摘要:【关键词】 Human In a previous study, we demonstrated that the sugar conformation and helical geometry of the heteroduplex substrate at the catalytic site of human RNase H1 directs the selectiv...
09-08-25摘要:Comparison of Mouse and Rat P2X7 Receptors。 Introducing Single Amino Acids of Rat P2X7R into Mouse P2X7R。
09-08-25摘要:【关键词】 Positional Influence In a companion study published in this issue (p。 83), we showed that chimeric substrates containing 2‘-methoxyethyl (MOE) nucleotides inhibited human RNase H1 ...
09-08-25摘要:【关键词】 c-Abl Curcumin, a natural phenolic compound found in turmeric (Curcuma longa) exhibits anticancer properties, attributed to its antiproliferative and apoptosis-inducing activity。 Th...
09-08-25摘要:【关键词】 Response In response to the comments by Dr。 Calpain-catalyzed proteolysis is typically limited, resulting in a clipped but substantially intact protein, and Suzuki et al。 ...
09-08-25摘要:【关键词】 Characterization Dephosphorylation of the cyclic AMP-dependent protein kinase (PKA) site phosphoserine 262 and the G protein-coupled receptor kinase (GRK) site phosphoserines 355 and...
09-08-25摘要:【关键词】 Structural The imidazopyridine zolpidem (Ambien) is one of the most commonly prescribed sleep aids in the United States (Rush, 1998)。 Similar to classic benzodiazepines (BZDs), zolp...
09-08-25摘要:【关键词】 Comments Dale and Eltom (2006) suggest that activation of the aryl hydrocarbon receptor (AHR)-signal transduction pathway is initiated after proteolytic processing of the AHR by calp...
09-08-25摘要:【关键词】 Translational Multidrug resistance-associated protein 2 (Mrp2/Abcc2), an organic anion transporter present in the apical membrane of hepatocytes, renal epithelial cells, and enterocy...
09-08-25摘要:【关键词】 Cystic Fibrosis According to previous reports, flavonoids and nutraceuticals correct defective electrolyte transport in cystic fibrosis (CF) airways。 We examined herbal extracts of ...
09-08-25摘要:【关键词】 Reversion The presence of cis-configured exchangeable ligands has long been considered a prerequisite for antitumor activity of platinum complexes, but over the past few years, sever...
09-08-25摘要:The Zol effects on proliferation were due to cell cycle arrest in S and G2/M phases subsequent to the activation of the intra-S DNA damage checkpoint with an increase in P-ATR, P-chk1, Wee1, and P-...
09-08-25摘要:【关键词】 Geldanamycin We have demonstrated that lipopolysaccharide (LPS)-mediated reactive oxygen species (ROS) and signal transduction are involved in the regulation of interleukin-1 (IL-1) ...
09-08-25摘要:The role of RasGRP1, a PMA-activated guanine nucleotide exchange factor for Ras, in EL4 phenotype was examined。 Endogenous RasGRP1 protein is expressed at much higher levels in sensitive than in r...
09-08-25摘要:We report herein the screenings of nonamidated and acetylated hexapeptide PS-SPCLs for PC5/6A and PC7。 Inhibitory potency of these polybasic peptides increased with chain length, making nona-L-Arg...
09-08-25摘要:【关键词】 Phosphorylation Agonist treatment causes desensitization of many G proteincoupled receptor systems。 Immunoprecipitation of Gq/11 Proteins。 Protein concentrations were measured usin...
09-08-25摘要:【关键词】 Pyrrolidine Pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear transcription factor -B (NF-B) and an antioxidant, has beneficial effects in animal models of various diseases...
09-08-25摘要:Antimicrob Agents Chemother 34: 134-138。 Antimicrob Agents Chemother 48: 3858-3870。 Antimicrob Agents Chemother 49: 4721-4732。 Antimicrob Agents Chemother 49: 3607-3615。
09-08-25摘要:【关键词】 Neurokinin 1 Neurokinin (NK) 1 receptors and CaV2。 Neurokinin A (NKA), substance P, pertussis toxin (PTX), cholera toxin (CTX), staurosporine, bisindolylmaleimide (Bis) I, and Bis V...
09-08-25摘要:【关键词】 Characterization L-Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system。 Characterization of these compounds in the binding assay developed her...
