摘要：Western blot analysis indicates that vincristine-selection is accompanied by down-regulation of topoisomerase II without detectable alterations of the other mitotic regulators studied, including Cd...

摘要：Besides the GPCR-induced GDP/GTP exchange, G-proteins of the Gi and Gs families can apparently be activated by the transfer of high energy phosphate onto GDP via nucleoside diphosphate kinase/G com...

摘要：) Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, West Virginia (B。) Abstract Apigenin is a natural dietary flavono...

摘要：) Abstract The CYP2C9。 To examine this possibility, the effect of the potent CYP2C9 inhibitor, benzbromarone, was studied with regard to CYP2C9。1- and CYP2C9。 Although benzbromarone inhibited CY...

摘要：The Thr139 amino acid is part of the so-called 7-8 loop, which comprises a six-amino acid motif denoted as SINNET。 Because of the close proximity of Thr139 and Glu138 in HIV-1 RT, it is plausible ...

摘要：College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea Abstract The CCAAT/enhancer-binding protein (C/EBP) -isoforms liver-enriched activator...

摘要：Thromboxane A2 (TXA2), a metabolite of arachidonic acid produced by cyclooxygenase and TXA2 synthetase, is known to induce many cellular responses, including platelet aggregation and contraction in...

摘要：Capsaicin and capsazepine (10-100 e) increase gA channel appearance rate and lifetime without measurably altering bilayer thickness or channel conductance, meaning that the changes in bilayer elast...

摘要：), Virginia Commonwealth University, Richmond, Virginia Abstract Human immunodeficiency virus (HIV) protease inhibitors have been successfully used in highly active antiretroviral therapy for HIV-1...

摘要：Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky Abstract Multidrug resistance-associated protein 2 (Mrp2, Abcc2), an organic anion transporter present in the apical memb...

摘要：Validation of the New Method。 Discussion Development of the Novel Assay。

摘要：Results Effect of GDP on Agonist-Induced Activation of Adenylyl Cyclase。 GDP-Mediated Adenylyl Cyclase Activation Does Not Result from Conversion to GTP。 Receptor Dependence of Cyclase Activation...

摘要：Long isoforms have such domains, called UCR1 and UCR2, whereas short isoforms have only UCR2 and supershort isoforms merely a truncated UCR2。 MacKenzie SJ, Baillie GS, McPhee I, MacKenzie C, Seamo...

摘要：Cloning of PCBP Family。 Results Cloning of Poly(C) Binding Protein Family。 PCBP Family Proteins Bind to the MOR Proximal Promoter In Vitro。 Specific Binding of PCBP Family Proteins to the MOR Pr...

摘要：) Abstract Nicotinic acetylcholine receptors (nAChRs) are decreased in the striata of patients with Parkinson‘s disease (PD) or in experimental models after nigrostriatal damage。 Because presynap...

摘要：CYP2C8 is an important member of the CYP2C subfamily, which metabolizes both endogenous compounds (i。 CYP2C8 is the most strongly inducible member of the CYP2C subfamily in human hepatocytes, but ...

摘要：National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina Abstract We investigated the acti...

摘要：), McGill University, Montreeal, Queebec, Canada Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B。 Davis Jewish General Hospital, Montreeal, Queeb...

摘要：Materials and Methods Substances。 Kokwaro JO (1976) Medicinal Plants of East Africa。

摘要：Norepinephrine and epinephrine act through three subtypes of -adrenoceptors (-AR) expressed in the adipocytes。 Norepinephrine, the neurotransmitter, and epinephrine, the hormone secreted by adrena...

摘要：In the present study, we investigated the role of breast cancer resistance protein (BCRP) in the biliary excretion of pitavastatin。 The ATP-dependent uptake of pitavastatin by human and mouse BCRP...

摘要：Dopamine receptor synergism could occur either at the level of neuronal networks through D1- and D2-like receptors expressed in separate neuronal populations or, on the other hand, within the same ...

摘要：Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique UPR2301, Gif-sur-Yvette, France Abstract The total CYP3A5 mRNA level is significantly greater in carriers ...

摘要：Bcl2 protein has been shown to lower cell sensitivity to chemotherapy and radiotherapy (Reed et al。 A further inspiration for these studies came from the discovery of an antisense RNA complementar...

摘要：Competition Binding Data with Chloroquine, Quinine, and Quinidine。 Chloroquine Blocks Native 910-Containing nAChRs of Rat Cochlear Inner Hair Cells。 Quinine is also used as a flavoring agent in t...

摘要：Vickers MF, Zhang J, Visser F, Tackaberry T, Robins MJ, Nielsen LP, Nowak I, Baldwin SA, Young JD, and Cass CE (2004) Uridine recognition motifs of human equilibrative nucleoside transporters 1 and...

摘要：Alanine scanning of putative pore regions of mouse RyR2 has highlighted the amino acid Gln4863, predicted to lie within trans-membrane helix TM10, as an important determinant of ryanodine binding。...

摘要：Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina Abstract PTEN (phosphatase with sequence homology to tensin) is a phosphatidylinositol 3,4,5-tr...

摘要：Institute of Cardiovascular Sciences, St。 Boniface General Hospital Research Centre and Department of Physiology (J。L。, J。G。, H。G。, P。W。, S。Z。) Division of Stroke and Vascular Disease, S...

摘要：Materials and Methods Isolation of Genomic BAC Subclones Containing Exon 5。 Identification and Characterization of Genomic BAC Subclones Containing the New Exon Sequence。 Four overlapping positiv...

摘要：Results Potentiation of the hERG Current by PD-118057 and Its Analogs。 Effect of PD-118057 on Action Potential Duration。 Potential therapeutic indications may include prevention and treatment of ...

摘要：Monitoring of the Interaction between IGF1R and PTP1B Using BRET Methodology。 Boute N, Pernet K, and Issad T (2001) Monitoring the activation state of the insulin receptor using bioluminescence re...

摘要：Effects of Mn-SOD Deficiency on Mitochondrial ALDH-2 Dehydrogenase, Esterase Activity, and Vascular ALDH Dehydrogenase Activity。 Heterozygous Mn-SOD Deficiency Does Not Affect NO-Signaling/Endothe...

摘要：Gallotannin and other tannins have been shown to exert various biological effects ranging from anti-inflammatory to anticancer and antiviral effects (Fong et al。 Expression Profiling with Low-Dens...

摘要：Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom Abstract Complement...

摘要：Molecular mechanisms of drug resistance in T。 Adenosine permeases turned out to play an important role in the uptake of, and resistance to, trypanocides。 Spectramax Gemini fluorimeter, Molecular ...

摘要：Vascular smooth muscle cells (VSMCs) alter their phenotype in response to vascular injury, or when propagated in tissue culture (Indolfi et al。 Cellular PDE4D expression is regulated transcription...

摘要：Menadione (K3), p-benzoquinone (BQ), histones, cysteine, N-acetyl cysteine (NAC), glutathione, iodoacetic acid (IAA), and trypan blue were all obtained from Sigma (St。 MEK1/2 Inhibition Prevents K...

摘要：) Abstract Folate cofactors are one-carbon donors essential for the biosynthesis of purines and thymidylate。 Analysis of hRFC Gene Copy Number by Semiquantitative Genomic PCR。 Establishment of a ...