摘要：【关键词】 Methotrexate (MTX) Methotrexate (MTX) is the anticancer and antirheumatoid drug that is believed to block nucleotide synthesis and cell cycle by inhibiting dihydrofolate reductase ac...

摘要：【关键词】 Induction Nuclear factor-B (NF-B), a transcription factor with a critical role in promoting inflammation and cell survival, is constitutively activated in estrogen-receptor (ER)-nega...

摘要：【关键词】 Phosphodiesterase-5 Phosphodiesterase-5 (PDE5) contains a catalytic domain (C domain) that hydrolyzes cGMP and a regulatory domain (R domain) that contains two mammalian cGMP-binding...

摘要：【关键词】 Regulates The mechanism by which nerve growth factor (NGF) regulates adrenergic expression was examined in PC-12 cells transfected with a rat phenylethanolamine N-methyl-transferase ...

摘要：【关键词】 Monitoring In cells expressing both the insulin receptor isoform A (IRA) and the insulin-like growth factor-1 receptor (IGF1R), the presence of hybrid receptors, made up of an -IRA c...

摘要：【关键词】 Probing An increasing amount of ligand binding data on G protein-coupled receptors (GPCRs) is not compatible with the prediction of the simple mass action law。 FRET Experiments Prov...

摘要：【关键词】 Inhibitory Gating Modulation SK channels are small conductance Ca2+-activated K+ channels important for the control of neuronal excitability, the fine tuning of firing patterns, and ...

摘要：【关键词】 Voltage-Dependent Block Accumulating evidence indicates that dopamine and D1 receptor ligands modulate N-methyl D-aspartate (NMDA) receptors through a variety of D1 receptor-dependen...

摘要：【关键词】 Critical Role Receptor activity-modifying proteins (RAMPs) interact with and modify the behavior of the calcitonin receptor (CTR) and calcitonin receptor-like receptor (CLR)。 Intrac...

摘要：【关键词】 Cyclase Gene Deletion Affects Morphine Responses To define the roles of the calmodulin-stimulated adenylyl cyclases (AC1 and AC8) in morphine-induced analgesia, tolerance, physical d...

摘要：【关键词】 Modification The family of the organic anion transporting polypeptides forms an increasing group of uptake transport proteins with a wide substrate spectrum。 However, little is know...

摘要：【关键词】 Corticostriata We provide evidence that cocaine evokes short- and long-lasting increases in activity-regulated cytoskeletal-associated protein (Arc) expression after a finely tuned, ...

摘要：【关键词】 Involvement Tissue plasminogen activator (tPA), a serine protease, catalyzes the conversion of plasminogen to plasmin。 In the present study, we investigated the role of the tPA-plas...

摘要：【关键词】 Molecular Aspects The new platinum(IV) complex cis,trans,cis-[PtCl2(CH3COO)2-(NH3)(1-adamantylamine)] [adamplatin(IV)] seems promising for the perspective application in therapy of c...

摘要：【关键词】 Overexpression Overexpression of adenylyl cyclase (AC) has been proposed as a potential gene therapy strategy to increase cAMP formation in cardiomyocytes and cardiac function in viv...

摘要：【关键词】 Heterogeneity Nicotinic cholinergic receptors (nAChRs) are present in ganglia in the peripheral nervous system。 In autonomic ganglia, they are responsible for fast synaptic transmis...

摘要：【关键词】 Coactivator 1 Hepatocyte nuclear factor 4 (HNF4) is a key transcription factor for the constitutive expression of cytochromes P450 (P450s) in the liver。 Reporter assays with a chime...

摘要：【关键词】 Electron The aim of this study was to elucidate the vasodilating mechanism of sodium nitroprusside (SNP)。 Yonetani T, Tsuneshige A, Zhou Y, and Chen X (1998) Electron pa...

摘要：【关键词】 Plitidepsin Plitidepsin (aplidin) is a marine cyclic depsipeptide in phase II clinical development against several neoplasias。 Plitidepsin is a potent inducer of apoptosis through t...

