摘要:Fibrinogen and 24-hour BP had additive effects on silent cerebrovascular lesions。 3Fibrinogen is involved in primary hemostasis, platelet aggregation, and leukocyte-endothelial cell interaction, a...
08-12-28摘要:【摘要】 Objective- Thrombin activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis。 The aim of the present study was to investigate the possible association between TAFI and overa...
08-12-28摘要:【摘要】 Objective- Plasmin is a key enzyme in fibrinolysis。Plasmin is a key enzyme in fibrinolysis, although it is known to exert cellular effects。 8,9,10,11Plasmin, as a key enzyme in fibr...
08-12-28摘要:【摘要】 Objective- Xanthine oxidase (XO), a major source of superoxide, has been implicated in endothelial dysfunction in atherosclerosis。 Mechanisms, however, leading to endothelial XO acti...
08-12-28摘要:【摘要】 Objectives- The objective of this study was to examine determinants of excess coronary artery disease risk in UK South Asians, more prevalent in this population than UK Caucasians, by...
08-12-28摘要:【摘要】 Objective- Our objective was to evaluate the prognostic value of baseline plasma RANTES levels in patients with known or suspected coronary artery disease。 RANTES is a chemokine prod...
08-12-28摘要:ResultsIdentified Variants in Nuclear Receptor GenesWith PCR-DGGE analysis, we identified 4 variants with amino acid changes, ie, Asp140Asn and Gly395Glu in the PPAR gene, Pro12Ala in the PPAR 2 ge...
08-12-28摘要:Isolation and Identification of the Marker of InterestMammary secretomes were pooled and subjected to weak cation exchange chromatography (CM10 spin columns。 Identification the 18。 Identification...
08-12-28摘要:Cellular [ 3 H]DPPC UptakePhospholipid uptake in THP-1-derived macrophages was performed according to McCormack et al 30a with minor modifications。 Transfer of lipoprotein components to cells by P...
08-12-28摘要:We hypothesized that inhibitor of apoptosis protein (IAP) survivin regulates macrophage death in atherosclerosis。Methods and Results- Western blot analysis revealed discrete survivin expression in...
08-12-28摘要:【摘要】 Objective- Naturally occurring CD4 + CD25 + regulatory T cells (Tregs) exert suppressive effects on effector CD4 cells and downregulate experimental autoimmune disorders。 We investig...
08-12-28摘要:【摘要】 Objective- To identify early changes in vascular gene expression mediated by CD44 that promote atherosclerotic disease in apolipoprotein E (apoE)-deficient (apoE-/-) mice。Methods and...
08-12-28摘要:【摘要】 Objective- Western-type high-fat/high-cholesterol diets used to induce atherogenesis in low-density lipoprotein (LDL) receptor-deficient mice also lead to obesity with concomitant met...
08-12-28摘要:Methods and Results- We assessed the role of ox-LDL in endothelial dysfunction in a murine model of atherosclerosis (ApoE KO mice)。 Coronary arterioles from WT control and ApoE KO mice were isolat...
08-12-28摘要:Oral BH4 treatment may have nonspecific antioxidant effects。 Oral administration of BH4 appears to be safe in humans, thus further research is required to establish the potential of oral BH4 treat...
08-12-28摘要:【摘要】 Objective- To determine whether expression of the human CETP transgene protects against diet-induced atherosclerosis in SR-BI deficient mice。Methods and Results- SR-BI deficient (-/-...
08-12-28摘要:Conclusions- Deficiency of an antioxidative enzyme accelerates and modifies atherosclerotic lesion progression in apolipoprotein E-deficient mice。 2-4 Glutathione peroxidase-1 (GPx-1), the ubiquit...
08-12-28摘要:【摘要】 Objective- The objective of this study was to determine whether the deficiency of Niemann-Pick C1 Like 1 (Npc1l1) prevents atherosclerosis in apoE null mice。Methods and Results- Npc1...
08-12-28摘要:Methods and Results- Aortic segments from either C57BL/6 wild-type or atherosclerotic ApoE-KO mice underwent balloon angioplasty alone or balloon angioplasty and stenting with a 1。 In stented ApoE...
08-12-28摘要:【摘要】 Objective- Carbamylated low-density lipoprotein (LDL), the most abundant modified LDL isoform in human blood, has been recently implicated in causing the atherosclerosis-prone injurie...
08-12-28摘要:We investigated how the two vascular endothelial growth factor receptors VEGFR-1 and -2 regulate these events in chronically rejecting cardiac allografts。 Targeting VEGFR-1 with neutralizing antib...
08-12-28摘要:Reconstituted HDL (rHDL) augmented angiogenesis in ischemic hindlimb with enhanced incorporation of bone marrow-derived cells in new vessels。MethodsReconstituted HDLDiscoidal rHDL was prepared as ...
08-12-28摘要:JAK-STAT Signaling Is Also Required for the IFN- Induced Expression of MCP-1 in Macrophages: Role of CK2 and AKT in the Regulation of STAT1 ActivityPrevious analysis of the MCP-1 promoter in astroc...
08-12-28摘要:Activation of the MRE-Luciferase reporter adenovirus was measured at each dose of cortisol in the presence of vehicle or 10 µ。ResultsCVCs Express Functional Mineralocorticoid ReceptorsCVCs ar...
08-12-28摘要:【摘要】 Objective- Exercise training has been shown to restore vasodilation to nitric oxide synthase (NOS) activation in arterioles distal to coronary artery occlusion。 Because reactive oxyg...
08-12-28摘要:【摘要】 Objectives- Nitric oxide inhibits smooth muscle cell migration after arterial injury, but the detailed mechanism is not fully understood。 The sarco/endoplasmic reticulum calcium ATPa...
08-12-28摘要:【摘要】 Objective- Bone morphogenetic protein 4 (BMP-4) is a transforming growth factor ß。 G, Downregulation of BMP-4 expression in rat carotid arteries in organoid culture (for 24 hour...
08-12-28摘要:4MT-SP1/Matriptase Induces IL-8 and IL-6 mRNA Expression and Release Dependent on its Catalytic ActivityHUVECs showed a dose-dependent increase of IL-8 release after treatment with MT-SP1/matriptas...
08-12-28摘要:【摘要】 Objective- Human endothelial cells use the multidrug resistance protein-1 (MRP1) to export glutathione disulfide (GSSG)。 We investigated how MRP1 modulates blood pressure and vascula...
08-12-28摘要:【摘要】 Objective- Reactive oxygen species have been implicated as signaling molecules modulating the activity of redox-sensitive transcription factors such as nuclear factor kappa B (NF- B)。...
08-12-28摘要:【摘要】 Objective- Reduced levels and impaired function of endothelial progenitor cells (EPCs) foster development and progression of atherosclerotic lesions。 Endothelial nitric oxide synthas...
08-12-28摘要:Nuclear factor E2-related factor-2 (Nrf2) is a transcription factor orchestrating antioxidant and cytoprotective responses on oxidative and electrophilic stress, and it has been shown to have antii...
08-12-28摘要:【摘要】 Platelet adhesion and aggregation at sites of vascular injury are two key events in hemostasis and thrombosis。 Their absence leads to highly impaired thrombus formation, independent ...
08-12-28摘要:This review summarizes factor IXa inhibitors, an emerging class of anticoagulants that includes active site-blocked inhibitors, monoclonal antibodies, oral inhibitors, and RNA aptamers。 Here, we s...
08-12-28摘要:See pages 697, 705, 969, and 973 and coverMice do not normally develop atherosclerosis, but can be induced to do so by feeding a diet high in fat。 Mice with targeted deletion of the gene for apoli...
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