient mice (9 weeks old) were ligated just proximal to their bifurcations。Materials and MethodsMiceThe mal...
08-12-28摘要:【摘要】 Objective- Perivascular adipose tissue of normotensive rats releases a transferable factor that induces relaxation by opening voltage-dependent K + (K v ) channels。 Mesenteric bed (M...
08-12-28摘要:【摘要】 Objective- The extracellular N terminus of the endothelin B (ET B ) receptor is cleaved by a metalloprotease in an agonist-dependent manner, but the physiological role of this N-termi...
08-12-28摘要:【摘要】 Objective- Pleiotrophin (PTN) is a cytokine that is expressed by monocytes/macrophages in ischemic tissues and that promotes neovascularization, presumably by stimulating proliferatio...
08-12-28摘要:Kinase Activity AssaysThe kinase activities of LKB1 and AMPK were assayed as described。
08-12-28摘要:Apelin-induced phosphorylation of MLC was accompanied with myosin phosphatase target subunit phosphorylation。 【关键词】 apelin APJ myosin light chain myosin phosphatase target subunit v...
08-12-28摘要:In the current study, we identified mechanisms through which 12/15LO mediates monocyte:endothelial interactions in vivo in apolipoprotein E-deficient mice (apoEKO), a well-characterized mouse model...
08-12-28摘要:Plasminogen activator inhibitor-1 and its cofactor vitronectin stabilize arterial thrombi after vascular injury in mice。 Plasminogen activator inhibitor type 1 increases neointima formation in bal...
08-12-28摘要:21Modulation of the LR11/uPAR Pathway for Prevention of AtherosclerosisStatins are potent inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase that are known to be effective for preven...
08-12-28摘要:【摘要】 Lipoprotein lipase (LPL) hydrolyzes triglycerides in the circulation and promotes the hepatic uptake of remnant lipoproteins。 Since the gene was cloned in 1989, more than 100 LPL gen...
08-12-28摘要:Approaches for Gene Expression Profiling of Atherosclerosis Using Vascular SamplesIn gene expression profiling studies in atherosclerosis, transcript levels have been determined in human as well as...
08-12-28摘要:【摘要】 The endothelium controls vascular tone not only by releasing nitric oxide (NO) and prostacyclin but also by other pathways causing hyperpolarization of the underlying smooth muscle ce...
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