摘要：Cultures of Septal Cholinergic and LC Noradrenergic Neurons。 Septal cultures were prepared from embryonic day 15。 NA Rescues Cholinergic Neurons by Preventing Oxidative Stress。 Marien M, Briley ...

摘要：Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas Abstract In this issue of Molecular Pharmacology, Mukhopadhyay and Howlett present evidence for ligand-sele...

摘要：The former represented the glycosylated amino-terminal fragment, with the site of attachment further localized by endoproteinase Lys-C cleavage to the region between Asn10 and Lys37。 Among all app...

摘要：Taipoxin was purchased from Venom Supplies (Tanunda, South Australia)。 Results Effect of Taipoxin on Synaptic Boutons。 Taipoxin at nanomolar concentrations induces the formation of bulges on axon...

摘要：Lipogenic Gene Expression in Coordination with ER Stress Response。 Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, and Hotamisligil GS (2004) Endoplasmi...

摘要：) Abstract PDE4A11 is a novel cAMP-specific phosphodiesterase that is conserved in humans, mouse, rat, pig, and bat。 Reverse-transcriptase polymerase chain reaction performed across the splice jun...

摘要：Peroxisome proliferator-activated receptor (PPAR) seems to be a key component of lipid uptake by inducing the scavenger receptor CD36 that mediates oxidized low-density lipoprotein uptake in macrop...

摘要：Results Effect of Nucleotide Analogs on Photolabeling of MRP1 by [3H]LTC4。 References Beaudet L and Gros P (1995) Functional dissection of p-glycoprotein nucleotide-binding domains in chimeric and...

摘要：) Abstract Artemisinin drugs are of utmost importance in the treatment of malaria, because they represent the sole class of therapeutically used antimalarial drugs to which malaria parasites have n...

摘要：This constitutive activity of the receptor was abrogated by TAK779 (N,N-dimethyl-N-[4-[[[2-(4-methylphenyl)-6,7-dihydro-5H-benzocyclohepten-8-yl]carbonyl]amino]benzyl]tetrahydro-2H-pyran-4-aminium ...

摘要：Results TMPH Inhibition of Acetylcholine Receptor Subtypes。 Use Dependence of Inhibition by TMPH。 Progressive Inhibition of 42 Receptors by Repeated Coapplications of ACh and TMPH below Its IC50 ...

摘要：Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Zaragoza, Spain Abstract We have studied the mechanism of apoptosis elicited by the farnesy...

摘要：We have recently identified centaurin 1 as a GTPase activating protein (GAP) for ARF6。 The ADP-ribosylation factor (ARF) family of small GTPases has been implicated in the regulation of vesicle tr...

摘要：) Department of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands (P。) Abstract The intestinal absorption of the flavonoid quercetin in rats is limited by the secr...

摘要：Results nAChR Expression in the Striatum and Midbrain of 3 Genotypes。 References Azam L, Winzer-Serhan UH, Chen YL, and Leslie FM (2002) Expression of neuronal nicotinic acetylcholine receptor sub...

摘要：Chemically distinct ligands may allow this transition to progress by multiple pathways because of their differential ability to provide the activation energy for microisomerization to unique confor...

摘要：) Abstract Neurotensin (NT) is released in the gastrointestinal tract and participates in the pathophysiology of colonic inflammation。 Neurotensin (NT) is a 13 amino acid neuropeptide that is high...

摘要：Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota Abstract DNA methylation plays critical roles in gene-silencing through chromatin modification。 Chromatin immunoprecipit...

摘要：Nicotinic acetylcholine receptors (nAChRs) are ligandgated ion channels that have essential physiological roles in the central and peripheral nervous systems and are thought to be the primary media...

摘要：Endothelin-1-induced cell growth was blocked by the pharmacological Src antagonist 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2) but not by the inactive analog 4-amino-7-phe...

摘要：Proteins bound to the beads were eluted and separated by 10% SDS-polyacrylamide gel electrophoresis。 Hinz B and Brune K (2002) Cyclooxygenase-2eC10 years later。

摘要：Johnson Johnson Pharmaceutical Research and Development, LLC, San Diego, California Abstract Prokineticins 1 and 2 (PK1 and PK2) have been recently identified from humans and other mammals and pla...

摘要：Protein kinase C (PKC)-mediated phosphorylation of SERT occurs on the plasma membrane during the initial phase of rapid transporter inhibition, and later, the phosphorylated SERT enters the intrace...

摘要：Cells were then harvested, and luciferase assays were performed with the Dual Luciferase assay kit (Promega) as recommended by the manufacturer。

摘要：) Abstract CCAAT/enhancer-binding proteins (C/EBPs) are key transcription factors involved in the constitutive expression of several cytochrome P450 genes in the liver。 For instance, during inflam...

摘要：), Emory University School of Medicine, Atlanta, Georgia Abstract Gq family members (Gq, G11, G14, and G15/16) stimulate phospholipase C (PLC) and inositol lipid signaling but differ markedly in am...

摘要：Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas Abstract Neuron-restrictive silencer factor (NRSF) is a transcriptional repressor of multipl...

摘要：To examine the intracellular signaling pathways involved in this NR2B gene transcription, we have subjected fetal cortical neurons to long-term treatment with ethanol and studied its effect on cAMP...

摘要：Functional A1 and A3 subtypes are also present together with A2A and A2B in both neutrophils and lymphocytes (Gessi et al。 Feoktistov I and Biaggioni I (1998) Pharmacological characterization of a...

摘要：TristetraprolineC/eC mice develop a severe inflammatory phenotype because of an increased expression of pro-inflammatory cytokines such as TNF- and granulocyte/macrophage colony stimulating factor。...

摘要：Department of Biomedical Sciences, Iowa State University, Ames, Iowa Abstract In the presence of arginine vasopressin (AVP), somatostatin increases [Ca2+]i, leading to a transient increase in insul...

摘要：Department of Pharmacology, School of Medicine and Public Health, The Ohio State University, Columbus, Ohio Abstract Opioid receptors have been shown to dimerize or oligomerize among themselves and...

摘要：Results Identification of a Synthetic Human CRTH2 Receptor Ligand。 L-888,607 Is a Highly Selective Ligand for CRTH2。 L-888,607 Is a Potent Agonist at the Human Recombinant CRTH2 Receptor。 Gervai...

摘要：Voltage-Dependent Inhibition by Activation of mmGluR8a and rmGluR8b Receptors。 Kammermeier PJ and Ikeda SR (2002) Metabotropic glutamate receptor expression in the rat superior cervical ganglion。...

摘要：Department of Medicine and the Rebecca and John Moores Cancer Center, University of California, San Diego, La Jolla, California Abstract Replicative bypass of many DNA adducts is dependent on the i...

摘要：Inhibiting the expression of bcl-xL reduced the cytoprotective effect of CT。 Cell Culture and Treatment of Drugs。 Cells were seeded onto coverglasses in 24-well plates。 MTT Assay for Cell Viabil...

摘要：) Abstract The anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino-]carbonyloxycamptothecin (CPT-11) is a highly effective camptothecin analog that has been approved for the treatment of c...