09-08-25摘要:【关键词】 Molecular Basis The aim of the present study was to challenge potential mechanisms of action underlying the inhibition of tumor cell proliferation by agmatine。 Antiproliferative Eff...
09-08-25摘要:【关键词】 Human The impact of human chorionic gonadotropin (hCG) on prostate carcinoma viability was investigated。 Exposure of LNCaP cells to hCG promoted activation of epidermal growth facto...
09-08-25摘要:【关键词】 Cellular The epithelial barrier is determined primarily by intercellular tight junctions (TJs)。 Retinoic acid (RA) is a biologically active regulator that has a broad range of funct...
09-08-25摘要:【关键词】 Effect Some cellular uptake systems for (anti)folates function optimally at acidic pH。 ABCG2), which has been reported to transport folic acid, methotrexate, and methotrexate di- an...
09-08-25摘要:【关键词】 Amphetamine Norepinephrine (NE) transporters (NETs) are high-affinity transport proteins that mediate the synaptic clearance of NE after vesicular release。 Single-Cell Calcium Deter...
09-08-25摘要:【关键词】 Sulforaphane (SFN) Sulforaphane (SFN) is a biologically active phytochemical found abundantly in broccoli。 Sulforaphane (SFN) is one of the most biologically active phytochemicals i...
09-08-25摘要:【关键词】 Repression Down-regulation of glutathione transferase A1 (GSTA1) expression has profound implications in cytoprotection against toxic by-products of lipid peroxidation produced durin...
09-08-25摘要:【关键词】 X Chromosome-Linked Identifying the active chemical ingredients of ancient medicines and the molecular targets of those ingredients is an attractive therapeutic objective。 Embelin, ...
09-08-25摘要:【关键词】 Responsiveness mouse。 Ezetimibe analogs that bind to NPC1L1 exhibit in vivo cholesterol-lowering activity, whereas compounds that do not bind NPC1L1 are inactive。 Specific structur...
09-08-25摘要:【关键词】 oxygenase-1 Heme oxygenase-1 (HO1), which oxidizes heme to biliverdin, CO, and free iron, conveys protection against oxidative stress and is antiapoptotic。 Motexafin gadolinium (MGd...
09-08-25摘要:We now report that the caulibugulones are selective in vitro inhibitors of the Cdc25 family of cell cycle-controlling protein phosphatases compared with either human vaccinia H1-related phosphatase...
09-08-25摘要:【关键词】 Regulation Cyclic nucleotide-gated (CNG) channels are critical components of the vertebrate visual transduction cascade involved in converting light-induced changes in intracellular ...
09-08-25摘要:【关键词】 Silico Prediction Pregnane X receptor (PXR) regulates drug metabolism and is involved in drug-drug interactions。 Prediction of PXR activators is important for evaluating drug metabo...
09-08-25摘要:【关键词】 Identification Regulators of G-protein signaling (RGS) proteins are important components of signal transduction pathways initiated through G-protein-coupled receptors (GPCRs)。 The a...
09-08-25摘要:【关键词】 Role We have demonstrated previously that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) up-regulates Fas and FasL in immune cells, although the molecular mechanisms remain unknown。 Rol...
09-08-25摘要:【关键词】 Interaction There is increasing evidence that the signal transduction of opioid receptors is modulated by receptor-associated proteins。-opioid receptor (MOPr) endocytosis, synaptoph...
09-08-25摘要:[Abstract/Free Full Text] Sutherland RL, Prall OW, Watts CK, and Musgrove EA (1998) Estrogen and progestin regulation of cell cycle progression。 (2003) Estrogen receptor-alpha mediates the brai...
09-08-25摘要:Activation of opioid receptors modulates voltage-gated ion channels, but it is unclear whether opioids can also influence ligand-gated ion channels [e。-Receptors in DRG。 Opioids Inhibit Capsaicin...
09-08-25摘要:【关键词】 N-Methyl-D-aspartate N-Methyl-D-aspartate receptors (NMDARs) composed of NR1 and NR3 subunits differ from other NMDAR subtypes in that they require glycine alone for activation。 How...
09-08-25摘要:【关键词】 Down-Regulation The identification of differentially regulated apoptotic signals in normal and tumor cells allows the development of cancer cell-selective therapies。 Down-Regulation...
09-08-25