摘要：1 Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, 2 B Cell Biology Group and Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin...

摘要：Airway Disease Section, National Heart and Lung Institute, Imperial College, London SW3 6LY, England, UK Glucocorticoids are the most effective antiinflammatory agents for the treatment of chronic ...

摘要：Department of Pathology, Institute of Cancer and Stem Cell Biology and Medicine, Stanford University School of Medicine, Stanford, CA 94305 In the absence of irradiation or other cytoreductive cond...

摘要：1 Department of Cardiology and Angiology, Interdisciplinary Center for Clinical Research Münster, 2 Department of Medicine/Hematology and Oncology, 3 3 Department of Neurology, and Leibniz Instit...

摘要：Here, we have studied the role of ataxia telangiectasia and Rad3-related protein (ATR) in CSR by analyzing the recombinational junctions, resulting from in vivo switching, in cells from patients wi...

摘要：Department of Immunology, Duke University Medical Center, Durham, NC 27710 Engagement of the T cell receptor for antigen (TCR) induces formation of signaling complexes mediated through the transmem...

摘要：Mitogen-activated protein (MAP) kinase cascades are crucial in the biosynthesis of proinflammatory cytokines。 MAP kinase phosphatase (MKP)-1 is an archetypal member of the dual specificity protein...

摘要：The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues。 RI, ...

摘要：Elizabeth‘s Medical Center, Tufts University School of Medicine, Boston, MA 02135 2 Division of Hematology, Department of Medicine, University of Washington, Seattle, WA 98195 3 Regenerative Medic...

摘要：, NCI-Frederick Cancer Research and Development Center, Frederick, MD 21702 Death by neglect requires that CD4+8+ double-positive (DP) thymocytes avoid cytokine-mediated survival signals, which is ...

摘要：1 Department of Dermatology and Section for Pathophysiology, First Department of Internal Medicine, Johannes Gutenberg-University, Mainz 55131, Germany 2 Laboratory of Parasitic Diseases, National ...

摘要：Here, we identify the MAPK phosphatase dual specificity phosphatase 1 (DUSP1) as an essential endogenous regulator of the inflammatory response to lipopolysaccharide (LPS)。 DUSP1-deficient (DUSP1–...

摘要：1 The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassah Medical School 2 Department of Pharmacology, Faculty of Dental Medicine Founded by the Alpha-Omega Fraterni...

摘要：1 Department of Pathology, Comprehensive Cancer Center, 2 Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109 3 Department of Chemistry, Graduate School of Science, O...

摘要：AID-dependent double-strand breaks (DSBs) are introduced into switch (S) regions and stimulate CSR。 Although histone acetylation (Ac) has been well documented in transcription regulation, its role...

摘要：Institute for Research in Biomedicine, CH-6500 Bellinzona, Switzerland Flt3 ligand (Flt3L) is a nonredundant cytokine in type I interferon–producing cell (IPC) and dendritic cell (DC) development,...

摘要：Here, we show that plaque-infiltrating CD4 T cells effectively kill vascular smooth muscle cells (VSMC)。 VSMCs sensitive to T cell–mediated killing express the death receptor DR5 (TNF-related apo...

摘要：These secretory antibodies (SAbs) may bind multiple antigens and are thought to eliminate commensal bacteria and self-antigens to avoid systemic recognition。, those that are continuously produced ...

摘要：James‘s University Hospital, Leeds LS9 7TF, England, UK 4 Department of Haematology, Christie Hospital NHS Trust, Manchester M20 4BX, England, UK 5 Department of Haematology, Royal Free and Univer...

摘要：1 Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 2 Bureau of State Laboratory Services and Bureau of Ep...

摘要：Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 Apolipoprotein B mRNA-editing enzyme-catalytic polypept...

摘要：Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 The T cell receptor for antigen (TCR) comp...

摘要：1 Department of Pathology, Department of Surgery, and Department of Internal Medicine, The University of Michigan Medical School, Ann Arbor, MI 48109 Defective cardiac function during sepsis has be...