摘要：【关键词】 Small-Molecule G-protein-coupled receptors (GPCRs) such as the vasopressin-2 receptor (V2R) are an important class of drug targets。 Receptor Binding Assay。 V2Rinh-02 Is a Competiti...

摘要：【关键词】 Chronic A chronic intermittent ethanol (CIE) exposure regimen consists of repeated episodes of ethanol intoxication and withdrawal。 Chronic intermittent ethanol (CIE) exposure regim...

摘要：【关键词】 Characterization Within the family of serotonin receptors, the 5-hydroxytryptamine-3 (5-HT3) receptor is the only ligand-gated ion channel。 5-HT3C, 5-HT3D, 5-HT3E, and 5-HT3Ea Const...

摘要：Vasoactive intestinal peptide (VIP), a neuropeptide, may act as a survival factor for prostate cancer cells under androgen deprivation。 However, the molecular mechanisms by which VIP promotes the ...

摘要：【关键词】 Antidiabetes Metabolic disorders, including type 2 diabetes and obesity, represent major health risks in industrialized countries。 Cryptotanshinone was originally isolated from the ...

摘要：【关键词】 Nigrostriatal Parkinson‘s disease is a neurodegenerative movement disorder characterized by a loss of substantia nigra dopamine neurons, and corresponding declines in molecular comp...

摘要：【关键词】 Glycogen Emerging evidence has suggested that glycogen synthase kinase 3 (GSK-3) is a key regulatory kinase involved in a plethora of processes in the nervous system, including neuro...

摘要：【关键词】 Evidence Autophagy is a response of cancer cells to various anticancer therapies。 Curcumin induced G2/M arrest and nonapoptotic autophagic cell death in both cell types。 Malignant ...

摘要：【关键词】 Structure-Activity Mutations occurring in the CFTR gene, encoding for the cystic fibrosis transmembrane conductance regulator chloride channel, cause cystic fibrosis (CF)。 Potentiat...

摘要：【关键词】 Serotonin The entorhinal cortex (EC) is regarded as the gateway to the hippocampus。 Serotonin-mediated inhibition of EC activity resulted in an inhibition of hippocampal function。 ...

摘要：【关键词】 Bioactivation Bioactivation of nitroglycerin (GTN) into an activator of soluble guanylate cyclase (sGC) is essential for the vasorelaxant effect of the drug。 Besides several enzymes...

摘要：【关键词】 Activation The role of transmembrane domain six (TMD6) of the angiotensin II type 1 receptor, which is predicted to undergo conformational changes after agonist binding, was investig...

摘要：【关键词】 Small-Molecule A panel of four CCR5 monoclonal antibodies (mAbs) recognizing different epitopes on CCR5 was examined in CCR5-mediated cell-cell fusion assay, alone or in combination ...

摘要：【关键词】 Regulation Whereas the liver as well as the other organs are continually exposed to the change of osmotic status, it has never been investigated whether activities and gene expressio...

摘要：【关键词】 Hypoxia Solid tumors contain hypoxic cells that are resistant to radiotherapy and chemotherapy。 In this study, we found that in human glioblastoma cells hypoxia induces the phosphor...

摘要：【关键词】 Inhibition Transforming growth factor (TGF) is a pleiotropic factor that regulates cell proliferation, angiogenesis, metastasis, and immune suppression。 Pancreatic cancer is the fif...

摘要：【关键词】 Identification We studied the mechanism of action of 3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid ethyl ester (JG-03-14) and found that it is a potent microtubule...

摘要：【关键词】 Cholesterol-Like Strong evidence suggests a mechanistic link between cholesterol metabolism and the formation of amyloid- peptides, the principal constituents of senile plaques found...

摘要：【关键词】 Site-Specific Glomerulonephritis represents a group of renal diseases with glomerular inflammation as a common pathologic finding。 Induction of Accelerated Anti-GBM Glomerulonephrit...

摘要：【关键词】 Differential Pituitary adenylate cyclase-activating polypeptide (PACAP), a pleiotropic neuropeptide, performs a variety of physiological functions。 The actions of PACAP are mediated...

摘要：【关键词】 Adrenomedullin Adrenomedullin (ADM) in the brain plays important roles in the maintenance of homeostasis。 Adrenomedullin (ADM), a 52 amino acid peptide, was first isolated from huma...

摘要：【关键词】 pharmacological Small molecules are powerful pharmacological tools to dissect biological events。 Screening a small library, such as the Library of Pharmacologically Active Compounds...