摘要：【摘要】 Objective- We investigated whether dietary factors explain higher plasma fibrinogen levels in Japanese emigrants living a Western lifestyle in Hawaii compared with Japanese in Japan。...

摘要：【摘要】 Objectives- Current evidence suggests the CD40-CD40L pathway as a key process in the development, progression, and outcome of acute coronary syndrome (ACS)。 The aim was to investigat...

摘要：Effects in the intranasal group were smaller than in the oral group, which may suggest a lower venous thrombosis risk。 Intranasal indicates spray containing 175 µ。 Intranasal indicates spray...

摘要：orgResultsIn a Model of Activated EC, CD34 + Use Thrombi to Escape From FlowFirst, we studied mild EC injury, such as hypoxia, in which ECs are activated but not apoptotic。In a Model of Vascular D...

摘要：Conclusions- Clopidogrel improves endothelial nitric oxide bioavailability and diminishes biomarkers of oxidant stress and inflammation in patients with symptomatic coronary artery disease, suggest...

摘要：19ResultsReduced Thrombin Response After Anti-GPVI Treatment With JAQ1In previous studies, mice treated with a 100 µ。 a, After antibody treatment, platelet counts were monitored over 5 days。...

摘要：Local heat shock priming (42。Conclusions- Heat shock induces endogenous hyperfibrinolysis by upregulation of plasminogen activators that promote recanalization of thromboembolized microvasculature...

摘要：【摘要】 Objective- After activation, platelets expose CD40 ligand (CD40L) on their surface, then subsequently release the inflammatory mediator as a soluble fragment (sCD40L)。 Because sickle...

摘要：23 A large sample of 835 subjects (Saguenay-Lac St Jean cohort) of French Canadian descent from Saguenay-Lac St Jean area in the Province of Quebec was also selected。Detection of the VariantGenoty...

摘要：We found that a VAMP8 variant ( P =0。62) and an HNRPUL1 variant ( P =0。Conclusions- Variants in 2 genes were associated with early-onset MI: VAMP8, which is involved in platelet degranulation, an...

摘要：Clinical Characteristics by Sex and Presence (ATS+) or Absence (ATS-) of Coronary AtherosclerosisAmong men, 24% were nondrinkers as compared with 59% of women ( P 0。 Alcohol consumption was associ...

摘要：Histological Image AnalysisDetermination of USPIO Accumulation Within PlaquesPerls reagent uptake was used as a surrogate marker for the presence of USPIO。 North American Symptomatic Carotid Endar...

摘要：Fluorescence analysis of biochemical constituents identifies atherosclerotic plaque with thin fibrous cap。 Fluorescence, reflectance, and light-scattering spectroscopy for evaluating dysplasia in ...

摘要：【摘要】 Objective- To study the distribution of group V secretory phospholipase A 2 (sPLA 2 ) in human and mouse lesions and compare its expression by human vascular cells, its activity towar...

摘要：【摘要】 Objectives- We sought to evaluate whether lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ), an emerging marker of cardiovascular risk, is associated with prognosis in patients wit...

摘要：【摘要】 Objective- Using bone marrow transplantation, we assessed the impact of macrophage-derived phospholipid transfer protein (PLTP) on lesion development in hypercholesterolemic mice that...

摘要：【摘要】 Objective- We investigated the role of adipocyte differentiation-related protein (ADRP) in triglyceride turnover and in the secretion of very low-density lipoprotein (VLDL) from McA-R...

摘要：【摘要】 Background- Oxidized low-density lipoprotein (LDL) is associated with cardiovascular disease。 We searched for the strongest gene correlates of oxLDL in macrophages in coronary plaque...

摘要：【摘要】 Objective- Antimicrobial peptides are effector molecules of the innate immune system。 To understand the function of vascular innate immunity in atherosclerosis, we investigated the r...

摘要：3,4Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme that, among many other functions, metabolizes pro-inflammatory lipids formed during the oxidation of low-density lipopr...

摘要：【关键词】 nitric oxide nitric oxide synthase arteriosclerosis blood pressure gene expression IntroductionNeuronal nitric oxide synthase (nNOS) is expressed in early and advanced human atheroscl...

摘要：Methods and Results- Synthetic peptide VIVIT potently inhibited NFAT activation in RAW 264。Synthetic peptide inhibitor of NFAT selectively and potently inhibits NFAT activation and vSMC proliferat...

摘要：17ß。-estradiol (E2) plays an important role in this process because it can attenuate pressure overload hypertrophy via 2 distinct estrogen receptors (ERs): ER and ERß。 We therefore used...

摘要：Systemic Hemodynamics in WT and eNOS Transgenic MiceCardiomyocyte-Specific Overexpression of eNOS Significantly Reduces MI-R InjuryWT, SYS eNOS-Tg, and CS eNOS-Tg mice were first subjected to 30 mi...

摘要：Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly。 Matrix metalloproteinase-9 overexpression enhances vascular smooth muscle cell migration and al...

摘要：signaling arterial remodeling IntroductionTransforming growth factor ß。 2Matrix proteins like collagen and FN also sequester oxidized low-density lipoprotein, immunoglobulins, and growth f...

摘要：Functional Role of TRPV4 in Endothelium-Dependent VasodilatationTo understand the functional role of TRPV4 in the mechanism of endothelium-dependent vasodilatation of CAs and small more resistance-...

摘要：Methods and Results- Although the transfection of expression vectors for 2 isoforms of DDAH, DDAH1, or DDAH2 increased DDAH activity in bovine aortic endothelial cells and human umbilical vein endo...

摘要：Peroxisome proliferator-activated receptor activation promotes cell survival following hypertonic stress。 Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR...

摘要：Rapamycin potently activates AKT-dependent signaling, an effect that causes phosphorylation of FOXO1。 3,4,7,8Paclitaxel, semisynthetic diterpenoid, binds the ß。 Paclitaxel also has a wide ra...

摘要：Angiopoietin-1 (Ang-1) is requisite for vascular maturation during angiogenesis。 14,15Angiopoietin-1 (Ang-1) has been identified as a ligand for a receptor tyrosine kinase Tie-2 expressed on endot...

摘要：Smooth muscle cells (SMCs) are defined by their expression of SMC-specific isoforms of contractile proteins。Vascular Differentiation of ES CellsTo induce differentiation, ES cells growing on MEF c...

摘要：【摘要】 Cardiac allograft vasculopathy (CAV) is a form of coronary arterial stenosis and a leading cause of death in patients who survive beyond the first year after heart transplantation。Ca...

摘要：【摘要】 Nitric oxide (NO) is a multifunctional biomolecule involved in a variety of physiological and pathological processes, including regulation of blood vessel dilatation and anti-arterios...

摘要：【关键词】 adhesion endothelial cells junction proteins IntroductionEndothelial cells are maintained in contact to one another by a complex network of transmembrane adhesion proteins anchored to...

摘要：【摘要】 Vascular calcification increasingly afflicts our aging and dysmetabolic population。 Vascular expression of pro-osteogenic morphogens is entrained to physiological stimuli that promot...