摘要：【关键词】 Intersectin Receptor tyrosine kinases (RTKs) are critical for normal cell growth, differentiation, and development, but they contribute to various pathological conditions when disrup...

摘要：【关键词】 Oligodeoxynucleotides Cancer in general is a multifactorial process。 Targeting a single factor may not be optimal in therapy, because single agents are limited by incomplete efficac...

摘要：【关键词】 Comprehensive The recently elucidated crystal structure of a prokaryotic member of the neurotransmitter/sodium symporter (NSS) family (Yamashita et al。 To aid in the generalization ...

摘要：【关键词】 Tumor Growth Inhibition Hypoxia-inducible factor-1 (HIF-1), a transcription factor composed of HIF-1 and aryl hydrocarbon receptor nuclear translocator (ARNT), plays a key role in ce...

摘要：【关键词】 Functional C。 Genetic Analysis of SLC22A5。 Functional screen of protein-altering variants of OCTN2。 Amat di San Filippo C, Wang Y, and Longo N (2003) Function...

摘要：【关键词】 Cannabinoid We have recently shown that cannabinoids induce growth inhibition and apoptosis in mantle cell lymphoma (MCL), a malignant B-cell lymphoma that expresses high levels of c...

摘要：【关键词】 Salvicine Salvicine, a structurally modified diterpenoid quinone derived from Salvia prionitis, is a nonintercalative topoisomerase II (topo II) poison。 Salvicine (Fig。 Salvicine i...

摘要：【关键词】 Roles A novel trypanocide, 2,5-bis(4-amidinophenyl)furan (DB75), in its prodrug amidoxime-derivative form, 2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime (DB289), is in trials a...

摘要：Ligand Profiles on the 1 Adrenergic Receptor。 Ligand Profiles on the 2 Adrenergic Receptor。[Abstract/Free Full Text] Lavoie C, Mercier JF, Salahpour A, Umapathy D, Breit A, Villeneuve LR, Zhu ...

摘要：【关键词】 Transmembrane Domain VII Recent evidence implicating transmembrane (TM) segment 7 of the apical sodium-dependent bile acid transporter (ASBT) in substrate interaction warranted exami...

摘要：【关键词】 Synergistic Effects Previous studies on the drug content of pelleted tubulin polymers suggest that peloruside A binds in the laulimalide site, which is distinct from the taxoid site。...

摘要：【关键词】 Concerted Contribution Gating of voltage-gated K+ channels (Kv channels) depends on the electromechanical coupling between the voltage sensor and activation gate。 Structural Analysi...

摘要：【关键词】 Trastuzumab Although trastuzumab has been successfully used in patients with HER2-overexpressing metastatic breast cancer, resistance is a common problem that ultimately culminates i...

摘要：【关键词】 Inhibition The peroxisome proliferator-activated receptor (PPAR), a member of the nuclear hormone receptor family, represents a possible new target in glioma therapy。 Glioma cells s...

摘要：【关键词】 Mibefradil Mibefradil is a tetralol derivative once marketed to treat hyper-tension。 Its primary target is the T-type Ca2+ channel (IC50, 0。M), but it also blocks Na+,K+,Cl-, and o...

摘要：【关键词】 A Three-Dimensional Based on the topoisomerase II catalytic inhibitory activity of a previous hit compound, NSC35866, we screened 40 substituted purines or purine-like compounds from...

摘要：【关键词】 Enhancement The slow afterhyperpolarization (sAHP) in hippocampal neurons has been implicated in learning and memory。 Hippocampal Cell Culture Hippocampal pyramidal neurons were cul...

摘要：【关键词】 Circumventing Delivery of multiple exogenous genes into target cells is important for a broad range of gene therapy applications, including combined therapeutic gene expression and n...

摘要：Calpain is involved in regulating many cellular processes, including proliferation, differentiation, cell motility, and metastasis through regulation of signal transduction and cleavage of many tar...

摘要：【关键词】 HIF-1 Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional induction of a series of genes that participate in angiogenesis, iron metabolism, g...