摘要：of Medicine III, University of Frankfurt, 60950 Frankfurt, Germany 2 Department of Dermatology and Allergology, University of Ulm, Ulm, 89069 Germany 3 Department of Internal Medicine I, University...

摘要：Just as potentially useful T cells are positively selected by MHC–peptide complexes in the thymus, it has been proposed that self or commensal bacterial epitopes might select B cell populations wi...

摘要：Here, using Spred-1–deficient mice, we demonstrated that Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness, without affecting helper T cell differentiation。...

摘要：Here, we present the isolation from a spleen extract and the functional characterization of F2L, a novel chemoattractant peptide acting specifically through FPRL2。 Therefore, no high affinity endo...

摘要：1 Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 2 EBV Biology Laboratory, Division of Immunology and Infecti...

摘要：A major regulator of neutrophil functional longevity is the ability of these cells to undergo apoptosis。 We examined the mechanism by which hypoxia causes an inhibition of neutrophil apoptosis in ...

摘要：1 Department of Immunology, Landspitali-University Hospital, 101 Reykjavik, Iceland 2 The Icelandic Heart Association, Heart Preventive Clinic and Research Institute, 201 Kopavogur, Iceland Inflamm...

摘要：Department of Microbiology and Immunology, University of Louisville Health Science Center, Louisville, KY 40202 The CD4+ CD25+ regulatory T cells play a critical role in controlling autoimmunity, b...

摘要：We now report that IL-21 synergistically acts with IL-15 to potently promote the proliferation of both memory (CD44high) and naive (CD44low) phenotype CD8+ T cells and augment interferon- productio...

摘要：Louis, MO 63110 The CD4 coreceptor works together with the T cell receptor (TCR) to deliver signals to the developing thymocyte, yet its specific contribution to positive selection and CD4 lineage ...

摘要：1 Rheumatology Unit, Department of Medicine 2 Department of Women and Child Health, Karolinska Institutet, 171 76 Stockholm, Sweden 3 Department of Clinical Neuroscience, Karolinska Institutet, 171...

摘要：Accumulating evidence suggests that HZ is immunologically active, but the molecular mechanism(s) through which HZ modulates the innate immune system has not been elucidated。 This work demonstrates...

摘要：Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY 10010 The circumsporozoite protein (CSP) is the major surface protein of Plasmodium sporozoite...

摘要：1 Division of Immunology, Children‘s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115 2 Institute of Molecular and Cell Biology, Singapore 117609 3 Department of Imm...

摘要：Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153 Gut-associated lymphoid tissues (GALTs) interact with intestinal microflora to dr...

摘要：1 Department of Pathology, College of Medicine 2 Graduate School of Immunology, College of Medicine 3 Rheumatism Research Center, College of Medicine 4 Natural Products Research Institute, College ...

摘要：We have shown previously that this activation occurs as a direct consequence of extracellular signal–regulated kinase 1/2–mediated phosphorylation at Ser225, which not only increases catalytic ac...