摘要：1 Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129 2 Pulmonary and...

摘要：Here we report on advances from the recent Keystone Symposium, “Dendritic Cells at the Center of Innate and Adaptive Immunity,“ organized in Vancouver, BC on Feb。 Although various kinds of cells...

摘要：Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455 Sequential rearrangement of the T cell receptor for antigen (TCR) and chains i...

摘要：Trudeau Institute, Saranac Lake, NY 12983 Although the absolute number of memory CD8+ T cells established in the spleen following antigen encounter remains stable for many years, the relative capac...

摘要：We show that plasmacytoid predendritic cells (PDCs), the natural interferon (IFN)-–producing cells, infiltrate the skin of psoriatic patients and become activated to produce IFN- early during dise...

摘要：1 The Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami, Miami, FL 33136 2 Neuroscience Program, Miller School of Medicine, University of Miami, Miami, FL 33136 3 Depa...

摘要：Here we show that ligand-independent and ligand-dependent activation of Notch1 induces transcription of the S phase kinase–associated protein 2 (SKP2), the F-box subunit of the ubiquitin-ligase co...

摘要：, Tokyo 100-0011, Japan Although the concept of a leukemic stem cell system has recently been well accepted, its nature and the underlying molecular mechanisms remain obscure。 Constitutive activat...

摘要：1 Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Unité Institut National de la Santé et de la Recherche Medicale 429, Hpital Necker Enfants-Malades, 75015 Paris, Fr...

摘要：1 Department of Environmental Health Sciences, Bloomberg School of Public Health 2 Department of Oncology, Sidney Kimmel Comprehensive Cancer Center 3 Department of Medicine, School of Medicine, Jo...

摘要：Instead, replenishment depends on recruitment of bone marrow–derived progenitors that circulate in the blood。 Thymic replenishment depends on bone marrow input Blood cells are subject to constant...

摘要：In mice that express transgenes controlled by peripheral tissue-specific promoters, a scattered subset of mTECs express the transgenic antigen, and this expression is sufficient to tolerize the dev...

摘要：1 Division of Developmental Immunology, German Cancer Research Center, D-69120 Heidelberg, Germany 2 Division of Theoretical Bioinformatics, German Cancer Research Center, D-69120 Heidelberg, Germa...

摘要：Department of Developmental Immunology, Max-Planck-Institute for Immunobiology, 79108 Freiburg, Germany Hematopoietic precursors continuously colonize the thymus where they give rise mainly to T ce...

摘要：1 Institut National de la Santé et de la Recherche Médicale, Unité 601 2 Unit of Skin Cancer, Centre Hospitalier Régional Hotel Dieu, 44093 Nantes Cedex 1, France 3 Faculté des Sciences et Tec...

摘要：1 The Jackson Laboratory, Bar Harbor, ME 04609 2 Section of Immunobiology, Yale University, New Haven, CT 06520 3 Cancer Research Center, Moscow 115478, Russia MHC molecules associated with autoimm...

摘要：1 Laboratory of Gene Therapy Research, Copenhagen University Hospital, 2100 Copenhagen, Denmark 2 Granulocyte Laboratory, Copenhagen University Hospital, 2100 Copenhagen, Denmark 3 Department of St...