摘要：1 Gastroenterology Division, Department of Medicine, Brigham and Women‘s Hospital, Harvard Medical School, Boston, MA 02115 2 Program in Immunology, Division of Medical Sciences 3 Division of Hema...

摘要：Plasmacytoid dendritic cells (pDCs) are specialized producers of type I interferons (IFNs) that respond to most viruses。 Because of their antiviral activity and regulatory functions in innate and ...

摘要：1 Immunology Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101 2 Department of Immunology, University of Washington School of Medicine, Seattle, WA 98101 3 Amgen Corporation...

摘要：Department of Molecular Microbiology and Immunology, Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205 IL-4 receptor (IL-4R)-deficient CD8...

摘要：This unique recombination event involves formation of double-strand breaks (DSBs) in immunoglobulin switch (S) regions, and requires activation-induced cytidine deaminase (AID), which converts cyto...

摘要：Department of Immunology, Duke University Medical Center, Durham, NC 27710 Murine Tcrd and Tcra gene segments reside in a single genetic locus and undergo recombination in CD4–CD8– (double negati...

摘要：It is considered a severe variant of multiple sclerosis (MS), and frequently is misdiagnosed as MS, but prognosis and optimal treatments differ。 A serum immunoglobulin G autoantibody (NMO-IgG) ser...

摘要：1 Integrated Department of Immunology, National Jewish Medical and Research Center and University of Colorado Health Sciences Center 2 Department of Pathology, University of Colorado Health Science...

摘要：1 Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas–Universidad Autónoma de Madrid, Madrid 28049, Spain 2 Centro Nacional de Biotecnología, Consejo Sup...

摘要：1 Committee on Immunology, The University of Chicago, Chicago, IL 60637 2 Department of Molecular Biology, Princeton University, Princeton, NJ 08544 3 Department of Immunology, The Scripps Research...

摘要：We report that pharmacologic inhibition of 11-HSD1 has a therapeutic effect in mouse models of metabolic syndrome。 Administration of a selective, potent 11-HSD1 inhibitor lowered body weight, insu...

摘要：1 Department of Pathology, Harvard Medical School 2 Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115 Differentiation of B cells into plasma cells ...