摘要:【关键词】 Regulator Axin, a negative regulator of the Wnt signaling pathway, contains a canonical regulator of G protein signaling (RGS) core domain。 Protein Purification。 Protein complexes ...
09-08-25摘要:【关键词】 Sazetidine-A Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels found throughout the central and peripheral nervous systems。 Sazetidine-A is a new nic...
09-08-25摘要:【关键词】 Ras-Dependent U1 bladder cancer cells of high malignancy exhibited higher proliferation capacity than U4 premalignant cells。 Higher expression of Ras, c-Myc, and nucleophosmin/B23 a...
09-08-25摘要:【关键词】 S-Nitrosylating The endogenous bronchodilator, S-nitrosoglutathione (GSNO), increases expression, maturation, and function of both the wild-type and the F508 mutant of the cystic fib...
09-08-25摘要:【关键词】 Inhibition Disturbances of endoplasmic reticulum (ER) Ca2+ homeostasis or protein processing can lead to ER stress-induced cell death。 To investigate the role of OS in ER stress, we...
09-08-25摘要:【关键词】 4-Hydroxytamoxifen 80%) (Jemal et al。 Furlanetto TW, Nguyen LQ, and Jameson JL (1999) Estradiol increases proliferation and down-regulates the sodium/iodide symporter gene in FRTL...
09-08-25摘要:Cloning of the Mouse R1 and R2 Subunits。 Cloning and Functional Assessment of the Mouse R1 and R2 Subunits。 A Single Amino Acid Substitution in Either R1 or R2 Results in Constitutive Activity。 ...
09-08-25摘要:【关键词】 4-Benzylpiperidine Motif In vivo screening of compounds for potential pharmacological activity is more advantageous than in vitro screening。 The compounds, termed JX401 and JX162, w...
09-08-25摘要:【关键词】 Contribution The goal of this study was to determine the ability of the major copper influx transporter CTR1 to mediate the cellular accumulation of cisplatin (DDP), carboplatin (CBD...
09-08-25摘要:【关键词】 Prevention Binding fibrinogen to activated glycoprotein (GP)IIb/IIIa is the final common pathway of platelet aggregation and has become a successful target for antiplatelet therapy。...
09-08-25摘要:【关键词】 Nicotinic Nicotinic acetylcholine receptors (AChRs) containing 6 subunits are typically found at aminergic nerve endings where they play important roles in nicotine addiction and Par...
09-08-25摘要:【关键词】 Role Studies using transient expression systems have implicated the hepatitis B virus X-associated protein (XAP2) in the control of aryl hydrocarbon receptor (AHR) stability and subc...
09-08-25摘要:【关键词】 Incorporation The &beta。 Human Neuronal Nicotinic Subunit cDNAs。 Subunits contained only coding sequences and an added Kozak consensus sequence (GCCACC) immediately upstream of the...
09-08-25摘要:【关键词】 (LXR)-β The nuclear receptors liver X receptor (LXR) LXR and LXR&beta。 However, these ligands may also increase hepatic triglyceride (TG) synthesis via a sterol response element bi...
09-08-25摘要:【关键词】 Focal Adhesion Kinase Focal adhesion kinase (FAK) is up-regulated in a variety of cancers, including breast cancer, in association with poor disease prognosis。Adhesion to the ECM is...
09-08-25摘要:【关键词】 Biophysical Within the field of new antiarrhythmic compounds, the interesting idea of activating human ether-a-go-go-related gene (HERG1) potassium channels has recently been introdu...
09-08-25摘要:【关键词】 Molecular Determinants Nicotinic receptors (acetylcholine receptors, AChRs) play key roles in synaptic transmission throughout the nervous system。 Activation of 7-5HT3A HC by Pyrant...
09-08-25摘要:In this study, we show that cannabinoid receptor type 1 (CB1) antagonist Rimonabant (SR141716) inhibited human breast cancer cell proliferation, being more effective in highly invasive metastatic M...
