摘要:) Abstract We tested several histamine H1 receptor (H1R) and antagonists for their differences in agonists binding affinities between human and guinea pig H1Rs transiently expressed in African gree...
07-05-15摘要:Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland Abstract Cell-penetrating pep...
07-05-15摘要:Meclofenamic acid and diclofenac are well known and widely used nonsteroidal antiinflammatory drugs (NSAIDs) acting as nonselective inhibitors of COX-1 and COX-2 (Furst and Munster, 2001)。 Diclofe...
07-05-15摘要:Molecular structures were used as either SMILES or sdf format and imported into Cerius2 version 4。 Comparative Molecular Field Analysis。 Substrate molecules were then aligned using hydrophobic, h...
07-05-15摘要:Transfected GT1-7 cells were preloaded with 1 e Fura-2/acetoxymethyl ester (Molecular Probes, Eugene, OR) for 60 min at room temperature in modified Krebs-Ringer buffer: 120 mM NaCl, 5 mM KCl, 1。 ...
07-05-15摘要:Manipulations that decreased levels of phosphatidylinositol-4,5-bisphosphate (PIP2) (e。 Results Effect of the Pleckstrin Homology Domain of Phospholipase C on the Actin Cytoskeleton。 Effect of Re...
07-05-15摘要:) Abstract Mammalian type I and II gonadotropin-releasing hormone (GnRH) receptors (GnRHRs) show differential ligand preference for GnRH-I and GnRH-II, respectively。 Using a variety of chimeric re...
07-05-15摘要:Role of GAGs in the Reduction of Env Disulfide Bonds during the Course of Interaction with the Lymphocyte Surface。 References Barbouche R, Miquelis R, Jones IM, and Fenouillet E (2003) Protein dis...
07-05-15摘要:By probing human and rat brain cDNA libraries to identify TRPV subunits, we identified a novel human TRPV1 RNA splice variant, TRPV1b, which forms functional ion channels that are activated by temp...
07-05-15摘要:Matrilysin (also called MMP-7) is the smallest member of the MMP family and lacks the hemopexin-like domain。 Matrilysin has been linked to a number of pathological processes ranging from inflammat...
07-05-15摘要:Preparation of Recombinant NSF and SNARE Polypeptides。 Fusion polypeptides composed of a TAT protein transduction domain joined to an NSF domain can enter endothelial cells, inhibit specific NSF a...
07-05-15摘要:) Abstract c-Src potentiates proliferation, survival, and invasiveness in response to epidermal growth factor (EGF) in human mammary carcinoma cells。 Tyrosine (Tyr) 845 of ErbB1 is phosphorylated ...
07-05-15摘要:Kim SJ, Veenstra-VanderWeele J, Hanna GL, Gonen D, Leventhal BL, and Cook EH Jr (2000) Mutation screening of human 5-HT2B receptor gene in early-onset obsessive-compulsive disorder。
07-05-15摘要:Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland (S。R。, C。J。C。, B。J。M。) Neurology CEDD, GlaxoSmithKline, ...
07-05-15摘要:) Abstract Sphingosine 1-phosphate (S1P) has been shown to exert a variety of biological responses through extracellular specific receptors or intracellular mechanisms。 In the present study, we ch...
07-05-15摘要:Topoisomerase I is primarily known as a DNA nicking/closing enzyme capable of resolving topological constraints in DNA (Wang, 2002)。 Selective inhibition of topoisomerase I from L。 Sequencing of ...
07-05-15摘要:Department of Biochemistry, Molecular Neuroscience Center Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China Abstract Tuber...
07-05-15摘要:Department of Cell Biology, Institut Cochin, Centre National de la Recherche Scientifique Unitee Mixte Recherche 8104, Institut National de la Sante et de la Recherche Medicale U567, Universitee Pa...
07-05-15摘要:Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon Abstract The aim of this study was to gain insight into the mechanism by which members of the ...
07-05-15摘要:Although several lines of evidence indicate that developmental changes of GABAergic synaptic current time course are clearly correlated with a switch in postsynaptic receptors, much less is known a...
07-05-15摘要:-Arrestins, in addition to regulating desensitization, have emerged as potential mediators of G-protein-independent signaling pathways and have been implicated in several chemotactic pathways。 Hum...
07-05-15摘要:GSK3 Immunoprecipitation and Activity Assay。 Kinase activity was assayed in a total volume of 15 e of kinase buffer containing 20 mM Tris, pH 7。 Kinase buffer without peptide was used as a contro...
07-05-15摘要:Fluorescence Experiments Undertaken in R-1Fs Epifluorescence Imaging of QAPB Binding to Spontaneously Recycling Bovine 1a-ARs。 Spontaneously recycling 1a-ARs were pre-equilibrated with QAPB (5 nM)...
07-05-15摘要:Laboratory of Environmental Toxicology, Departments of Pharmacology, Chemistry Biochemistry, University of California, San Diego, La Jolla, California Abstract We show here that arsenite (As3+) el...
07-05-15摘要:) Abstract Human hydroxysteroid sulfotransferase or (HUMAN)SULT2A1 catalyzes the sulfonation of procarcinogen xenobiotics, hydroxysteroids, and bile acids and plays a dynamic role in hepatic choles...
07-05-15摘要:5]undec-9-yl}methyl)phenyl]oxy}benzoic acid hydrochloride (873140) is a potent noncompetitive allosteric antagonist of the CCR5 receptor (pKB = 8。 In this article, the receptor-based mechanism of ...
07-05-15摘要:Lucia Foundation Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy University of Rome “Tor Vergata“, Rome, Italy Abstract Trace amines (TAs) are present in the central nervous syst...
07-05-15摘要:) Abstract Human equilibrative nucleoside transporters 1 and 2 (hENT1 and hENT2) differ functionally in that hENT2 generally displays lower affinity for its nucleoside permeants and is less sensiti...
07-05-15摘要:Arylamine N-acetyltransferases (NATs。 Results Presence of NAT Enzymes in Human Lens Epithelial Cells。
07-05-15摘要:Analysis of Clonogenicity and Apoptosis。 Results Overexpression of DDB2 in Cisplatin-Selected Cells Associated with Cross-Resistance to TNF Signaling-Mediated Apoptosis。 Overexpressing DDB2 Suppr...
07-05-15摘要:Department of Pharmacology, University of Bern, Bern, Switzerland Abstract Benzodiazepines are widely used as anxiolytics, sedatives, muscle relaxants, and anticonvulsants。 Benzodiazepines are mai...
07-05-15摘要:) Abstract Retigabine (RTG) is an anticonvulsant drug with a novel mechanism of action。2 (KCNQ2) channel, which is activated by RTG, and the cardiac Kv7。 Retigabine (RTG), a novel anticonvulsant,...
07-05-15摘要:Nuclear proteins were incubated with the 32P-labeled probe (10,000-15,000 cpm) in the mixtures including polydeoxyinosinic acid for 30 min at room temperature。 Nuclear protein-ODN complexes were r...
07-05-15摘要:Residues crucial to this action were previously identified in the last transmembrane helix of SUR, transmembrane helix 17。 Role of TM Helix 17 Aromatic Residues in KATP Channel Activation by Opene...
07-05-15摘要:Scorpion venoms contain peptides that block or modulate the activity of ion channels of excitable and nonexcitable cells (Miller, 1995。 Scorpions from the species A。 Results Isolation and Structu...
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