摘要：Arrestins also function as scaffolds and transducers of mitogen-activated protein (MAP) kinase signaling cascades。 Arrestins interact with phosphorylated GPCRs and bind to clathrin and adaptor pro...

摘要：Cardiovascular Actions of PARs PAR Actions in the Vasculature。 PAR Actions in the Heart PAR-1 Actions in Cardiomyocytes。 Cardiac Actions of PAR-2。 Cardiac Actions of PAR-4。

摘要：Lees MJ and Whitelaw ML (1999) Multiple roles of ligand in transforming the dioxin receptor to an active basic helix-loop-helix/PAS transcription factor complex with the nuclear protein Arnt。

摘要：The combination of this information with the high abundance of CSQ in SR and the high membrane permeability of those drugs led us to the specific hypothesis that there are undesirable and damaging ...

摘要：Department of Pharmacology, College of Medicine, University of California, Irvine, Irvine, California Abstract Estrogen receptor regulation of nitric oxide production by vascular endothelium may in...

摘要：) Abstract Ectonucleoside triphosphate diphosphohydrolases (NTPDases) control the concentration of released extracellular nucleotides, but the precise physiological roles played by these isozymes i...

摘要：(-)-Epibatidine, carbamylcholine, proadifen, fetal calf serum, and bovine serum albumin were purchased from Sigma (St。 Homology Modeling and Epibatidine Docking。 Effects of Previously Identified ...

摘要：Palmitoylation has been demonstrated to occur on RGS7 when expressed in Sf9 insect cells (Rose et al。 Palmitoylation Assay。 Results o Specifically Promoted PM Targeting of 5RGS7。 o Induced Palmi...

摘要：Two conclusions can be drawn from these observations: 1) the bell-shaped concentration response-curve for PCA is in agreement with our double-barrel model depicted in Fig。 Farhan H, Korkhov VM, Pa...

摘要：Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania Abstract Protein kinase C (PKC) and protein kinase D (PKD) coordinate and regulate many fundamental cellular processes...

摘要：Sustained ICl(Ca) evoked by intracellular Ca2+ clamped at 500 nM were dose-dependently inhibited by NFA (IC50 = 159 e) and transiently augmented in a concentration-independent manner (10 e to 1 mM)...

摘要：Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota Abstract Natriuretic peptide receptor A (NPR-A/GC-A) and B (NPR-B/GC-B) are members of ...

摘要：Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland Abstract A study in this issue of Molecular Pharmacology on agonist-induced internalization of e...

摘要：Histaminergic neurons modulate several physiological processes, such as sleep/wake cycles, food intake, and memory (Brown et al。 [3H]Histamine Purification by HPLC。 Histamine eluted isocratically...

摘要：[3H](-)-Cocaine was purchased from PerkinElmer Life and Analytical Sciences (Boston, MA)。 The final vectors, Ad5-CMV-CocE and Ad5-CMV-AME359, were assembled in the Gene Transfer Core Facility at t...

摘要：Division of Cell and Molecular Biology, Department of Biology, Boston University, Boston, Massachusetts Abstract Methoxymorpholinyl doxorubicin (MMDX) is a novel liver cytochrome P450 (P450)-activa...

摘要：RT-PCR Analysis of Alternative Splicing Variants of EPHX1 in Cultured Cells。 Results Alternative Exon Usage for Human EPHX1。 Nanbru C, Lafon I, Audigier S, Gensac MC, Vagner S, Huez G, and Prats ...

摘要：, San Diego, California Abstract Relaxin-3, the most recently identified member of relaxin/insulin family, is an agonist for leucine-rich repeat-containing G protein-coupled receptor (LGR)7, GPCR13...

摘要：Among the UGT enzyme family members, the UGT1A7, UGT1A8, UGT1A9, and UGT1A10 isoforms are issued from a single gene through differential splicing。 Indeed, UGT1A7, UGT1A8, and UGT1A10 are exclusive...

摘要：Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana Abstract Adenylyl cyclase type 6 (AC6) activity is inhibited by protein kinase C (PKC) in vi...

摘要：K) Abstract Coimmunoprecipitation was used to investigate protein-protein interactions between several UDP-glucuronosyltransferase (UGT) isoforms and cytochrome P450 3A4。

摘要：Vascular endothelial growth factor (VEGF) is probably the most widely acknowledged initiator of angiogenesis (Ferrara, 1999。 Cellular cAMP and cGMP levels are dynamically regulated by both the rat...

摘要：Chinetti G, Fruchart JC, and Staels B (2000) Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation。 Mandard S, Muller M...

摘要：Production of Recombinant Transporters and Measurement of Radioisotope Uptake in Oocytes of X。 Production of Recombinant Transporters and Measurement of Radioisotope Uptake in S。 Results Inward F...

摘要：Opioid Receptors。 Determination of Receptor Signaling, Desensitization, and cAMP Superactivation by Measurement of cAMP Accumulation。 Receptor desensitization was measured as the decreased abilit...

摘要：Receptors were immunoprecipitated from cell extracts using 3 e蘥 of anti-HA (HA。 Visualization of Receptor Trafficking by Fluorescence Microscopy。 Fluorescence Flow Cytometric Assay of Receptor R...

摘要：Cell Protein Extraction。 Proteins were transferred to polyvinylidene difluoride membrane, and incubated in blocking solution for 2 h。7-fold of positive control, respectively) Heterogeneous Compos...

摘要：) and Division of Molecular Pathogenesis, Department of Cell and Molecular Biology (M。 Materials and Methods Cell Culture, Mutation, and Transfection。 Cell Fractionation。 Cells were lysed in ice...

摘要：ATRA induced differentiation of HL-60 cells along the granulocytic pathway within 48 h。 The half-lives of bcl-2 mRNA in HL-60 cells incubated with ATRA for 48 or 72 h were reduced to 39 and 7% of ...

摘要：), Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia Abstract Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an environmental pollutant, has been shown to c...

摘要：Results Effect of Short-Term Inverse Agonist Pretreatment on Pharmacological Responses Elicited by Different OR Ligands。 Effect of Inverse Agonist Pretreatment on G Protein Immunoreactivity from C...

摘要：Abstract Nicotinic acetylcholine receptors (nAChRs) represent an important modulator of striatal function both under normal conditions and in pathological states such as Parkinson‘s disease。 1-Me...

摘要：Purification of GST-Fused PAM Proteins。 Proteins were eluted with 50 mM Tris-HCl, 2 mM DTT, 20 mM NaCl, and 10 mM glutathione。 Proteins were eluted with a gradient of 0 to 500 mM NaCl in 50 mM Tr...

摘要：Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden Abstract Proteochemometrics was applied in the analysis of the binding of organic compounds to wild-type and chimeric m...

摘要：Synthesis of Nonsteroidal Inhibitors: N-Phenylanthranilic Acid Derivatives The synthesis of the N-phenylanthranilic acid derivatives used the Ullmann-Goldberg reaction that couples benzoic acid and...

摘要：Wyeth Research, Cardiovascular and Metabolic Diseases, Cambridge, Massachusetts Abstract Ertiprotafib belongs to a novel class of insulin sensitizers developed for treatment of type 2 diabetes。 Er...