摘要：1 Institute for Cancer Genetics and The Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032 2 Laboratory of Cancer Genetics and the Department of Medicine, Memorial ...

摘要：KLRG1 inhibits effector cell responses KLRG1 is a transmembrane receptor belonging to the lectin-like superfamily, which mediates inhibition via a cytoplasmic ITIM motif。 The inhibitory function o...

摘要：1 Department of Toxicogenetics, Leiden University Medical Center, 2300 RC Leiden, Netherlands 2 Division of Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands Somatic hype...

摘要：To examine this issue, we backcrossed mice lacking the PGI receptor (IP) to the DBA/1J strain and subjected them to collagen-induced arthritis (CIA)。 However, a partial but significant suppression...

摘要：1 Third Medical Department, Klinikum rechts der Isar and Institute for Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, 81675 Munich, Germany 2 ZAUM-Center for Allergy...

摘要：1 Department of Medicine, Department of Molecular Microbiology and Immunology, 2 Department of Veterinary Pathobiology, and VA Research Service, University of Missouri, Columbia, MO 65212 Wild-typ...

摘要：We postulated that this paradoxical situation would correspond to a disequilibrium between effector and regulatory T lymphocytes (T reg cells)。 We show that CD4+CD25brightFoxP3+ cells accumulate a...

摘要：, San Francisco, CA 94080 5 Laboratory of Leukemia Diagnostics, Department of Internal Medicine III 6 CCG Acute Leukemias, GSF National Research Center of Environment and Health, D-81377 Munich, G...

摘要：1 Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536 2 Department of Microbiology and Molecular Genetics, Harvard Medica...

摘要：1 Laboratory of Molecular Immunology, The Rockefeller University, 2 Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 3 Howard Hughes Medical Institute, New York, NY 10021 4 FU-Ber...

摘要：Paul, MN 55144 3 Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520 4 Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, ...

摘要：Blockade of this enzyme by atorvastatin (AT) inhibits the destructive proinflammatory T helper cell (Th)1 response during experimental autoimmune encephalomyelitis and may be beneficial in the trea...

摘要：The Toll-like receptors (TLRs) help detect foreign invaders by sensing various pathogen-associated molecules, including microbial RNA and DNA。 In addition, recent studies have revealed the existen...

摘要：1 Laboratory of Molecular Immunology and Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021 Unlike T-dependent immune responses against protein antigens, T-independent ...

摘要：We investigated the role of PAR2 in the pathogenesis of multiple sclerosis (MS) in humans and experimental autoimmune encephalomyelitis (EAE) in mice。 EAE, experimental autoimmune encep-halomyelit...

摘要：These phenomena have led to the hypothesis that antigen presentation within the liver is abortive, leading to T cell tolerance or apoptosis。 In direct contradiction to this model, the liver itself...

摘要：Department of Pathology, University of Chicago, Chicago, IL 60637 The major histocompatibility complex (MHC) class Ib molecule H2-M3 primes the rapid expansion of CD8+ T cells by presenting N-formy...

摘要：1 Institute for Research in Biomedicine, CH-6500 Bellinzona, Switzerland 2 Department of Medical Pharmacology, CNR Institute of Neuroscience, Cellular and Molecular Pharmacology, Center of Excellen...

摘要：Anderson Cancer Center, Houston, TX 77030 Thymic stromal lymphopoietin (TSLP) is an interleukin (IL) 7–like cytokine that triggers dendritic cell–mediated T helper (Th)2 inflammatory responses。 ...

摘要：1 The Jackson Laboratory, Bar Harbor, ME 04605 2 Department of Internal Medicine, Division of Rheumatology, The University of New Mexico, Albuquerque, NM 87122 Rheumatoid arthritis (RA) is a comple...

摘要：1 Department of Microbiology and Immunology and Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 T cell–specific adapter protein (TSAd) is a SRC-homology-2 (SH2)...

摘要：Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, 277-8562 Chiba, Japan Killer cell lectin-like receptor G1 (KLRG1) is an inhibitory rece...

摘要：Genomic Instability Group, Spanish National Cancer Center, Madrid 28029, Spain DNA double-strand breaks (DSBs) are among the most deleterious lesions that can challenge genomic integrity。 In this ...