摘要：The relative balance between clot formation and fibrinolysis is considered to reflect thrombotic potential following vascular injury。 The aims of the present study were to (1) to determine the con...

摘要：ResultsChanges in Serum Adiponectin and Fasting Blood Glucose Were Independently Associated With the PAI-1 Reduction in Rosiglitazone-Treated PatientsThe study subjects received add-on therapy with...

摘要：Cardiac glycosides such as ouabain and digoxin inhibit Na + /K + -ATPase activity in a very specific manner。 Cardiac glycosides specifically inhibit Na + /K + -ATPase activity by binding to its su...

摘要：Atrial fibrillation (AF) is associated with a high incidence of vascular disease that may be related to a prothrombotic and inflammatory state。 Soluble CD40 ligand (sCD40L), which stems essentiall...

摘要：Low C1-INH levels at 6-weeks postsurgery predicted the development of an early restenosis, indicating that it might be a marker in the identification of patients with high risk for early restenosis...

摘要：Inflammatory mediators were assayed。 Coronary sinus plasma concentrations of TNF- and IL-6 in the standard and high dose treatment groups before aortic clamping (&ndash。 Inflammatory response aft...

摘要：To investigate free interleukin-18 (fIL-18) levels, and variation within the IL-18 system genes, in heart surgery patients, and healthy men。 fIL-18 was calculated from IL-18 and IL-18 binding prot...

摘要：A common haplotype of the upstream transcription factor 1 gene ( USF1 ) has been associated with decreased susceptibility to familial combined hyperlipidemia (FCHL) and, paradoxically, with increas...

摘要：Incident cases of CHD (in those without baseline CHD) were defined as any of CHD death (ICD10 codes I20-I25, I51。 Incident cases of stroke (in those without baseline stroke) were defined as either...

摘要：【关键词】 inflammation atherosclerosis cardiovascular diseases myocardial infarction metalloproteinases IntroductionMatrix metalloproteinases (MMPs) are involved in the breakdown of the extrace...

摘要：10 Superoxide production by vascular oxidases is much less than that in macrophages。Quantification of Atherosclerotic LesionsAtherosclerosis in the aortas was measured by quantitation of oil red O...

摘要：Previous studies have indicated that the hyperlipidemia and gene expression changes induced by a short-term high-fat diet (HFD) are mediated through the peroxisome proliferator-activated receptor c...

摘要：Integrins, heterodimeric mediators of inflammatory cell recruitment, are not generally thought to be affected by diet。 However, high-fat feeding promotes inflammation, atherosclerosis, and death i...

摘要：Leptin receptor-deficient ( db/db ) mice display marked increase in the number and suppressive function of Treg cells。Leptin, a hormone that increases with obesity, was suggested to either acceler...

摘要：Whereas growth factors, via their ability to stimulate vascular smooth muscle cell (VSMC) proliferation and migration, have been thought to play a permissive role in atherosclerosis initiation and ...

摘要：HSP60-specific T cells contribute to the development of the immune responses in atherosclerosis。 This can be dampened by regulatory T cells activated via oral tolerance induction, and we explored ...

摘要：L) was isolated using a standard phenol-chloroform extraction protocol and amplified by touchdown PCR using fluorescently labeled primers from Research Genetics (Huntsville, Ala)。ResultsGenetic De...

摘要：ResultsCirculating Mediators of EPC Mobilization Are Increased in Children With Infantile HemangiomaMMP-9 and VEGF-A play significant roles in the mobilization of EPCs from the bone marrow。Mediato...

摘要：Therefore, we assessed the effect of the expression of a recently identified missense genetic variant of adenylyl cyclase isoform 6 (ADCY6 S674)。 In rat vascular smooth muscle cells, gene transfer...

摘要：Physical inactivity was associated with the development of insulin resistance, dyslipidemia, increased blood pressure, and impaired microvascular function in healthy volunteers。Physical inactivity...

摘要：Statins have been shown to increase endothelial nitric oxide synthase expression via enhanced mRNA stability。 Because the poly(A) tail is an important determinant of transcript stability, we sough...

摘要：APC is an antithrombotic and antiinflammatory serine protease that plays an important role in vascular function。 We report that APC can suppress the proapoptotic mediator TRAIL in human umbilical ...

摘要：Oxidative stress was measured by fluorescence microscopy and by electron spin resonance (ESR) using the free radical probe TEMPO-9AC。 Rosiglitazone attenuates atherosclerosis in a model of insulin...

摘要：Tie2 and its ligands, the angiopoietins (Ang), are required for embryonic and postnatal angiogenesis。 Previous studies have demonstrated that Tie2 is proteolytically cleaved, resulting in the prod...

摘要：Ruthenium red and the combination of charybdotoxin and apamin prevented the latter effect, suggesting that Trp channel activation increases Ca 2+ influx and prolongs the activation of Ca 2+ -depend...

摘要：FXR Ligands Inhibit IL-1&beta。FXR Ligands Downregulate RASMC MigrationPDGF-BB (25 ng/mL) but not IL-1&beta。FXR Ligands Inhibit Human Aortic Vascular Smooth Muscle Cell ResponsesFXR mRNA was prese...

摘要：RhoB is a small GTPase localized at the plasma membrane and endosomes that participates in the regulation of endocytic trafficking of the epidermal growth factor (EGF) receptor and the nonreceptor ...

摘要：Ldlr &ndash。/&ndash。 Because elevated TNF- is characteristic of obesity with T2DM, we examined contributions of this inflammatory cytokine。 HFD promoted obesity, hyperglycemia, and hyperlipidemi...

摘要：The goal of this study was to test the hypothesis that IL-6 mediates the increases in superoxide, vascular hypertrophy, and endothelial dysfunction in response to angiotensin II (Ang II)。 Response...

摘要：The mechanism and role of angiotensin II&ndash。induced vascular endothelial injury is unclear。 We examined the molecular mechanism of angiotensin (AII)-induced vascular endothelial injury and its...

摘要：Local delivery of 7ND through a gene-eluting stent may have advantages beyond those of the current first-generation DES devices: 7ND does not affect endothelial regeneration and proliferation 11 an...

摘要：Choroidal neovascularization (CNV) is a critical pathogenesis in age-related macular degeneration, the most common cause of blindness in the developed countries。 The aim of the current study was t...

摘要：ResultsIdentification of Novel HIF-Stimulating CompoundsThirty-seven compounds that have structural similarities to FG-0041, a previously reported PHD inhibitor supposedly acting through iron chela...

摘要：Because HIF-1 can be activated under normoxic conditions in smooth muscle cells (SMCs) by platelet products, we investigated the role of HIF-1 in SDF-1 &ndash。 HIF-1 expression was increased in th...