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| 药物名称 | 促卵泡素α |
| 药物别名 | 促卵泡素α |
| 英文名称 | Follitropin alfa |
| 说 明 | |
| 功用作用 | Induction of ovulation and pregnancy in anovulatory infertile clients where cause of infertility is functional. To stimulate development of multiple follicles in ovulatory clients undergoing in-vitro fertilization. |
| 用法用量 | Follitropin Alfa SC only Ovulation induction. Initial, first cycle: 75 IU/day. An incremental adjustment up to 37.5 IU may be considered after 14 days; further increases can be made, if needed, every 7 days. To complete follicular development and effect ovulation in absence of an endogenous LH surge, give 5,000 units of HCG 1 day after last dose of follitropin alfa. Withold HCG if serum estradiol is greater than 2,000 pg/mL. Base initial dose in subsequent cycles on response in the preceding cycle. Doses greater than 300 IU/day are not recommended routinely. As in initial cycle, HCG at a dose of 5,000 is given 1 day after last dose of follitropin alfa. Follicle stimulation. Initiate on day 2 or 3 of the follicular phase at a dose of 150 IU/day, until sufficient follicular development is achieved. Usually, therapy does not exceed 10 days. In those undergoing in vitro fertilization whose endogenous gonadotropin levels are suppressed, initiate follitropin alfa at a dose of 225 IU/day. Consider dosage adjustments after 5 days based on client response; adjust subsequent dosage every 3 to 4 days and by less than 75 to 150 IU additional drug at each adjustment, not to exceed 450 IU/day. Once follicular development is achieved, give HCG, 5,000-10,000 units, to cause final follicular maturation in preparation for oocyte retrieval.Follitropin Beta SC, IM Ovulation induction. Use stepwise, gradually increasing dosage regimen. Initial: 75 IU/day for up to 14 days; increase by 37.5 IU at weekly intervals until follicular growth or serum estradiol levels indicate response. Maximum daily dose: 300 IU. Treat until ultrasonic visualization or serum estradiol levels indicate pre-ovulatory conditions greater than or equal to normal values. Then, give HCG 5,000-10,000 IU. Follicle stimulation. Initial: 150-225 IU for first 4 days of treatment. Dose may be adjusted based on ovarian response. Daily maintenance doses from 75-300 IU (however, doses from 375-600 IU have been used) for 6 to 12 days are usually sufficient. Maximum daily dose: 600 IU. When sufficient number of follicles of adequate size are present, induce final maturation by giving HCG, 5,000-10,000 IU. Oocyte retrieval is undertaken 34-36 hr later. |
| 注意事项 | Pregnancy Category: X
Contraindications: Use in primary ovarian failure; uncontrolled thyroid or adrenal dysfunction; in presence of any cause of infertility other than anovulation; tumor of ovary, breast, uterus, hypothalamus, or pituitary gland; abnormal vaginal bleeding of undetermined origin; ovarian cysts or enlargement not due to polycystic ovary syndrome; pregnancy; use in children; hypersensitivity to products. Special Concerns: Use with caution during lactation. |