摘要：【关键词】 sulfotransferase (SULT) *2。 In MCF-7 cells stably expressing either SULT1A1*1 or *2, the antiestrogenic response to OHT was found to be allele-specific: the cells expressing *2 exhi...

摘要： Hahn ME (2002) Aryl hydrocarbon receptors: diversity and evolution。[Abstract/Free Full Text] Williamson MA, Gasiewicz TA, and Opanashuk LA (2005) Aryl hydrocarbon recptor...

摘要：Phospholipase C activity was quantified 12 h after labeling by incubation in inositol-free DMEM containing 10 mM LiCl either in the absence of a receptor agonist or in the presence of 10 µ。 A...

摘要：Phosphatidylinositol 3-kinase (PI3K) inhibitors 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride (LY294002) and wortmannin also inhibited the potentiating action of US。 US stimulati...

摘要：【关键词】 Sulfonic Acid Groups P2X7。 The usefulness of NF110 as a P2X3 receptor antagonist in native tissues could be demonstrated by showing that NF110 blocks -methylene-ATP-induced currents...

摘要：Nuclear Protein Extract。 Nuclear protein extracts from pancreatic tissues were prepared as described previously (Rakonczay et al。 Nuclear protein from these same tissue samples was subjected to N...

摘要：【关键词】 Purinergic Agonists The interaction of mice submandibular gland cells with LL-37 (LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES), a cationic peptide with immunomodulatory properties, was inv...

摘要：【关键词】 Benz[e]indene 5 µ。M), BI-2 inhibits receptor function by enhancing the apparent rate of desensitization。 From single-channel recordings, we estimate that the entry rate into th...

摘要：Purification of Recombinant P450s 2S1 and 2W1。

摘要：【关键词】 Neurochemical Characterization The major contribution of this work is the isolation of a neuroprotective compound referred to as 2-amino-5-ureidopentanamide (FrPbAII) (Mr = 174) from...

摘要：【关键词】 Interaction In previous studies, we have demonstrated that the interaction of ryanoids with the sarcoplasmic reticulum Ca2+-release channel [ryanodine receptor (RyR)] incorporated in...

摘要：【关键词】 Arachidonic In the brain, arachidonic acid (AA) plays a critical role in the modulation of a broad spectrum of biological responses, including those underlying neuroinflammation。 By...

摘要：【关键词】 Calcitonin Receptors Calcitonin receptors (CTRs) dimerize with receptor activity-modifying proteins (RAMPs) to generate high-affinity amylin (AMY) receptors。 Receptor Binding。 The ...

摘要：【关键词】 Airways The NO/cGMP signaling pathway plays a major role in the cardiovascular system, in which it is involved in the regulation of smooth muscle tone and inhibition of platelet aggr...

摘要：【关键词】 Gene Hypoxia-inducible factor-1 (HIF-1) is a primary regulator of the physiological response to hypoxia。 A recombinant adenovirus expressing a constitutively active hybrid form of t...

摘要：Electrophysiology and Calcium Current Analysis。 Fluoxetine Inhibition of Recombinant T-Type Ca2+ Channels。[Abstract/Free Full Text] Triggle DJ (1992) Calcium-channel antagonists: mechanisms of...

摘要：【关键词】 Novel Potent Competitive Antagonist 7) (Badio and Daly, 1994。 2-Fluoro-3-(substituted phenyl)deschloroepibatidine analogs (Fig。 Structure of epibatidine (left) and 2-fluoro-3-(subst...

摘要：【关键词】 Suppression Oxidation of receptor protein tyrosine phosphatase- (RPTP) is emerging as an important yet poorly characterized regulatory mechanism for RPTP signaling in cells。 H2O2 In...

摘要：【关键词】 nigriventer Toxin A toxin was purified to homogeneity from the venom of the South American armed spider Phoneutria nigriventer and found to have a molecular mass of 8600 Da and a C-t...

摘要：Regulatory cis-elements mediating AHR activation of the CYP1A1 gene have been extensively studied, whereas those associated with regulation of the CYP1A2 gene are limited。 5‘-Flanking Region Nece...

摘要：【关键词】 Transactivation Transactivation of the rat apical sodium-dependent bile acid transporter (ASBT。 Slc10a2) by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] via the vitamin D receptor (VDR), ...

摘要：【关键词】 General Model Receptor Dimers Nonlinear Scatchard plots are often found for agonist binding to G-protein-coupled receptors。 Because there is clear evidence of receptor dimerization,...

摘要：【关键词】 Cytochrome P450 CYP3A4 The monotopic, endoplasmic reticulum (ER)-anchored cytochromes P450 (P450s) undergo variable proteolytic turnover。 CYP3A4, the dominant human liver drug-metab...

摘要：【关键词】 Implications for Drug Design Varicella zoster virus encodes a thymidine kinase responsible for the activation of antiherpetic nucleoside prodrugs such as acyclovir。Varicella zoster ...

摘要：【关键词】 Induction Renal cell carcinoma (RCC) is the most common malignancy of the kidney。 Cell death was associated with a decrease and increase in Bcl-xL and Bax expression, respectively, ...

摘要：In this study, by screening a chemical library composed of approximately 10,000 compounds, we identified a novel compound, 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amid...

摘要：【关键词】 Determination Dysiherbaine (DH) and related molecules are high-affinity, subunit-selective kainate receptor (KAR) ligands originally isolated from a marine sponge。 Binding of ligand...

摘要：【关键词】 Orazipone Orazipone is a novel sulfhydryl-reactive compound that has been previously shown to reduce lung eosinophilia in guinea pigs and rats and to inhibit degranulation in mast ce...

摘要：Phosphorylation of Smad1/5 Is Increased by Vitamin D3 Analogs in MCF10AT1 Breast Epithelial Cells。 Up-Regulation of BMP Signaling by the Vitamin D3 Analog Ro3582 Is Not Blocked by TGF--Neutralizin...

摘要：【关键词】 Suppression Regression Integrin 51 plays an important role in developmental angiogenesis, but its role in various types of pathologic neovascularization has not been completely defin...

摘要：【关键词】 Phosphatase Vascular endothelial growth factor (VEGF) plays a pivotal role in the pathogenesis of bronchial asthma。 Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) ha...

摘要：【关键词】 Short- Long-Term Regulation Activation of the opioid receptor results in short-term inhibition of intracellular cAMP levels followed by receptor desensitization and subsequent increa...

摘要：【关键词】 Development We have shown previously that an antitussive plant alkaloid, noscapine, binds tubulin, displays anticancer activity, and has a safe pharmacological profile in humans。 No...

摘要：【关键词】 IB Kinase-2-Independent Nuclear factor B (NF-B) is a transcription factor believed to be central in the expression of numerous inflammatory genes and the pathogenesis of many respira...

摘要：【关键词】 Inflammatory Mediators In the course of screening inhibitors of matrix metalloproteinase (MMP)-9 induction in macrophages, we isolated decursin, a coumarin compound, from the roots o...

摘要：【关键词】 Steroid Action Neuroactive steroids can either potentiate or inhibit a variety of membrane channels。 However, a recent study of the 1 (GABA-C) receptor (Mol Pharmacol 66:56-69, 2004...

摘要：【关键词】 Gene In this issue of Molecular Pharmacology, Luo et al。 HIF-1-Dependent Gene Expression。 Mol Genet Metab 71: 371-380。 Freedman SB and Isner JM (2001) Therap...