摘要：The fusion of cells is a fundamental biological event that is essential for a variety of developmental and homeostatic processes。 Fusion is required for the formation of multinucleated osteoclasts...

摘要：Department of Immunology, Duke University Medical Center, Durham, NC 27710 Apoptosis-related genes play important roles in thymocyte maturation。 We show that cellular FLICE-like inhibitory protein...

摘要：1 Campbell Family Institute for Breast Cancer Research, University Health Network 2 Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 2C1, Canada 3 Ontario Cancer Insti...

摘要：1 Department of Pathology, Peking University, Beijing, China 100083 2 Department of Microbiology, Peking University, Beijing, China 100083 3 Beijing Ditan Hospital, Beijing, China 100011 4 State Un...

摘要：Plasmacytoid DCs (pDCs) are known to migrate to inflamed LNs and produce interferon (IFN)-, but their other roles in antiviral T cell immunity are unclear。 We report that LN-recruited pDCs are act...

摘要：We previously demonstrated that Tim-3 is expressed on terminally differentiated T helper (Th)1 cells, and serves to regulate Th1 immune responses。 Here, we describe the identification and function...

摘要：1 Institute for Virology and Immunobiology, University of Würzburg 2 Department of Neurology, University Hospital Würzburg, D-97078 Würzburg, Germany 3 TeGenero ImmunoTherapeutics AG, D-97076 Wü...

摘要：1 Department of Microbiology and Immunology, Weill Medical College of Cornell University 2 Department of Pharmacology, Weill Medical College of Cornell University 3 Department of Pathology and Labo...

摘要：The autoimmune disease systemic lupus erythematosus (SLE) is caused by a failure of B cell tolerance。 Recent studies in mouse models of SLE have identified several distinct tolerance checkpoints t...

摘要：1 Department of Cell Differentiation, The Sakaguchi Laboratory 2 Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan 3 Departme...

摘要：Louis, MO 63110 4 Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Seiryo 4-1, Aoba-ku, Sendai 980-8575, Japan 5 Core Research for Evolutional S...

摘要：Here, we show that CD28 engagement induced protein arginine methyltransferase activity and methylation on arginine of several proteins, including Vav1。 Methylation of Vav1 and IL-2 production were...

摘要：1 Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, England, UK 2 Department of Haematology, Queen Elizabeth Hospital, Birmingham B15 2TH, England, UK 3...

摘要：, San Diego, CA 92121 3 Tohoku University Graduate School of Engineering, Sendai 980-8579, Japan 4 Netherlands Cancer Institute, Division of Experimental Therapy, 1066 CX Amsterdam, Netherlands In ...