摘要:Departments of Biochemistry Molecular Biology (B。J。P。, K。K。, T。A。T。, J。B。, L。M。O。, Y。A。H。) and Pathology and Laboratory Medicine (T。K。) Medical University of South Carolina, Char...
07-05-15摘要:Anthracyclines are potent antineoplastic agents used extensively to treat a range of cancers, including leukemias, lymphomas, sarcomas, and carcinomas (for review, see Gewirtz, 1999)。 Anthracyclin...
07-05-15摘要:Mixtures of arsenite plus benzo[a]pyrene (B[a]P) augment B[a]P mutagenicity, suggesting that arsenite might uncouple expression of phase I and II genes responsible for detoxification。 Global profi...
07-05-15摘要:) Abstract The most striking feature of a G protein-coupled receptor (GPCR) is its highly exclusive agonist specificity。 This feature guarantees that a GPCR recognizes only its specific native ago...
07-05-15摘要:The signals generated by GPCRs and RTKs were originally thought to be compartmentalized, with little or no cross-talk between receptors or sharing of their individual signaling pathways。 As noted ...
07-05-15摘要:[3H]Granisetron was obtained from PerkinElmer Life and Analytical Sciences, MDL 72222 from Sigma (St。 Malany S, Osaka H, Sine S, and Taylor P (2000) Orientation of -neurotoxin at the subunit inter...
07-05-15摘要:Department of Obstetrics Gynecology, Turku University Central Hospital, Turku, Finland (S。) Medicity Research Laboratory, University of Turku, Turku, Finland (R。) Joint Clinical Biochemistry Lab...
07-05-15摘要:FMO3 single nucleotide polymorphism (SNP) discovery was accomplished by resequencing DNA samples from the Coriell Polymorphism Discovery Resource。 For single nucleotide polymorphism (SNP) discover...
07-05-15摘要:Results Effect of Indole Derivatives on [3H]PGD2 Binding at Human CRTH2 Stably Expressed in HEK293 Cells。 Effect of Indole Derivatives on PGD2-Mediated CRTH2-Dependent Cellular Signaling Responses...
07-05-15摘要:), University of Pittsburgh, Pittsburgh, Pennsylvania Abstract Pregnane X receptor (PXR) is an orphan nuclear receptor that regulates the expression of genes encoding drug-metabolizing enzymes and ...
07-05-15摘要:) Abstract We investigated the effect of fluvastatin (Flv), an HMG-CoA reductase inhibitor, on Na+/Ca2+ exchanger 1 (NCX1) expression in H9c2 cardiomyoblasts。 Reverse transcriptase-polymerase chai...
07-05-15摘要:To investigate the intracellular signaling pathways activated by D-amphetamine and methylphenidate in the prefrontal cortex in vivo in mice, we measured the cAMP-dependent Ser845 phosphorylation of...
07-05-15摘要:In this issue of Molecular Pharmacology, the article titled “Single Nucleotide Polymorphisms in the Human Norepinephrine Transporter Gene Affect Expression, Trafficking, Antidepressant Interaction...
07-05-15摘要:Department of Pharmacology and Toxicology, Walther Oncology Center/Walther Cancer Institute and IU Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana Abstract ATP-binding c...
07-05-15摘要:), Columbus, Ohio Abstract Engagement of integrin cell adhesion receptors in mouse lung endothelial cells induces global sensitivity of DNA to nuclease digestion, reflecting alterations in chromati...
07-05-15摘要:Department of Pharmacological and Pharmaceutical Sciences, University of Houston, College of Pharmacy, Houston, Texas Abstract In this study, we investigate the molecular mechanisms by which acute ...
07-05-15摘要:Single-point mutations were generated using the QuikChange Site-Directed Mutagenesis Kit (Stratagene, La Jolla, CA) according to the manufacturer‘s instructions。 Structure, Function and Regulatio...
07-05-15摘要:Results Short- and Long-Term Effects of Morphine on Forskolin-Stimulated cAMP Production in Wild-Type and MOP Receptor-Overexpressing SH-SY5Y Clones。 Morphine was found to be far more potent and e...
07-05-15摘要:The 4(S252F) and 4(S256L) Mutations Obviously Alter Allosteric Ca2+ Activation。 The Effects of the 4(+L264), 2(V262M), and 2(V262L) Mutations Are More Complex。 Altered Allosteric Ca2+ Activation ...
07-05-15摘要:) Abstract Kahalalide F (KF) is a novel marine-derived antitumor agent that is currently undergoing phase II clinical trials。 The mechanism of action of KF is not well understood。 In line with pr...
07-05-15摘要:) Abstract The vitamin D Receptor (VDR) belongs to the superfamily of steroid/thyroid hormone receptors that is activated by 1,25-dihydroxyvitamin D3。 Discussion Vitamin D3 exerts a variety of bio...
07-05-15摘要:Rectification Properties of TRPM8。 Common Structure-Activity Relationships Defining the Ligand Recognition Properties of Human TRPM8 and TRPV1。 Significant Overlap in the Ligand-Recognition Prope...
07-05-15摘要:356) describe the agonist-stimulated formation of a caveolin-dependent signalplex that includes both the angiotensin AT1 receptor and the epidermal growth factor receptor, and probably also a numbe...
07-05-15摘要:The chemokine receptor CXCR2 has been shown to play a role in protecting neurons against -amyloideCinduced injury in vitro, but it remains unclear whether CXCR2-mediated neuroprotection is affected...
07-05-15摘要:Results DKHA Derivatives Specifically Target Mammalian Terminal Deoxyribonucleotidyl Transferases。 The DKHA Derivatives Are Noncompetitive Inhibitors of TDT。 The DKHA Derivatives RDS2119 and RDS2...
07-05-15摘要:) Abstract The farnesoid X receptor (FXR) is a nuclear receptor that functions as an endogenous sensor for bile acids (BAs)。 FXR is bound to and activated by bile acid, and chenodeoxycholic acid (...
07-05-15摘要:Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota Abstract The pharmacological effects of opioid drugs are mediated mainly by the e。opioid receptor (MOR), ...
07-05-15摘要:Nuclear extracts prepared according to Dignam et al。 Reversible Inhibition of NF-B DNA-Binding Activity by Diterpenoids。 Nuclear extracts were prepared and analyzed for NF-B activity by measuring...
07-05-15摘要:Inward rectification of Kir channels is distinct from the voltage dependence of Kv channels in that conductance is not a function of the absolute membrane potential。 Very Long Deca-Amines Indicate...
07-05-15摘要:Montreal Heart Institute and Department of Medicine (D。H。, A。M。, Z。W。, S。N。) Departments of Pharmacology (D。H。) and Physiology (M。S。, L。P。, R。S。), University of Montreal, Montreal, ...
07-05-15摘要:Vascular endothelial growth factor (VEGF) is an angiogenic protein that plays an important role in cellular homeostasis and is a key regulator of embryogenesis, the menstrual cycle, and wound repai...
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