角膜移植术后应用环孢霉素滴眼液的临床观察

    角膜移植术后应用环孢霉素滴眼液的临床观察 (pdf)

    ［摘要］  目的  对比研究穿透性角膜移植术不同术后处理方法及其术后排斥反应的发生率。方法  2组（48例）行穿透性角膜移植术角膜病患者，一组术后单独使用0.1%地塞米松滴眼，另一组采用环孢霉素A（1%CsA）和0.1%地塞米松（0.1%DXM）联合滴眼，对比2组术后排斥反应的发生率。结果  采用1%CsA联合0.1%DXM，术后治疗组排斥反应发生率明显低于单纯使用地塞米松组（P<0.05)。结论  术后采用CsA联合DXM治疗，可有效降低角膜移植术后的排斥反应发生率。

　［关键词］  环孢霉素A；穿透性角膜移植术；排斥反应

    Clinical studies on using cyclosporin A after penetrating keratoplast

    PAN Xun,FENG Jian-guo,ZHOU Min.Department of Ophthamology,Changzhou First Peoples Hospital,Changzhou 213003,China

    ［Abstract］  Objective  To evaluate the efficacy of 0.1% dexamethasone or 1%CsA combined with 0.1% dexamethasone in preventing and treating immune rejection after penetrating keratoplasty(PKP).Methods  Forty-eight PKP patients were divided into 2 groups,one was treated with 0.1% dexamethasone postoperative,the other was treated with 1% CsA and dexamethasone.The immune rejection rate was reviewed.Results  There was a statistical difference in the 2 groups in the postoperative immune rejection which occurred in 2 of 24 eyes treated with 1% CsA and dexamethasone,6 of 24 treated with 0.1% dexamethasone.Conclusion  The efficacy of CsA combined with dexamethasone topically is better than that of dexamethasone alone in preventing rejection episodes.

    ［Key words］  cyclosporin A;penetrating keratoplasty;rejection

    穿透性角膜移植术（penetrating keratoplasty,PKP)是角膜病盲患者复明的一种重要手术方法。随着显微手术技术的提高，手术因素对角膜移植术后效果的影响逐渐减少，角膜移植术的成功率有了很大提高，但术后排斥反应仍是导致移植失败的主要原因。近年来对角膜移植排斥反应的基础及临床研究取得了较大的进展，但确切的病理机制以及临床方面的许多问题仍未得到解决。进一步探讨角膜移植术后排斥反应的发生率，