摘要:【摘要】 Objective- 3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) exhibit antithrombotic properties that are independent of reductions in circulating LDL chole...
08-12-28摘要:【摘要】 Objective- Recombinant factor VIIa (rFVIIa, NovoSeven) has proven efficacy in treating bleeding in hemophilia patients with inhibitors。 A rFVIIa analog with mutations V158D/E296V/M29...
08-12-28摘要:17Loss of Function Mutation Ala68fsLeu82X in PopulationOn the assumption that the Ala68fsLeu82X in PCSK9 was indeed the cause of low LDL-C, we addressed the question whether this mutation was also ...
08-12-28摘要:Intima thickness, IMT, and IT-to-lumen diameter ratio demonstrated univariate associations ( P 0。 Intimal plus medial thickness of the arterial wall: a direct measurement with ultrsound imaging。
08-12-28摘要:【摘要】 Background- Apolipoprotein B (apoB) levels predict fatal myocardial infarction。 Whether apoB also predicts nonfatal ischemic cardiovascular events is unclear。 We tested the followin...
08-12-28摘要:9,10 See page 439Osteopontin (OPN, SPP1, OMIM*166490) is a phosphorylated acidic glycoprotein that has been implicated in a large number of physiological and pathological processes including bone r...
08-12-28摘要:Prevalence of extracranial carotid artery disease detectable by echo-Doppler in an elderly population。 Prevalence of asymptomatic carotid disease: results of duplex scanning in 348 unselected volu...
08-12-28摘要:【摘要】 Background- Aortic valve calcification (AVC) is considered degenerative。Methods and Results- AVC and coronary artery calcifications (CAC) were prospectively assessed by Electron-Beam...
08-12-28摘要:Peroxisome proliferator-activated receptor ligand bezafibrate for prevention of type 2 diabetes mellitus in patients with coronary artery disease。 Effects of long-term fenofibrate therapy on cardi...
08-12-28摘要:In HepG2 cells TSA activated all peroxisome proliferator-activated receptors (PPARs) in a dose-dependent manner。Conclusions- Our data suggest that TSA exert potent antioxidant, antiinflammatory, a...
08-12-28摘要:Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes。 Granulocyte/macrophage colony-stimu...
08-12-28摘要:3 Chemokines are such molecules, being a family of cytokines characterized by their ability to cause directed migration of leukocytes into inflamed tissue。ResultsThe Expression of CCR7 and its Cor...
08-12-28摘要:【摘要】 Objective- The sphingosine-1-phosphate (S1P) analogue FTY720 is a potent immunosuppressive agent currently in Phase III clinical trials for kidney transplantation。 FTY720 traps lymph...
08-12-28摘要:【摘要】 Objective- Group V secretory phospholipase A 2 (GV sPLA 2 ) has been detected in both human and mouse atherosclerotic lesions。 【关键词】 Group V secretory phospholipase A ...
08-12-28摘要:【摘要】 Objective- ABCG1 has recently been identified as a facilitator of cholesterol and phospholipid efflux from macrophages to HDL。 In bone marrow transplantation studies, we and others h...
08-12-28摘要:The phagocytic NADPH oxidase has been also associated with atherosclerosis。 This study aimed to investigate the association between phagocytic NADPH oxidase and MMP-9 in human atherosclerosis。Met...
08-12-28摘要:【摘要】 Objective- Systemic phospholipid transfer protein (PLTP) deficiency in mice is associated with a decreased susceptibility to atherosclerosis, whereas overexpression of human PLTP in m...
08-12-28摘要:Genes Upregulated in Foam Cell MacrophagesDownregulated GenesOf 23 genes we tested from the reverse subtraction, we found 11 significantly downregulated by semi-quantitative PCR ( Table 2 ), a rate...
08-12-28摘要:Angiopoietins 1, 2, 3, and 4 elicited different amounts of blood and lymphatic vascular remodeling in normal and wound healing tissues。MethodsGeneration of Adenoviral AngiopoietinsRecombinant aden...
08-12-28摘要:5 mg/kg/d), (4) pravastatin (100 mg/kg/d), and (5) combined olmesartan and pravastatin for 4 weeks。 Olmesartan or pravastatin significantly and comparably improved vascular endothelium-dependent r...
08-12-28摘要:7,8 Basic fibroblast growth factor (bFGF) is known to be a potent angiogenic factor, and has also been identified as a survival factor (anti-apoptotic factor) for endothelial cells (ECs) and SMCs o...
08-12-28摘要:【摘要】 Objective- Stem cell factor (SCF) through its cognate receptor, the tyrosine kinase c-kit, promotes survival and biological functions of hematopoietic stem cells and progenitors。 4,5...
08-12-28摘要:【摘要】 Objective- The flow-responsive Kruppel-like factor 2 (KLF2) is crucial for maintaining endothelial cell quiescence。 Here, we describe its detailed effects on transforming growth fact...
08-12-28摘要:18-19Gene ExpressionNo effect from the patients。 Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease。 Increased glucocorticoid activity in men with cardiovascula...
08-12-28摘要:【摘要】 Objective- Intracellular tumor necrosis factor receptor-associated factors (TRAFs) translocation to lipid rafts is a key element in CD40-induced signaling。 The purpose of this study ...
08-12-28摘要:Conclusions- Endothelial E-selectin plays a crucial role in EPC-endothelial interaction in vitro。Overexpression of E-Selectin Without Cytokine Stimulation Induced EPC Recruitment to HUVEC Monolaye...
08-12-28摘要:【摘要】 Objective- VEGF-E NZ7 /PlGF molecules composed of Orf virus-derived VEGF-E NZ7 and human PlGF1 were previously proven to be potent angiogenic factors stimulating angiogenesis without ...
08-12-28摘要:ResultsVEGF Does Not Upregulate Endothelial Protein Expression of E-selectin, ICAM-1, or VCAM-1The effects of VEGF on CAM mRNA levels were measured in HUVECs by quantitative real-time reverse-trans...
08-12-28摘要:Sub-culture of these precursors for additional 4 days robustly generated, in a VEGF dose-dependent manner, mature endothelial cells。 Arterial marker genes were specifically expressed in cultures d...
08-12-28摘要:ResultsmDia 1/2 Signaling Regulates SMC-Specific TranscriptionTo test whether the RhoA effectors, mDia1 and mDia2, contribute to the regulation of SMC-specific transcription, we cotransfected murin...
08-12-28摘要:【摘要】 Objectives- Extracellular superoxide dismutase (ecSOD) lowers superoxide anions and maintains vascular nitric oxide level。 Extracellular superoxide dismutase in human tissues and hum...
08-12-28摘要:Oxidative stress is invariably increased in, and contributes importantly to, the pathophysiology of inflammation。Inflammation, AAA, and Oxidative StressMany studies published over the past decade ...
08-12-28摘要:【摘要】 Heparin cofactor II (HCII) has several biochemical properties that distinguish it from other serpins: (1) it specifically inhibits thrombin。 (2) the mechanism of inhibition involves ...
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