09-08-25摘要:【关键词】 Regulation Nicotinamide adenine dinucleotide (NAD) plays a critical role in the maintenance of cellular energy homeostasis。 -Amino-&beta。 -Amino-&beta。 Hepatic total RNA (10 µ。
09-08-25摘要:【关键词】 Endocrine Regulation Several examples of gender-divergent pharmacokinetics exist in humans and experimental animals, and one reason for these variations may be gender differences in ...
09-08-25摘要:Effect of OMT-Derivatives on tRNA Binding, Peptide-Bond Formation, and Peptidyl-tRNA Translocation。 Binding of OMT and OMT-Derivatives to Macrolide Resistant Ribosomes。
09-08-25摘要:【关键词】 Risperidone Risperidone displays a novel mechanism of antagonism of the h5-HT7 receptor。 Risperidone was one of the first of a new generation of antipsychotic drugs developed based ...
09-08-25摘要:【关键词】 Role The insecticide imidacloprid and structurally related neonicotinoids act selectively on insect nicotinic acetylcholine receptors (nAChRs)。 Neonicotinoids act selectively on ins...
09-08-25摘要:Spinal MAPK Involvement in Diabetes-Induced Hyperalgesia Expression of Phosphorylated Forms of MAPKs。 Influence of MAPK Inhibition on Diabetes-Induced Hyperalgesia。 Involvement of the NMDA Recept...
09-08-25摘要:Although it is assumed that this type of effect is mediated through CB1 receptor (CB1R) antagonism, several in vitro functional studies recently have suggested non-CB1R involvement。 We thoroughly ...
09-08-25摘要:In this study, we use high-resolution solution NMR to monitor changes in the chemical environment of the C-loop without and with acetylcholine (ACh) bound。 Solution NMR, on the other hand, maintai...
09-08-25摘要:【关键词】 Effects Regeneration of the chromophore 11-cis-retinal is essential for the generation of light-sensitive visual pigments in the vertebrate retina。 HPLC Analysis of Retinoids in the...
09-08-25摘要: Bauer B, Hartz AM, Fricker G, and Miller DS (2004) Pregnane X receptor up-regulation of p-glycoprotein expression and transport function at the blood-brain barrier。...
09-08-25摘要:【关键词】 Bioreduction We have previously evaluated the role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the bioreductive metabolism of 17-(allylamino)-demethoxygeldanamycin (17AAG) to the c...
09-08-25摘要:【关键词】 Binding Site Kv1。Atrial fibrillation represents a major clinical problem that can result in serious morbidity in elderly persons (Chugh et al。 (2001) Binding of correolide to the K...
09-08-25摘要:【关键词】 Antioxidant An alteration in the balance between a T-helper type 2 cell (Th2) response and a Th1 response may predispose to the development of bronchial asthma。 Interleukin-18 (IL-1...
09-08-25摘要:Adipocytes differentiation is a multistep process where fibroblast-like undifferentiated cells are converted into lipid droplets accumulating cells。 FXR Was Expressed on Adipose Tissue and Adipocy...
09-08-25摘要:【关键词】 Caveolin-1 associates Caveolin-1 associates with store-operated cation channels (SOC) in endothelial cells。 We used the cellpermeant antennapedia (AP)-conjugated CSD peptide, which ...
09-08-25摘要:【关键词】 ectodomain Lysine residues near each end of the receptor ectodomain (in rat P2X2 Lys69 and Lys308) have been implicated in ATP binding to P2X receptors。 We recorded membrane current...
09-08-25摘要:Transient receptor potential (TRP) channels have recently been reported to localize within caveolae, particularly the canonical TRPC1, TRPC3, and TRPC4 isoforms (Lockwich et al。[Abstract/Free Full...
09-08-25摘要:【关键词】 S-Nitrosylation Nitric-oxide synthases (NOS) are abundant in the respiratory epithelium and generate the NO radical, which can activate guanylate cyclase, react with superoxide, or m...
09-08-25