摘要：【关键词】 Activation Oxidative stress, causing necrotic and apoptotic cell death, is associated with bile acid toxicity。 Using liver (HepG2, Hepa1c1c7, and primary human hepatocytes) and inte...

摘要：【关键词】 Ligand-Directed This study examines signaling pathways activated by the mouse 3-adrenoceptor (AR) expressed in Chinese hamster ovary cells at high (CHO3H) or low (CHO3L) levels。 Fun...

摘要：【关键词】 Evidence The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor responsible for mediating the cellular response to the toxic compound 2,3,7,8,-tetrachlorodibe...

摘要：【关键词】 Disruption The biological effects of many environmental toxins are mediated by genes containing Per-Arnt-Sim (PAS) domains, the aryl hydrocarbon receptor (AhR), and AhR nuclear trans...

摘要：【关键词】 Inhibition The Na+/dicarboxylate cotransporter NaDC1 absorbs citric acid cycle intermediates from the lumen of the small intestine and kidney proximal tubule。 No effective inhibitor...

摘要：【关键词】 Geranylgeranylacetone Geranylgeranylacetone (GGA), an antiulcer agent, has the ability to induce 70-kDa heat shock protein (HSP70) in various cell types and to protect cells from apo...

摘要：【关键词】 Neurosteroids Neurosteroids are endogenous neuromodulators that bind and allosterically regulate GABAA receptors。 Residues were recently identified in the first transmembrane domain...

摘要：【关键词】 Association CXCR4, the primary receptor for CXCL12, plays a critical role in the development of hematopoietic, vascular, central nervous, and immune systems by mediating directional ...

摘要：【关键词】 Role Voltage-gated potassium (KV) channels play an essential role in regulating pulmonary artery function, and they underpin the phenomenon of hypoxic pulmonary vasoconstriction。 Pu...

摘要：【关键词】 Involvement The endocannabinoid 2-arachidonoylglycerol (2-AG) enhances cell migration through the CB2 cannabinoid receptor。 In this study, using an immunoprecipitation and mass spec...

摘要：【关键词】 Polymorphic CYP2C9 catalyzes the demethylation of the biphasic kinetics substrate (S)-naproxen, and the CYP2C9*2 (R144C) and CYP2C9*3 (I359L) variants are associated with lower rates...

摘要：【关键词】 Pharmacological Despite its expression in different cell types, transient receptor potential V2 (TRPV2) is still the most cryptic members of the TRPV channel family。 2-Aminoethoxydi...

摘要：【关键词】 Inhibition 15-Deoxy-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenonic prostaglandin endowed with powerful anti-inflammatory activities, as shown in animal models of inflammatory...

摘要：【关键词】 Peroxisomal Peroxisome proliferator-activated receptor- (PPAR-) is a transcription factor and has been reported to inhibit cisplatin-mediated proximal tubule cell death。[Abstract/Fr...

摘要：【关键词】 Enhancing Previous studies have shown that a compound purified from the spider Parawixia bistriata venom stimulates the activity of glial glutamate transporters and can protect retin...

摘要：【关键词】 Mammalian Among scorpion - and -toxins that modify the activation and inactivation of voltage-gated sodium channels (Navs), depressant -toxins have traditionally been classified as a...

摘要：【关键词】 G Interferes Presynaptic inhibitory G protein-coupled receptors (GPCRs) can decrease neurotransmission by inducing interaction of G with the soluble N-ethylmaleimide-sensitive factor...

摘要：【关键词】 Rational Despite the emerging importance of human P450 2B6 in xenobiotic metabolism, thorough biochemical and biophysical characterization has been impeded as a result of low express...

摘要：Radioligand Binding Assays。 Binding assays at wild-type receptors used the high-expressing cell line (Hh2Ahi。43(239)A Mutation Detrimentally Affected the Binding and Activity of Tryptamines and P...

摘要：【关键词】 Dimerization The ubiquitously expressed nitric oxide (NO) receptor soluble guanylate cyclase (sGC) plays a key role in signal transduction。 Dimerization of the /-subunits has been p...

摘要：【关键词】 Evaluation We previously established a panel of human cancer cell lines, JFCR39, coupled to an anticancer drug activity database。 this panel is comparable with the NCI60 panel devel...

摘要：【关键词】 Regulation There is accumulating evidence that G protein-coupled receptor signaling is regulated by localization in lipid raft microdomains。 Receptors were immunoprecipitated from t...

摘要：【关键词】 Capacitative Thiazolidinediones (TZDs) are synthetic ligands for the peroxisome proliferator-activated receptor (PPAR) but also elicit PPAR-independent effects, most notably activati...

摘要：Among the 2000-compound National Cancer Institute Diversity set, we identified 8-benzyl-4-oxo-8-azabicyclo[3。1]oct-2-ene-6,7-dicarboxylic acid (SD-1008) as a micromolar inhibitor of interleukin-6 ...

摘要：【关键词】 Purinergic 2X1 ATP is an important endogenous mediator in the cardiovascular system。 Purinergic control of vascular tone is complex, because ATP released in response to vascular ins...

摘要：We hypothesized that reduced PAK activity was involved in the effects of 2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a previously character...

摘要：【关键词】 Identification We have identified two new histone deacetylase (HDAC) inhibitors (9 and 24) capable of inducing the expression of -globin and/or -globin promoter-driven reporter genes...

摘要：【关键词】 Regulation Regulation of the cysteine transporter known as excitatory amino acid carrier-1 (EAAC1) for intracellular glutathione (GSH) content was investigated using human embryonic ...

摘要：【关键词】 Pharmacology Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system。 After release from glutamatergic nerve terminals, glial and neuronal glutama...

摘要：【关键词】 Ligand-Directed In contrast to earlier concepts, it seems that distinct ligands acting on the same receptor may elicit qualitative different response patterns, a phenomenon given man...