摘要：In jawed vertebrates, nucleic acid–sensing receptors induce the production of type I interferons (IFNs)。 Cell-autonomous defense: beyond type I IFNs The observation that IPS-1–deficient mice are...

摘要：1 Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia 2 Institute for Virology, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, German...

摘要：Transplant Research Center, Department of Medicine and Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215 Natural killer (NK) cells are programmed ...

摘要：Vincent‘s Cancer Center, New York, NY 10021 4 Hematology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021 Infiltration by dendritic cells (DCs) is a common feature of most human...

摘要：Department of Immunology, Duke University Medical Center, Durham, NC 27710 The mechanism of lineage commitment from hematopoietic stem cells (HSCs) is not well understood。 Although commitment to e...

摘要：Here, we demonstrate a key role of interleukin (IL)-27 in regulating this critical balance。 IL-27 was rapidly induced during murine experimental peritonitis induced by cecal ligation and puncture ...

摘要：1 Kennedy Institute of Rheumatology Division, Imperial College London, Hammersmith, London W6 8LH, United Kingdom 2 Leibniz Institute for Age Research, Fritz-Lipmann-Institute, D-07745 Jena, German...

摘要：1 Autoimmunity and Inflammation Program, Hospital for Special Surgery 2 Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021 Lymph nodes grow r...

摘要：1 Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021 2 Graduate Program in Immunology, Weill Graduate School of Medical Sciences of Cornell University, New ...

摘要：1 Inositide Laboratory 2 Laboratory of Molecular Signalling, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, UK The generation of reactive oxygen species (ROS) by the reduced ...

摘要：1 Department of Pediatrics (Hematology/Oncology), Herman B Wells Center for Pediatric Research, Riley Hospital for Children, 2 Department of Microbiology/Immunology, 3 Department of Medical and Mol...

摘要：Louis, Paris, F-75010 France Neisseria meningitidis is a commensal bacterium of the human nasopharynx。 Occasionally, this bacterium reaches the bloodstream and causes meningitis after crossing the...

摘要：Michael‘s Hospital and University Health Network, and Department of Surgery, University of Toronto, Toronto, Ontario, M5G 2C1, Canada Oxidative stress generated by ischemia/reperfusion is known to...

摘要：Dorris Neurological Research Institute, The Scripps Research Institute, La Jolla, CA 92037 Given the global impact of persistent infections on the human population, it is of the utmost importance t...

摘要：Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115 Despite many efforts, the nature of thymic immigrants that give rise to T cells has remained obscure, especially since it beca...

摘要：Surprisingly, anti-GPI B cells were not tolerant to this ubiquitously expressed and circulating autoantigen。 Instead, they were found in two functionally distinct compartments: an activated popula...

摘要：1 Dynavax Technologies Corporation, Berkeley, CA 94710 2 Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109 Human plasmacytoid dendritic cells (PDCs) can produce int...

摘要：1 Institute for Molecular Biotechnology of the Austrian Academy of Sciences, A-1030 Vienna, Austria 2 Graduate Programme in Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada 3 Dep...

摘要：1 Transplantation Biology Research Center, Bone Marrow Transplantation Section, 2 Wellman Center for Photomedicine, 3 Center for Immunology and Inflammatory Diseases, Massachusetts General Hospit...

摘要：1 Institute of Experimental Immunology, University Hospital Zürich, 8091 Zürich, Switzerland 2 Mettler-Toledo (Schweiz) GmbH, 8606 Greifensee, Switzerland The biological relevance of nonneutraliz...