摘要：【关键词】 Pioglitazone Lung cancer cells elaborate the immunosuppressive and antiapoptotic mediator prostaglandin E2 (PGE2), a product of cyclooxygenase-2 (COX-2) enzyme activity。 Pioglitazon...

摘要：【关键词】 Fisetin Fisetin (3,7,3‘,4‘-tetrahydroxyflavone) exhibits anti-inflammatory and antiproliferative effects through a mechanism that is poorly understood。 Fisetin also suppressed the...

摘要：【关键词】 Thiazolidinedione Thiazolidinediones alter cell energy metabolism。 Pioglitazone treatment was also associated with increased cytoplasmic but reduced mitochondrial peroxide levels。 ...

摘要：【关键词】 Amine-Containing Many amines are skin irritants and cause contact dermatitis。 Irritant contact dermatitis is an innate inflammatory cutaneous overreaction to corrosive chemicals app...

摘要：【关键词】 Quercetin We investigated a molecular mechanism underlying quercetin-mediated amelioration of colonic mucosal injury and analyzed chemical structure contributing to the quercetin‘s ...

摘要：【关键词】 Gq-Mediated The TASK subfamily of two pore domain potassium channels (K2P) gives rise to leak potassium currents, which contribute to the resting membrane potential of many neurons a...

摘要：【关键词】 Inhibition The cyclopeptolide CAM741 inhibits cotranslational translocation of vascular cell adhesion molecule 1 (VCAM1), which is dependent on its signal peptide。 Structures of CAM...

摘要：【关键词】 Subunit-Stoichiometric ATP-sensitive K+ channels are gated by intracellular ATP, allowing them to couple intermediary metabolism to cellular excitability, whereas the gating mechanis...

摘要：【关键词】 Inhibition We previously developed a gene-gun-based in vivo screening system and identified shikonin as a potent suppressor of tumor necrosis factor- (TNF-) gene expression。[CrossRe...

摘要：Relaxin-3 is the most recently identified member of this family of peptides, with the highest mRNA expression in the brain, in the neurons of the nucleus incertus (NI) (Bathgate et al。 Receptor Co...

摘要：【关键词】 Identification Both transcriptional and post-transcriptional CYP2E1 regulatory mechanisms are known, resulting in 20-fold or greater variation in CYP2E1 expression。 DNA Sequence Ana...

摘要：【关键词】 Kinetics Controlled inhibition of brain acetyl- and butyrylcholinesterases (AChE and BChE, respectively) and of monoamine oxidase-B (MAO-B) may slow neurodegeneration in Alzheimer‘s...

摘要：【关键词】 Involvement Continuous ingestion of phencyclidine (PCP) in humans produces long-lasting schizophrenic-like cognitive dysfunction。) for 14 days displayed an impairment of latent lear...

摘要：【关键词】 Natural Enantiomeric We have studied the ability of the androgen etiocholanolone and its enantiomer (ent-etiocholanolone) to modulate rat 122L GABAA receptor function transiently exp...

摘要：【关键词】 Involvement The purpose of the present study was to investigate the role of multidrug resistance-associated protein 4 (MRP4) in the tubular secretion of cephalosporin antibiotics。 M...

摘要：【关键词】 Pharmacology Subtypes of nicotinic acetylcholine receptors (nAChR) containing 6 subunits comprise 25 to 30% of the presynaptic nAChRs expressed in striatal dopaminergic terminals in ...

摘要：【关键词】 Adrenergic norepinephrine phenylephrine。 Hillman KL, Doze VA, and Porter JE (2005a) Adrenergic receptor characterization of CA1 hippocampal neurons using real time sing...

摘要：【关键词】 Phosphatase Peroxisome proliferator-activated receptor- (PPAR) activation enhances insulin sensitivity in type 2 diabetes mellitus。

摘要：【关键词】 Selective Terpenoids constitute a large family of natural steroids that are widely distributed in plants and insects。 Activation of LXR by these diterpenes was evaluated in transien...

摘要：【关键词】 Mechanism Thiazolidinediones are synthetic agonists for the transcription factor peroxisome proliferator-activated receptor (PPAR) and are therapeutically used as insulin sensitizers...

摘要：【关键词】 Proteasome-Regulated A major challenge to broadening oncology applications for inhibitors of the ubiquitin-proteasome system (UPS) is the identification of UPS-dependent cancer pathw...

摘要：【关键词】 Mutation 200-fold。60A mutant compared with WT human CB1 receptors。60, plays a crucial role in mediating ligand specific interactions for CP55,940, HU210, and AM4056 at the human CB1...

摘要：【关键词】 Chromanol The chromanol 293B (293B, trans-6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethyl-chroman) is a lead compound of potential class III antiarrhythmics that inh...

摘要：【关键词】 Interaction Endothelin-1 (ET-1) regulates contractility and growth of the mammalian heart by binding endothelin receptor type A (ETA) and endothelin receptor type B (ETB) G-protein-c...

摘要：【关键词】 Induction Expression of Cyp1a1 and its related enzyme activity have long been used as a biomarker for aryl hydrocarbon receptor (AhR) activation and a warning of dioxin-like toxicity...

摘要：【关键词】 Identification Multidrug and toxin extrusion 1 (MATE1) has been isolated as an H+/organic cation antiporter located at the renal brush-border membranes。 Transport Analysis of rMATE1...

摘要：【关键词】 Modified Serotonin 5-HT2B receptors are often coexpressed with 5-HT1B receptors, and cross-talk between the two receptors has been reported in various cell types。 However, many mech...

摘要：【关键词】 Rimonabant The advent of the highly selective cannabinoid receptor (CB1) antagonist, rimonabant (SR141716。 Rimonabant potency as an antagonist has been shown by comparing its abilit...

摘要：【关键词】 Induction The nuclear factor of activated T cell cytoplasmic 1 (NFATc1) is a member of the NFAT family and is strictly implicated in the growth and development of bone。 Activation o...