摘要:【关键词】 Multikinase The effects of the multikinase inhibitor sorafenib (BAY 43-9006), an agent shown previously to induce apoptosis in human leukemia cells through inhibition of myeloid cell...
09-08-25摘要:【关键词】 Modulation Intravenous GABAergic anesthetics are potent hypnotics but are rather ineffective in depressing movements。 We hypothesized that the efficacy of these anesthetics in produ...
09-08-25摘要:【关键词】 Signaling Many studies have suggested a role for the hepatocyte growth factor (HGF)/c-Met pathway in tumorigenesis。 Some actions of HGF are believed to be mediated by cyclooxygenase...
09-08-25摘要:【关键词】 Phosphorylation The recent biochemical demonstration of the association of the µ。-opioid receptor (MOR) with Gs that increases after long-term morphine treatment (Mol Brain Res...
09-08-25摘要:【关键词】 Nicotine Nicotine biotransformation affects the smoking habits of addicted individuals and therefore their health risk。 Nicotine is not carcinogenic by itself and might even have so...
09-08-25摘要:【关键词】 Perturbation We have recently characterized a series of 3-amino-2-phenyl-propene (APP) derivatives as reversible inhibitors for the bovine adrenal chromaffin granule vesicular monoam...
09-08-25摘要:【关键词】 Functional Human carbonyl reductase 1 (CBR1) metabolizes a variety of substrates, including the anticancer doxorubicin and the antipsychotic haloperidol。 The transcriptional regulat...
09-08-25摘要:【关键词】 Thiazolidinediones Considering the role of aberrant -catenin signaling in tumorigenesis, we investigated the mechanism by which the peroxisome proliferator-activated receptor (PPAR) ...
09-08-25摘要:【关键词】 Distinct Selective modulation of 7 nicotinic acetylcholine receptors (nAChRs) is thought to regulate processes impaired in schizophrenia, Alzheimer‘s disease, and other dementias。 ...
09-08-25摘要:【关键词】 Stromal The production of chemokine stromal cell-derived factor (SDF)-1 is significantly higher in synovial fluid of patients with osteoarthritis and rheumatoid arthritis。...
09-08-25摘要:【关键词】 Low-Dose We have examined the mechanisms by which the multinuclear platinum chemotherapeutic BBR3610 kills human colon cancer cells。 BBR3610 more efficiently killed HCT116, DLD1, SW...
09-08-25摘要:【关键词】 Interleukin-6 Carboxylesterases constitute a class of enzymes that play important roles in the hydrolytic metabolism of drugs and other xenobiotics。 In both primary hepatocytes and ...
09-08-25摘要:【关键词】 Up-Regulation The aim of the present study was to investigate whether KV3。 Up-Regulation of the Transcripts of KV3。42-Induced Apoptosis Is Accompanied by an Up-Regulation in KV3。
09-08-25摘要:【关键词】 Apoptotic Peroxisome proliferator-activated receptor (PPAR)- ligands have been shown to inhibit human lung cancers by inducing apoptosis and differentiation。 PPAR activation selecti...
09-08-25摘要:【关键词】 Exacerbation Protease-activated receptor 1 (PAR1) is a G-protein-coupled receptor activated by serine proteases and expressed in astrocytes, microglia, and specific neuronal populati...
09-08-25摘要:【关键词】 Phosphoinositide-Dependent The epidermal growth factor receptor (EGFR) is integral to basal-like and human epidermal growth factor receptor-2 (Her-2)-overexpressing breast cancers。 ...
09-08-25摘要:【关键词】 Tumor Cells Human telomeric DNA consists of tandem repeats of the sequence d(TTAGGG) with a 3‘ single-stranded extension (the G-overhang)。 Steroid FG, a funtumine derivative substi...
09-08-25摘要:【关键词】 Interactions Large-conductance Ca2+-activated K+ (BKCa) channels play an important role in the regulation of cell physiology in a wide variety of excitable and nonexcitable tissues。...
09-08-25摘要:【关键词】 Key Activation of group I metabotropic glutamate (mGlu) receptors recruits the endocannabinoid system to produce both short- and long-term changes in synaptic strength in many region...
09-08-25摘要:【关键词】 Human UDP-glucuronosyltransferases (UGTs) play important roles in the metabolism, detoxification,and clearance of many different xenobiotics, including drugs and endogenous compounds...
09-08-25摘要:【关键词】 Pregnane X The pregnane X receptor (PXR) is an important transcriptional regulator of the expression of xenobiotic metabolism and transporter genes。 Human PXR was expressed as a ful...
09-08-25摘要:【关键词】 Substrate The closely related G protein-coupled receptor kinases GRK2 and GRK3 are both expressed in cardiac myocytes。 Although GRK2 has been extensively investigated in terms of re...
09-08-25摘要:【关键词】 Structural Spirolactones are potent antagonists of the mineralocorticoid receptor (MR), a ligand-induced transcription factor belonging to the nuclear receptor superfamily。 Spirolac...
09-08-25摘要:【关键词】 Discovery The human pregnane X receptor (hPXR) is a nuclear receptor that regulates the expression of phase I and II drug-metabolizing enzymes as well as that of drug transporters。 ...
09-08-25摘要:【关键词】 Philinopside E Vascular endothelial growth factor (VEGF) signaling pathway is essential for tumor angiogenesis and has long been recognized as a promising target for cancer therapy。...
09-08-25摘要:【关键词】 Riboflavin 2-fold higher riboflavin association at the cell surface。 Endocytosis is a cellular absorption mechanism that serves as a major route for nutrient and macromolecule entry ...
09-08-25摘要:【关键词】 Impact -L-Dioxolane-cytidine (L-OddC, Troxacitabine, BCH-4556), a novel L-configuration deoxycytidine analog, is under clinical trials for treating cancer。 Phosphoglycerate kinase (...
09-08-25摘要:【关键词】 Molecular The calmodulin (CaM)-dependent adenylyl cyclase (AC) toxin from Bordetella pertussis (CyaA) substantially contributes to the pathogenesis of whooping cough。 Thus, potent a...
09-08-25摘要:【关键词】 Transcription Two vital enzymes of the CYP3A subfamily, CYP3A4 and CYP3A5, are differentially expressed in the human lung。 Binding reaction mixtures were preincubated at room temper...
09-08-25摘要:【关键词】 Localization In the present study, we have used wild-type and palmitoylation-deficient mouse 5-hydroxytryptamine1A receptor (5-HT1A) receptors fused to the yellow fluorescent protein...
09-08-25摘要:4 and its ancillary subunit MiRP2 in -amyloid (A) peptide-mediated neuronal death。 The MiRP2-Kv3。is now argued to be a molecular correlate of the transient outward potassium current up-regulated ...
09-08-25摘要: Andreola F, Fernandez-Salguero PM, Chiantore MV, Petkovich MP, Gonzalez FJ, and De Luca LM (1997) Aryl hydrocarbon receptor knockout mice (AHR–/–) exhibit liver retinoid ac...
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