摘要：), Vanderbilt Center for Structural Biology (T。

摘要：Department of Pharmacology and Developmental and Cell Biology, University of California, Irvine, Irvine, California Abstract A tenet of pharmacology states that a receptor must be selective for and...

摘要：Institut du Thorax, Institut National de la Sante et de la Recherche Medicale U533, Facultee de Meedecine, Nantes, France (A。R。, G。T。, C。G。) Laboratoire de Pharmacologie de la Facultee de Pha...

摘要：Neuropeptide Y (NPY)-related peptides comprise both a neuromodulator (NPY) and hormones [peptide YY (PYY) and pancreatic polypeptide] whose widespread distribution contributes to a diversity of phy...

摘要：) Abstract Modulation of UDP-glucuronosyltransferase 2B7 (UGT2B7)-catalyzed morphine glucuronidation by cytochrome P450 (P450) was studied。 Ikushiro S, Sahara M, Emi Y, Yabusaki Y, and Iyanagi T (...

摘要：) Abstract Urinary trypsin inhibitor (UTI), a serine protease inhibitor, has been widely used as a drug for patients with acute inflammatory disorders such as disseminated intravascular coagulation...

摘要：Peroxisome proliferators (PP) alter a subset of these changes in wild-type mice through activation of the nuclear receptor family member PP-activated receptor (PPAR)。 Analysis of Gene Expression b...

摘要：GRIN1 was isolated through screening of a mouse embryo cDNA expression library with phosphorylated guanosine 5‘-3-O-(thio)triphosphateeCGz as a probe。 In this experiment, Swiss 3T3 cells were use...

摘要：Of these residues, all except Tyr702 are conserved among AMPA receptors。00 to determine the EC50 and Hill value (nH), using the logistic equation: I = Imax/(1 + 10(log[EC50])/10(log ))nH,...

摘要：Departments of Surgery (G。P。L。, M。K。M。) and Radiology (R。W。P。) and McArdle Laboratory for Cancer Research (E。G。, H。C。P。, C。A。B。), University of Wisconsin Medical School, Madison, W...

摘要：Platelet Preparation。 Platelets or cells were then restimulated with ADPS (10 e), the nonhydrolyzable analog of ADP。 Preparation of Human Platelet Membranes。 Platelet plasma membranes were prepa...

摘要：A pull-down study using recombinant C-terminal proteins of OCTs and OCTNs identified a specific interaction of apical transporters OCTN1 and OCTN2, but not basolateral transporters OCT1 and OCT2, w...

摘要：Institute of Physiology I, University of Tuebingen, Tuebingen, Germany Abstract Cation channels are membrane proteins that provide controlled pathways for ion passage through cellular membranes。 C...

摘要：(2001) Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity。

摘要：Edwards RH (2001) Drug delivery via the blood-brain barrier。

摘要：Protein content of the supernatants was determined using the Bio-Rad protein assay reagent。 Proteins were visualized with the Amersham enhanced chemiluminescence system (Amersham Biosciences Inc。

摘要：Organotin compounds have been used as agricultural fungicides, rodent repellents, and molluscicides and in antifouling paints for ships and fishing nets (Piver, 1973。 Organotin compounds act as ag...

摘要：Materials and Methods Hippocampal Cultures。 Hippocampal neuronal cultures were prepared according to the protocol described by Banker and modified for electrophysiology (Goslin et al。 Hippocampal...

摘要：) Abstract Serum response factor (SRF) is activated by contractile and hypertrophic agonists, such as endothelin-1 (ET1) to stimulate expression of cytoskeletal proteins in vascular smooth muscle c...

摘要：Results Activation of TRPM3 by SPH。 Specificity of the TRPM3 Activation by SPH。 Activation of TRPV4 is reported to be based on swelling-induced activation of phospholipase A2 and cytochrome P450 ...

摘要：) Abstract Human UMP/CMP kinase (cytidylate kinase。14 [EC] ) is responsible for phosphorylation of CMP, UMP, and deoxycytidine monophosphate (dCMP) and also plays an important role in the activati...

摘要：) Abstract Glucocorticoids are commonly used in the clinic, but long-term treatment is often associated with severe side effects。 Glucocorticoids are widely used in the clinic, but long-term treat...

摘要：We identified Met89 and Ser160 as important in the affinity of hENT1 for various substrates and inhibitors。 Mutation to Met89Cys or Ser160Cys significantly (p 0。05) increased the S6-(4-nitrobenz...

摘要：We recently reported the cloning and analysis of expression of a novel human family C G-protein-coupled receptor, termed hGPRC6A。24, containing the ligand binding amino-terminal domain (ATD) of hG...

摘要：) Abstract Polyamides are a class of synthetic molecules that exhibit high-affinity, sequence-specific reversible binding in the DNA minor groove but are incapable of inducing DNA damage。 By combi...

摘要：Groningen University Institute for Drug Exploration (GUIDE), Department of Cell Biology (M。B。, A。H。W。-K。, H。W。M。M。, G。L。S。, J。A。A。M。K。), Pathology and Laboratory Medicine/Medical ...

摘要：Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, Unitee Mixte Recherche 5089, Toulouse, France Abstract To elucidate the mechanism of the cellular...

摘要：Bres (Pharmacological Institute, University of Bonn, Bonn, Germany) and grown as described previously (Kaulich et al。 Functional Studies Cyclic AMP Accumulation。 Functional studies were additiona...

摘要：) Abstract Guggulsterone (GS) is the active substance in guggulipid, an extract of the guggul tree, Commiphora mukul, used to treat a variety of disorders in humans, including dyslipidemia, obesity...

摘要：) Department of Physics and Astronomy, University of Manitoba and Manitoba Centre for Proteomics, Winnipeg, Manitoba, Canada (O。) Abstract Cisplatin was shown to strongly inhibit the decatenation ...

摘要：Ouabain concentrations (100 nM or lower) that caused less than 25% inhibition of the pumping function of Na+/K+-ATPase had no effect on cell viability but inhibited proliferation。 At the same conc...

摘要：School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands Abstract The purpose of this ...

摘要：Laboratory of Molecular Immunology, National Heart, Lung Blood Institute, National Institutes of Health, Bethesda, Maryland Abstract The glucocorticoid dexamethasone suppresses antigen-induced degr...

摘要：Piascik MT and Perez DM (2001) 1-Adrenergic receptors: new insights and directions。

摘要：(2000) Human placental transport of vinblastine, vincristine, digoxin and progesterone: contribution of P-glycoprotein。

摘要：Laboratories of Biochemistry, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Abstract CYP2C11, the most commonly expressed hepatic cytochrome P450 isoform in ...

摘要：Departments of Medicinal Chemistry (M。T。) and Oncology (F。V。) Aventis Pharmaceuticals, Vitry-Sur-Seine, France Department of Drug Safety Evaluation, Aventis Pharmaceuticals, Bridgewater, New Je...

摘要：In multiple ChIP assays, ribosomal S6 kinase 4 (RSK4) and p21-activated kinase 5 (PAK5) were confirmed, and in vitro binding of HNF4 was evidenced by electrophoretic mobility shift assays (EMSA) us...

摘要：Reiners JJ and Clift RE (1999) Aryl hydrocarbon receptor regulation of ceramide-induced apoptosis in murine hepatoma 1c1c7 cells。

摘要：References Albano E, Rundgren M, Harvison PJ, Nelson SD, and Moldeus P (1985) Mechanisms of N-acetyl-p-benzoquinone imine cytotoxicity。 Drug Metab Dispos 18: 742eC745。 Drug Metab Dispos 12: 484eC...