摘要:Apoptosis was characterized by chromatin condensation and fragmentation when examined by fluorescence microscopy。 (Ac)5GP Induces N-SMase Activation。 N-SMase Activation and NGF/p75 Interaction Me...
09-08-25摘要:【关键词】 Administration Long-term cannabinoid administration produces region-dependent CB1 receptor desensitization and down-regulation。 This study examined the time course for normalization...
09-08-25摘要:【关键词】 Hexachlorophene Aberrant activation of Wnt/-catenin signaling and subsequent up-regulation of -catenin response transcription (CRT) is a critical event in the development of human co...
09-08-25摘要:【关键词】 Characterization Nicotine‘s modulation of hippocampal noradrenergic neurotransmission may contribute to its mnemonic properties, but the nicotinic acetylcholine receptor (nAChR) sub...
09-08-25摘要:[3H]Epibatidine binding is distinctly biphasic。02 nM) and lower (Kd 5 nM) affinity sites in whole brains of wild-type mice are very similar。 Relative sensitivity to inhibition by cytisine or -bun...
09-08-25摘要:Determination of [14C]Pyruvate Accumulation。 Determination of Pyruvate Release。 Pyruvate was determined by the fluorometric method using NADH and lactate dehydrogenase。 Pyruvate was measured in ...
09-08-25摘要:Ghrelin stimulates expression and release of transmitters, especially from the NPY/AgRP neurons。 Ghrelin as well as various synthetic agonists for the ghrelin receptor will increase the signaling ...
09-08-25摘要:【关键词】 Cannabidiol-Induced In the current study, we examined the effects of the nonpsychoactive cannabinoid, cannabidiol, on the induction of apoptosis in leukemia cells。 Detection of Cann...
09-08-25摘要:【关键词】 Regulation Human organic anion transporter 3 (hOAT3/SLC22A8) is predominantly expressed in the proximal tubules of the kidney and plays a major role in the urinary excretion of a var...
09-08-25摘要:Adenylyl cyclases (ACs) catalyze the conversion of ATP to cAMP, a ubiquitous cellular second messenger that regulates a variety of cellular processes including gene transcription, enzyme regulation...
09-08-25摘要:【关键词】 Department Phospholipase C- (PLC-) isoenzymes are key effectors in G protein-coupled signaling pathways。 Phospholipase C (PLC) is a key effector enzyme in multiple cellular signalin...
09-08-25摘要:【关键词】 Purine Release The propagation of Ca2+ waves in a network of microglial cells, after its initiation by glutamate, is mediated by purinergic transmission。 Glutamate acting on AMPA re...
09-08-25摘要:【关键词】 organic cation/carnitine The organic cation/carnitine transporter OCTN2 is responsible for renal tubular reabsorption of its endogenous substrate, carnitine, although its physiologic...
09-08-25摘要:Mutagenesis of lysine at position 324 in helix 6 of the wild-type (WT) human 1-adrenergic receptor (1-AR) generated mutant receptors that had GTP-insensitive single low-affinity binding sites for a...
09-08-25摘要:【关键词】 N-Ethylmaleimide-Sensitive We have hypothesized that the plasma membrane protein components of the exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) rece...
09-08-25摘要:【关键词】 Varenicline Varenicline, a new nicotinic ligand based on the structure of cytisine, has recently been approved by the U。 Food and Drug Administration for use as a smoking cessation ...
09-08-25摘要:【关键词】 Functional Analysis Organic anion transporting polypeptide (OATP) superfamily member 2B1 (OATP2B1) mediates the uptake of steroid hormone precursors and selected drugs in the placent...
09-08-25摘要:【关键词】 Negative Regulation The role of thyroid hormone [L-3,5,3‘-triiodothyronine (T3)] and the thyroid hormone receptor (TR) in regulating growth, development, and metabolic homeostasis i...
09-08-25摘要:【关键词】 Pharmacological Obesity is now recognized as a rapidly increasing worldwide threat to health, largely as a result of causing diabetes。 Adipocytes at the center of metabolic regulati...
09-08-25摘要:【关键词】 Involvement The CB1 cannabinoid receptor has been implicated in the regulation of bone remodeling and bone mass。 A high bone mass (HBM) phenotype was reported in CB1-null mice gener...
09-08-25摘要:【关键词】 Naphthoquinone Derivative The 1,4-naphthoquinone derivative, shikonin, has been shown to increase glucose uptake by adipocytes and myocytes with minor effects on protein tyrosine pho...
09-08-25摘要:Protein expression in 1321N1 cells and platelets was determined by Western blotting。 Proteins were separated by SDS-PAGE。 Proteins were detected by ECL。 Protein kinase C-mediated phosphorylation...
09-08-25摘要:【关键词】 Bisindenoisoquinoline Indenoisoquinolines are topoisomerase (Top) I inhibitors developed to overcome some of the limitations of camptothecins and expand their anticancer spectrum。 B...
09-08-25摘要:【关键词】 Comparison Comparative protection studies in mice demonstrate that on a molar basis, recombinant human acetylcholinesterase (rHuAChE) confers higher levels of protection than native ...
09-08-25摘要:【关键词】 P-Glycoprotein In this work, we examined the ability of gp120, a human immunodeficiency virus-1 (HIV-1) viral envelope glycoprotein, to trigger the innate immune response in astrocyt...
09-08-25摘要:【关键词】 Dopamine We examined the ability of oxidation products of dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid (DOPAC) to inhibit proteasomal activity。 Dopamine, DOPA, and DOPAC under...
09-08-25摘要:【关键词】 Boswellic Acids Boswellic acids inhibit the transformation of arachidonic acid to leukotrienes via 5-lipoxygenase but can also enhance the liberation of arachidonic acid in human leu...
09-08-25摘要:【关键词】 Regulation Exposure to hepatitis C virus (HCV) can lead to the development of cirrhosis and hepatocellular carcinoma。 To examine the effects of long-term HCV infection on hepatic cy...
09-08-25摘要:We have demonstrated that the control of mitochondrial redox balance and oxidative damage is one of the primary functions of mitochondrial NADP+-dependent isocitrate dehydrogenase (IDPm)。 Oxidized...
09-08-25摘要:【关键词】 Differential 3-Phosphoinositide-dependent protein kinase-1 (PDK1) and Akt1 are two closely related components of the phosphatidylinositol-3 kinase (PI3K) pathway, which is aberrantly...
09-08-25摘要:【关键词】 5-Hydroxytryptamine-1A Numerous data showed that 5-hydroxytryptamine-1A (5-HT1A) receptors couple to Go/i proteins for signal transduction。 Immunoaffinity Chromatography Identificat...
09-08-25摘要:【关键词】 Apigenin Apigenin, one of the most common flavonoids, has been shown to possess anti-inflammatory, anticarcinogenic, and free radical-scavenging properties。 Apigenin, one of the mos...
09-08-25摘要:【关键词】 Functional Mapping Capsaicin (vanilloid) sensitivity has long served as the functional signature of a subset of nociceptive sensory neurons。 Functional studies with the capsaicin-in...
09-08-25