摘要：【关键词】 Role Kinin B1 receptor expression was characterized in human umbilical artery smooth muscle cells to further elucidate the function and specificity of three previously proposed pathw...

摘要：【关键词】 HIF-1 HIF-1 not only enables cells to survive under hypoxic conditions but also promotes cell cycle arrest and apoptosis。 We recently reported that bafilomycin A1 exorbitantly expre...

摘要：【关键词】 Molecular Trypanosoma brucei encodes a relatively high number of genes of the equilibrative nucleoside transporter (ENT) family。 Molecular Cloning of Additional Members of the ENT F...

摘要：【关键词】 Activation Seven transmembrane segment (7TM) receptors are activated through a common, still rather unclear molecular mechanism by a variety of chemical messengers ranging from monoa...

摘要：【关键词】 Essential The laser confocal fluorescent microscope-based observation of contractile responses in green fluorescent protein-expressing differentiated vascular smooth muscle cells, co...

摘要：【关键词】 Probing HIV-1 integrase binds site-specifically to the ends of the viral cDNA。 We used two HIV-1 integrase-DNA cross-linking assays to probe the binding sites of integrase inhibitor...

摘要：【关键词】 Neurokinin-3 Talnetant and osanetant, two structurally diverse antagonists of neurokinin-3 receptor (NK3), displayed distinct modes of action in Ca2+ mobilization。 Similar patterns ...

摘要：【关键词】 4-Hydroxy-2-nonenal 4-Hydroxy-2-nonenal (4-HNE) is a major lipid peroxidation (LPO) product formed during oxidative stress。 Recent evidence suggests that chronic prooxidant exposure...

摘要：Effects of aliphatic VPA constitutional isomers on rat DRGs growth cone spreading。 Effects of VPA and aliphatic VPD constitutional isomers on rat DRGs growth cones spreading。 Effects of VPA analo...

摘要：【关键词】 Up-Regulation Induction of apoptosis by nonsteroidal anti-inflammatory drugs, such as celecoxib, is involved in their antitumor activity。 An endoplasmic reticulum chaperone, 150-kDa...

摘要：【关键词】 Identification Barbiturates were introduced into medical practice in 1934。 Siegwart R, Jurd R, and Rudolph U (2002) Molecular determinants for the action of ge...

摘要：【关键词】 MCF-7 In the present study, we investigated the effect of the antiestrogen compound tamoxifen on BK channels by the use of the patch-clamp technique。 The perfusion of 10 nM tamoxife...

摘要：【关键词】 Characterization DBA/2 and C57BL/6 are two commonly used mouse strains that differ in response to nicotine。 Nicotine was metabolized to cotinine in vitro by two enzymatic sites。7 &...

摘要：【关键词】 Dopamine The primary mechanism for clearance of extracellular dopamine (DA) is uptake mediated by the dopamine transporter (DAT), which is governed, in part, by the number of functio...

摘要：【关键词】 Hepatic Hepatic ischemia-reperfusion (IR) results in Kupffer cell activation and subsequent tumor necrosis factor (TNF) release, leading to localized hepatic injury and remote organ ...

摘要：【关键词】 Transcriptional CYP2A13, which is highly active in the metabolic activation of tobacco-specific nitrosamines, is selectively expressed in the respiratory tract, in which it is believ...

摘要：【关键词】 Pioglitazone Thiazolidinediones (TZDs) such as pioglitazone and rosiglitazone are widely used as insulin sensitizers in the treatment of type 2 diabetes。 We studied the regulation o...

摘要：【关键词】 Evidence Multiple stimuli of physiological and pathophysiological significance, including 1-adrenoceptor agonists, stimulate the cardiac sarcolemmal Na+/H+ exchanger isoform 1 (NHE1)...

摘要：【关键词】 Novel The 7 nicotinic acetylcholine receptor subunit (CHRNA7) gene harbors a high degree of polymorphism。 Single-stranded fragments were separated by electrophoresis on Mutation Det...

摘要：【关键词】 Mutational The 2nd outer loop (o2) of muscarinic acetylcholine receptors (mAChRs) contains a highly conserved cysteine residue that is believed to participate in a disulfide bond and...

摘要：【关键词】 Ca2+ Human 42 nicotinic acetylcholine receptors (AChRs) expressed in Xenopus laevis oocytes or transfected cell lines are present as a mixture of two stoichiometries, (4)2(2)3 and (4...

摘要：【关键词】 Modulating Cystic fibrosis transmembrane conductance regulator (CFTR) and P-glycoprotein (P-gp) are ATP-binding cassette (ABC) transporters that have two transmembrane domains (TMDs)...

摘要：【关键词】 Benzo[a]pyrene-7 Polycyclic aromatic hydrocarbons (PAHs) are potent carcinogens that require metabolic activation inside cells。 We assessed the effect of benzo[a]pyrene-7,8-dihydrod...

摘要：【关键词】 Reactive Malonate, an inhibitor of mitochondrial complex II, is a widely used toxin to study neurodegeneration in Huntington‘s disease and ischemic stroke。 Detection of Peroxides/R...

摘要：【关键词】 Identification Sphingosine-1-phosphate (S1P) receptor agonists are novel immunosuppressive agents。 The models predict that S1P1 Leu276 and S1P3 Phe263 contribute to the S1P1/S1P3 se...

摘要：【关键词】 Analysis Carboxylesterases (CE) are ubiquitous enzymes that hydrolyze numerous ester-containing xenobiotics, including complex molecules, such as the anticancer drugs irinotecan (CPT...

摘要：【关键词】 Nucleotide Cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine。 Cidofovir also possesses potent activity against human papillomavirus-induced tumors in animal models and ...

摘要：【关键词】 Amino-Pyrrolidine Like most class C G-protein-coupled receptors, metabotropic glutamate (mGlu) receptors possess a large extracellular domain where orthosteric ligands bind。 Nucleic...

摘要：【关键词】 Protease-Activated Pathological conditions such as coronary artery disease are clinically controlled via therapeutic regulation of platelet activity。 Thrombin, through protease-acti...

摘要：【关键词】 μ-Conotoxin µ。-Conotoxins are three-loop peptides produced by cone snails to inhibit voltage-gated sodium channels during prey capture。-conotoxin-TIIIA (TIIIA)。 A 125I-TIIIA...

摘要：【关键词】 Tumor The ATP-driven drug efflux pump, P-glycoprotein, is a critical and selective element of the blood-brain barrier and a primary impediment to pharmacotherapy of central nervous s...

摘要：【关键词】 Inhibition We tested and characterized the therapeutic value of round window membrane-delivered (RWM) D-JNKI-1 peptide (Bonny et al。 Analysis of the events occurring after sound tra...

摘要：【关键词】 Native Previous studies have shown that human 5-hydroxytryptamine (5-HT)1A receptors stably expressed in transfected cell lines show constitutive G-protein activity, as revealed by t...

摘要：【关键词】 DNA Reelin and glutamic acid decarboxylase 67 (GAD67) mRNAs and protein levels are substantially reduced in postmortem brains of patients with schizophrenia。 To explore whether huma...

摘要：【关键词】 DNA In this issue of Molecular Pharmacology, Kundakovic et al。 The regulation occurs at the level of DNA (cytosine-5) methylation。 Moreover, the authors present evidence suggesting...